Explanipedia

THE EVOLVING ROLE OF PHYTOCHEMICALS IN CANCER THERAPY: MECHANISTIC INSIGHTS AND EMERGING TECHNOLOGIES Open

Mukesh C. Sharma, Abhijeet Singh, Ritika Rana, Aman Kumar, M Chauhan · 2025

Cancer remains one of the leading causes of global morbidity and mortality, necessitating the search for novel, effective, and safer therapeutic strategies. Phytochemicals—bioactive compounds derived from medicinal plants—have demonstrated…

The Intersection of Bioethics, Law, and Surgical Procedures Open

Nitin Nangare, Nitin Nangare, Palak Otwani, M.B. Bagwan, Rashmi S. Goswami , et al. · 2025

Bioethics, law, and medical processes all come together in this important area of study to look at tough moral problems, changing laws, and higher standards in the field of surgery. Robots, processes helped by artificial intelligence, and …

Soil: forensic interpretation some cases study Open

Mukesh C. Sharma, K. C. Bansal, S.S. Daga · 2024

While investigating a crime scene related to murder, hit-and-run accidents, road accident analysis, vehicles collisions, rapes and burglaries, forensic soil examination is used for linking the suspect or an object to the crime scene. Compa…

HEART HOLE- AN ABNORMAL BIRTH DEFECT Open

Amit Sharma, Surbhi Sharma, Mukesh C. Sharma · 2023

Heart hole defect is very common among newborns, it is due to structural abnormalities of the heart. Congenital means present from birth and affects almost in 100 newly born. Some Congenital heart diseases are lethal if not treated and som…

Quantitative structure activity relationship studies of some quinoline derivatives of angiotensin II receptor inhibitors Open

Mukesh C. Sharma, Dharm Veer Kohli · 2023

The aim of this study is to develop 3D-QSAR models to validate the antihypertensive activity of quinoline derivatives and insight into the requirements for the improvement of activity for the designing of more potent analogues of new thera…

Pharmacophore and k nearest neighbor studies on pyridazinylmethyl glucoside congeners derivative as potential antidiabetic agents Open

Mukesh C. Sharma · 2023

The article describes the development of a robust models and the investigation of structure activity relationship of forty one pyridazinylmethylphenyl derivatives reported for novel c-aryl glucoside SGLT2 inhibitors.3D QSAR studies produce…

Exploring the molecular structural requirements of 3, 4, 5-trisubstituted triazoles and imidazotriazole analogues as angiotensin II receptor using molecular modeling approach Open

Mukesh C. Sharma · 2023

This work presents the development of a quantitative structure-activity relationship model to predict the antihypertensive activity of 3,4,5-trisubstituted 4H-1,2,4-triazoles and a related series of 3H-imidazo [1,2b] [1,2,4] triazoles deri…

Effect of supported sitting position during second stage of labor on its outcome in primigravidae: A quasi-experimental study Open

Jagriti Chauhan, Himanshu Vyas, Pratibha Singh, Mukesh C. Sharma, Deviga Thirunavukkarasu · 2023

A BSTRACT Background: The childbirth position has a significant influence on labor, maternal comfort, and neonatal outcome. In sitting position, there is a faster fetal descent with the effect of gravity. The information on this subject is…

32 Factorial Design of O/W Nanoemulsions of Cholecalciferol Using Box–Behnken Model for Plaque Psoriasis Open

Mukesh C. Sharma, Mukul Sharma · 2023

Aim: The aim of the study was to design O/W Nanoemulsion using Cholecalciferol in different ratios of surfactants with Box-Behnken design model using Design Expert version 12. Response surface methodology, Box-Behnken was most suited follo…

A Novel Approaches to Feverfew (<i>Tanacetum Prthenium</i>): A Review Open

Iqbal Danish, Tyagi L.K., Mukesh C. Sharma · 2023

Tanacetum Parthenium is a herbal medicinal plant which is known as feverfew. Asterace is the family of feverfew. It is traditionally applicable in the treatment of stomach aches, fever, arthritis, infertility, migraine, insect bites, menst…

