Mujmmail Ahmed
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View article: JAK1/2 Inhibition Delays Cachexia and Improves Survival through Increased Food Intake
JAK1/2 Inhibition Delays Cachexia and Improves Survival through Increased Food Intake Open
Lung cancer is the leading cause of cancer-related death and is frequently accompanied by reduced food intake and cachexia, a debilitating syndrome characterized by weight loss and skeletal muscle wasting. We sought to identify contributor…
View article: Sustained Glucose Turnover Flux Distinguishes Cancer Cachexia from Nutrient Limitation
Sustained Glucose Turnover Flux Distinguishes Cancer Cachexia from Nutrient Limitation Open
Cancer cachexia is an involuntary weight loss condition characterized by systemic metabolic disorder. A comprehensive flux characterization of this condition however is lacking. Here, we systematically isotope traced eight major circulatin…
View article: Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer
Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer Open
Aim To investigate systemic regulators of the cancer‐associated cachexia syndrome (CACS) in a pre‐clinical model for lung cancer with the goal to identify therapeutic targets for tissue wasting. Methods Using the Kras/Lkb1 (KL) mouse model…
View article: TIMP1 is an early biomarker for detection and prognosis of lung cancer
TIMP1 is an early biomarker for detection and prognosis of lung cancer Open
Background Lung cancer remains the major cause of cancer‐related deaths worldwide. Early stages of lung cancer are characterized by long asymptomatic periods that are ineffectively identified with the current screening programs. This defic…
View article: The proteasome regulates body weight and systemic nutrient metabolism during fasting
The proteasome regulates body weight and systemic nutrient metabolism during fasting Open
Bortezomib treatment prevents tissue and body weight loss during fasting. The loss of proteasome activity with bortezomib exacerbates fasting-induced ketogenesis. During fasting, bortezomib increases AMPK and PI3K/AKT signaling in the live…
View article: Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer
Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer Open
The cancer associated cachexia syndrome (CACS) is a systemic metabolic disorder resulting in loss of body weight due to skeletal muscle and adipose tissues atrophy. CACS is particularly prominent in lung cancer patients, where it contribut…
View article: Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer
Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer Open