Mukesch Shah
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View article: EXTH-144. Multifunctional chimeric antigen receptor immune cell communities demonstrate promising preclinical safety and efficacy against glioblastoma
EXTH-144. Multifunctional chimeric antigen receptor immune cell communities demonstrate promising preclinical safety and efficacy against glioblastoma Open
There is an unmet medical need for more effective therapies against glioblastoma. Cellular immunotherapies with engineered immune cells expressing synthetic chimeric antigen receptors (CAR) to recognize and attack cancer cells have great t…
View article: International survey-based assessment of the reliability, validity, and interpretability of the TDN grade for neurosurgical adverse events
International survey-based assessment of the reliability, validity, and interpretability of the TDN grade for neurosurgical adverse events Open
Neurosurgical adverse events (AE) are frequent and may have dramatic consequences on quality of life. The lack of a standardized classification of their severity hinders evaluation and improvement of the safety of procedures. The Therapy-D…
View article: Human brain slice cultures: translational applications and ethical considerations
Human brain slice cultures: translational applications and ethical considerations Open
Human organotypic brain slice cultures have emerged as a pivotal tool to study the complexities of the human brain. Human organotypic brain slice cultures preserve the structural integrity, cellular diversity, and vascular networks of livi…
View article: P13.18.A MENINGIOMAP: A SINGLE-CELL ATLAS OF MENINGIOMA ECOSYSTEMS AND MICROENVIRONMENTAL NETWORKS
P13.18.A MENINGIOMAP: A SINGLE-CELL ATLAS OF MENINGIOMA ECOSYSTEMS AND MICROENVIRONMENTAL NETWORKS Open
BACKGROUND Meningiomas are the most common primary intracranial tumors, yet their cellular diversity, tumor-stroma interactions, and the relationship between neoplastic and normal meningeal cells remain incompletely understood. While recen…
View article: P08.14.B MULTIFUNCTIONAL CHIMERIC ANTIGEN RECEPTOR IMMUNE CELL COMMUNITIES DEMONSTRATE PROMISING PRECLINICAL SAFETY AND EFFICACY AGAINST GLIOBLASTOMA
P08.14.B MULTIFUNCTIONAL CHIMERIC ANTIGEN RECEPTOR IMMUNE CELL COMMUNITIES DEMONSTRATE PROMISING PRECLINICAL SAFETY AND EFFICACY AGAINST GLIOBLASTOMA Open
BACKGROUND There is an unmet medical need for more effective therapies against glioblastoma. Cellular immunotherapies with engineered immune cells expressing synthetic chimeric antigen receptors (CAR) to recognize and attack cancer cells h…
View article: P07.13.A ENHANCING NEUROSURGICAL GUIDANCE IN GLIOBLASTOMA USING NITROGEN VACANT (NV) DIAMOND QUANTUM SENSING
P07.13.A ENHANCING NEUROSURGICAL GUIDANCE IN GLIOBLASTOMA USING NITROGEN VACANT (NV) DIAMOND QUANTUM SENSING Open
BACKGROUND Accurate intraoperative delineation of tumor from eloquent brain is critical for safe and efficient glioblastoma resection. Conventional neuro-navigation offers anatomical guidance but lacks real-time functional feedback and is …
View article: Long‐term outcomes of stereotactic radiofrequency ablation in hypothalamic hamartomas: A single‐center experience
Long‐term outcomes of stereotactic radiofrequency ablation in hypothalamic hamartomas: A single‐center experience Open
Objective Hypothalamic hamartomas (HHs) lead to refractory epilepsy, and minimally invasive surgical approaches are standard of care for affected patients. Stereotactic radiofrequency thermocoagulation (SRT) is one of the treatment methods…
View article: P13.17.B HUMAN MENINGIOMA TUMOR MODELS REVEAL GRADE-SPECIFIC MICROENVIRONMENTAL INTERACTIONS
P13.17.B HUMAN MENINGIOMA TUMOR MODELS REVEAL GRADE-SPECIFIC MICROENVIRONMENTAL INTERACTIONS Open
BACKGROUND Meningiomas represent the most common primary intracranial tumors, accounting for approximately one-third of adult CNS tumors. Despite their frequency, model systems that accurately replicate the complex tumor-microenvironment i…
View article: P02.20.A IRON-DRIVEN MESENCHYMAL TRANSITION ENHANCES INVASION IN GLIOBLASTOMA
P02.20.A IRON-DRIVEN MESENCHYMAL TRANSITION ENHANCES INVASION IN GLIOBLASTOMA Open
BACKGROUND Iron metabolism is essential for tumor proliferation and survival, yet its dysregulation can drive mutagenesis and tumor evolution. Glioblastoma (GBM) stem-like cells tolerate high reactive oxygen species (ROS) levels and exploi…