Synthesis and biological evaluation of some substituted benzimidazole derivatives as antihypertensive activities Open

Mukesh C. Sharma, Dharm Veer Kohli · 2023

A new compound benzimidazole derivative was designed, synthesized and evaluated as a novel antihypertensive activity.A number of substituted benzimidazole were synthesized in good yields and the structures were corroborated on the basis of…

Antipsoriatic activity of imiquimod induced wistar model treated with cholecalciferol nanoemulsion with UV therapy Open

Mukul Sharma, Mukesh C. Sharma · 2023

Psoriasis is the most common autoimmune skin condition affecting around 2-3% of world population which in severe cases found associated with comorbidities like arthritis and heart condition, etc.To measure the severity of the illness based…

Synthesis and biological evaluation of some substituted pyrazolopyrimidines derivatives as potential a-glucosidase inhibitors Open

Mukesh C. Sharma · 2023

Present communication deals with the synthesis of a novel series of substituted ethyl 6-substituted (2phenyldiazenyl)-4,5-dihydro-7-methylpyrazolo[1,5-a]pyrimidine-5-carboxylate compounds were synthesized and evaluated for invitro a-glucos…

Houttuynia cordata Thumb. extract for the treatment of triple negative breast cancer Open

Neha Maheshwari, Mukesh C. Sharma · 2023

1. IntroductionBreast cancer with triple-negative status (TNBC), which affects two out of every 12000 women, is the most challenging form of the disease (Bianchini et al., 2022;Zagami and Carey, 2022).Various factors contribute to the diff…

Preformulation and synthesis of retinol acetate nanoemulsion for skin disorder Open

Mukul Sharma, Mukesh C. Sharma · 2023

The objective of this study is to perform preformulation and synthesis of nanoformulation of drug for skin disorder.Preformulation study helped in qualitative estimation of drug and excipients used.The formula optimized by Box Behnken desi…

Recent Advances in Polymer-Based Nanomaterials for Non-Invasive Photothermal Therapy of Arthritis Open

Muktika Tekade, Prashant Pingale, Rachna Gupta, Bhakti Pawar, Rakesh Kumar Tekade , et al. · 2023

To date, nanomaterials have been widely used for the treatment and diagnosis of rheumatoid arthritis. Amongst various nanomaterials, polymer-based nanomaterials are becoming increasingly popular in nanomedicine due to their functionalised …

Analysis of Soil in Crime Cases and Its Importance: Cases Study Open

Mukesh C. Sharma · 2023

Forensic Science & Addiction Research Analysis of Soil in Crime Cases and Its Importance: Cases Study Supriya Ghajbhye1, Shreya Sharma2 and Mukesh Sharma3* 1PG Student, Department of Forensic Science, Viveknanda Global University, Jaipur, …

A pilot study on review of GSR with a case study Open

Rajat Mishra, Anil Budania, Ruchika Chouhan, Mukesh C. Sharma · 2022

In all types of heinous crime cases like murder, homicides, assassinations, police encounter with criminal firearms are mostly involved which make important trace evidence as Gunshot residue (GSR), helps the investigating agency and forens…

Fifatrol, An Ayurvedic Formulation-A Prospective Multi-Center Observational Study On The Symptoms of Upper Respiratory Tract Infections Open

Santosh Kumar Verma, Abdul Haye, Shubham Saxena, Mohammad Junaid, Mukesh C. Sharma · 2021

Background: Upper respiratory tract infections (URTI) is a leading cause of economic burden as it remains among the top 3 diagnosed diseases globally with an estimated annual cost above $22 billion.Available medications to treat URTI and a…

Murder Mystery Solved with the Help of Forensic Investigation Open

Mukesh C. Sharma, Varsha Sharma · 2020

Crime scene reconstruction is the process of determining or eliminating the events that occurred at the crime scene by analysis of physical evidences.In one case, a lady left the house receiving a call on her cell phone.Since she did not r…

Graphene-based hybrid nanoparticle of doxorubicin for cancer chemotherapy Open

Nagaraja Sreeharsha, Rahul Maheshwari, Bandar E. Al‐Dhubiab, Muktika Tekade, Mukesh C. Sharma , et al. · 2019

This delivery tool offers a feasible and viable method to deliver DOX photo-thermally in the treatment of prostate cancer.