View article: Contemporary Endovascular Techniques for Cerebral Aneurysms: Germany-wide In-hospital Outcomes vs. Coiling (2013–2022)
Contemporary Endovascular Techniques for Cerebral Aneurysms: Germany-wide In-hospital Outcomes vs. Coiling (2013–2022) Open
Background Clinical and administrative studies suggest better functional outcomes after endovascular treatment (EVT) of intracranial aneurysms (IAs) compared to neurosurgical clipping (NSC). However, it remains unclear whether this applies…
View article: B-waves in noninvasive capacitance signal correlate with B-waves in ICP
B-waves in noninvasive capacitance signal correlate with B-waves in ICP Open
View article: Autologous platelet-rich fibrin as an alternative epidural patch for persistent post-dural puncture headache: A single-center observational study
Autologous platelet-rich fibrin as an alternative epidural patch for persistent post-dural puncture headache: A single-center observational study Open
Objectives Epidural blood patch (EBP) is the current standard of care for postdural puncture headache (PDPH). However, when EBP fails to provide relief, patients may experience discomfort and functional impairments. This study reports the …
View article: Plain Language Summary Publication: Mild cognitive impairment in spontaneous intracranial hypotension and its rapid reversal by repair of a spinal cerebrospinal fluid leak
Plain Language Summary Publication: Mild cognitive impairment in spontaneous intracranial hypotension and its rapid reversal by repair of a spinal cerebrospinal fluid leak Open
View article: Twist-Drill Craniostomy With Pressure-Controlled Fibrinolytic Irrigation Therapy for the Evacuation of Acute Traumatic Subdural Hematoma in Patients Not Requiring Immediate Craniotomy
Twist-Drill Craniostomy With Pressure-Controlled Fibrinolytic Irrigation Therapy for the Evacuation of Acute Traumatic Subdural Hematoma in Patients Not Requiring Immediate Craniotomy Open
BACKGROUND AND OBJECTIVES: Acute subdural hematoma (aSDH) ranks among the most prevalent conditions in neurosurgery. Depending on the hematoma and neurological condition, management is surgical or conservative. Open craniotomy is the mains…
View article: Midterm results of the LEADR trial confirm ongoing safety, efficacy, and reliability of the novel, small-diameter OmniaSecure defibrillation lead
Midterm results of the LEADR trial confirm ongoing safety, efficacy, and reliability of the novel, small-diameter OmniaSecure defibrillation lead Open
Introduction Defibrillation leads remain the weak point of implantable cardioverter-defibrillators due to potential lead failure that may result in adverse patient outcomes. Thus, modern defibrillation leads that are safe, efficacious, and…
View article: Sensing and detection performance of the novel, small-diameter omniasecure defibrillation lead: leadr trial analysis
Sensing and detection performance of the novel, small-diameter omniasecure defibrillation lead: leadr trial analysis Open
Introduction The Lead EvaluAtion for Defibrillation and Reliability (LEADR) trial evaluated the small-diameter (4.7Fr), integrated bipolar OmniaSecure defibrillation lead. The trial exceeded primary safety and efficacy endpoint thresholds,…
View article: Platelet rich fibrin and commercial sealants for dural closure in neurosurgery: An in vitro study
Platelet rich fibrin and commercial sealants for dural closure in neurosurgery: An in vitro study Open
Background Watertight closure of the dura mater is essential after neurosurgical interventions to avoid complications such meningitis, intracranial hypotension and surgical site infections. In addition to conventional suturing techniques, …
View article: Twist-drill craniostomy with pressure-controlled fibrinolytic irrigation therapy reduces recurrence of chronic subdural hematomas: initial experience in 16 cases
Twist-drill craniostomy with pressure-controlled fibrinolytic irrigation therapy reduces recurrence of chronic subdural hematomas: initial experience in 16 cases Open
Preliminary data on TDC-FIT suggests improved reoperation rate and membranous hematoma resolution with comparable safety profiles to conventional TDC. Further prospective studies are needed to validate these findings in larger cohorts.