Synthesis and Evaluation of Aldehyde Derivatives of Sulfonyl Chloride Quinoxaline Open

Rakesh Goyal, Mukesh C. Sharma, Dharmendra Ahuja, Anurekha Jain · 2019

In pyrazine mesomeric interaction between the protonated & neutral nitrogen atoms probably destabilizes the cation.N, N’-diprotonation is very easier for pyrazine Synthesis of 2, 3-diphenylquinoxaline by phenylene-diamine in 16 ml of recti…

Anisotropic thermoelectric properties of EuCd$_{2}$As$_{2}$ : An Ab-initio study Open

Jyoti Krishna, Mukesh C. Sharma, T. Maitra · 2019

In search of better thermoelectric materials, we have systematically investigated the thermoelectric properties of a 122 Zintl phase compound EuCd$_{2}$As$_{2}$ using \textit{ab-initio} density functional theory and semi-classical Boltzman…

Synthesis and Evaluation of Phenol Derivatives of Sulfonyl Chloride Quinoxaline Open

Rakesh Goyal, Mukesh C. Sharma, Dharmendra Ahuja, Anurekha Jain · 2019

The objective of the present study was to synthesize some new 7-sulfonate of 2, 3- Diphenyl quinoxaline which are more potential as antibacterial than parent quinoxalines. The present study was synthesis of derivatives of sulfonyl chloride…

Big Data Analysis of Traditional Knowledge-based Ayurveda Medicine Open

Harpreet Singh, Sapna Bhargava, Sailesh Ganeshan, Ravneet Kaur, Tavpritesh Sethi , et al. · 2018

Introduction:. Modern medicine has embraced data-driven understanding of health, principally through electronic medical records. However, Ayurveda, which is the dominant traditional medicine system in India, much of it is still practiced w…

In silico screening for identification of pyrrolidine derivatives dipeptidyl peptidase-IV inhibitors using COMFA, CoMSIA, HQSAR and docking studies Open

Mukesh C. Sharma, Sanmati Kumar Jain, Rajesh Sharma · 2017

Psycho sexual profile of perimenopausal and post-menopausal women visiting a tertiary care centre Open

Mukesh C. Sharma, Poonam Mani, Shashi Prateek, Lalita Yadav, Jasneet Dhingra · 2017

Background: The objective was to study the psychosexual profile of perimenopausal and postmenopausal females visiting a tertiary care centre.Methods: The present study was carried out in the Obstetrics and Gynecological Department of Subha…

Detection of Biofilms in <i>Candida</i> Species in a Resource Limited Setting Open

Mukesh C. Sharma, Dinesh Kumar, Sandeep Rana, Shobha Broor · 2017

The incidence of fungal infections has increased significantly. Of these, Candida species are major human fungal pathogens. Since biofilms have been considered as a virulence factor contributing to the Candida infection, a reliable method …

X-Ray Fluorescence Analysis: Useful For Forensic Examination Open

Mukesh C. Sharma · 2016

In the field of forensic science, it is very important to investigate of evidential samples obtained at various crime scenes.X-ray fluorescence (XRF) is used widely in forensic science.Its main strength is its non-destructive nature, thus …

2D QSAR studies of the inhibitory activity of a series of substituted purine derivatives against c-Src tyrosine kinase Open

Mukesh C. Sharma · 2015

A series of 34 substituted purine analogues derivatives were subjected to quantitative structure-activity relationship analyses as inhibitors of c-Src tyrosine kinase. Partial least squares regression was applied to derive QSAR models, whi…

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