View article: B-waves in noninvasive capacitance signal correlate with B-waves in ICP
B-waves in noninvasive capacitance signal correlate with B-waves in ICP Open
View article: Twist-drill craniostomy with pressure-controlled fibrinolytic irrigation therapy for the evacuation of bilateral acute traumatic subdural hematoma: illustrative case
Twist-drill craniostomy with pressure-controlled fibrinolytic irrigation therapy for the evacuation of bilateral acute traumatic subdural hematoma: illustrative case Open
BACKGROUND Bilateral acute subdural hematomas (aSDHs) present a significant challenge for neurosurgeons, particularly due to the risk of contralateral hematoma enlargement following unilateral evacuation and subsequent volume shifts. This …
View article: A simple CT score predicts early neurological disability and survival in supratentorial intracerebral hemorrhage - The intracerebral mass and brain edema score (IMBES)
A simple CT score predicts early neurological disability and survival in supratentorial intracerebral hemorrhage - The intracerebral mass and brain edema score (IMBES) Open
We observed a decreased neurological recovery and an increased mortality for patients with high IMBES during acute care and at early follow-up, indicating that IMBES had the strongest association in all regression analysis. We conclude tha…
View article: Twist-drill craniostomy with pressure controlled fibrinolytic irrigation reduces recurrence of chronic subdural hematoma
Twist-drill craniostomy with pressure controlled fibrinolytic irrigation reduces recurrence of chronic subdural hematoma Open
View article: Twist-drill craniostomy with pressure-controlled fibrinolytic irrigation: A safer alternative to craniotomy in patients with acute subdural hematomas that do not require immediate evacuation?
Twist-drill craniostomy with pressure-controlled fibrinolytic irrigation: A safer alternative to craniotomy in patients with acute subdural hematomas that do not require immediate evacuation? Open
View article: Feasibility and safety of cortical access point biopsy during hydrocephalus shunt surgery
Feasibility and safety of cortical access point biopsy during hydrocephalus shunt surgery Open
View article: Cerebral amyloid angiopathy in spontaneous intracerebral hemorrhage – radiology and immunohistochemistry in a consecutive surgical series
Cerebral amyloid angiopathy in spontaneous intracerebral hemorrhage – radiology and immunohistochemistry in a consecutive surgical series Open
View article: Dysregulation of Myelination in Focal Cortical Dysplasia Type <scp>II</scp> of the Human Frontal Lobe
Dysregulation of Myelination in Focal Cortical Dysplasia Type <span>II</span> of the Human Frontal Lobe Open
Focal cortical dysplasias (FCDs) are local malformations of the human neocortex and a leading cause of intractable epilepsy. FCDs are classified into different subtypes including FCD IIa and IIb, characterized by a blurred gray‐white matte…
View article: Mild cognitive impairment in spontaneous intracranial hypotension and its rapid reversal by repair of a spinal cerebrospinal fluid leak
Mild cognitive impairment in spontaneous intracranial hypotension and its rapid reversal by repair of a spinal cerebrospinal fluid leak Open
Background Patients with spontaneous intracranial hypotension (SIH) report difficulties in concentration and memory. To objectify these deficits, we implemented standard cognitive tests into our routine SIH workup. Method Retrospective, si…
View article: Platelet rich fibrin three-layer reconstruction of the sellar floor after endoscopic endonasal transsphenoidal approach: technical note and initial experience
Platelet rich fibrin three-layer reconstruction of the sellar floor after endoscopic endonasal transsphenoidal approach: technical note and initial experience Open
Background Cerebrospinal fluid (CSF) leakage frequently complicates endoscopic endonasal transsphenoidal pituitary resections, despite the use of lumbar drains, nasoseptal flaps, or commercial dura sealants. Managing this complication ofte…
View article: Safety, Sequelae, and Efficacy of Nerve Root Clipping in Patients With Spontaneous Spinal Cerebrospinal Fluid Leaks
Safety, Sequelae, and Efficacy of Nerve Root Clipping in Patients With Spontaneous Spinal Cerebrospinal Fluid Leaks Open
BACKGROUND AND OBJECTIVES: Spinal cerebrospinal fluid (CSF) leaks may cause a myriad of clinical symptoms, the most common being orthostatic headache. Lateral leaks (Type II) and direct CSF-venous fistulas (Type III) are a subgroup of spin…
View article: More than a headache—somatic and mental symptom burden in spontaneous intracranial hypotension before and after surgical treatment
More than a headache—somatic and mental symptom burden in spontaneous intracranial hypotension before and after surgical treatment Open
Introduction Patients with spontaneous intracranial hypotension (SIH) frequently present with several symptoms and impaired mental health. This study systematically investigates the somatic and mental symptom burden of SIH and the effect o…