Hasan Mukhtar
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View article: New Strategy for the Degradation of High-Concentration Sodium Alginate with Recombinant Enzyme 102C300C-Vgb and the Beneficial Effects of Its Degradation Products on the Gut Health of Stichopus japonicus
New Strategy for the Degradation of High-Concentration Sodium Alginate with Recombinant Enzyme 102C300C-Vgb and the Beneficial Effects of Its Degradation Products on the Gut Health of Stichopus japonicus Open
High viscosity of alginate means a relatively low substrate concentration, which limits the efficiency of hydrolysis, resulting in one of the main challenges for the large-scale production of alginate oligosaccharides (AOS). In this study,…
View article: The prevalence of dental caries among Schoolchildren in a sample of schools in Ajdabiya City; A cross-sectional study
The prevalence of dental caries among Schoolchildren in a sample of schools in Ajdabiya City; A cross-sectional study Open
Background: Dental caries is an infectious microbiological disease of the teeth that results in localized dissolution and destruction of the calcified dental tissues. It remains one of the most prevalent pathological conditions among child…
View article: Use and Outcomes of Vascular Access in Complicated Paediatric Appendicitis – A Multicentre Prospective Observational Study
Use and Outcomes of Vascular Access in Complicated Paediatric Appendicitis – A Multicentre Prospective Observational Study Open
AVAD insertion should be considered at appendicectomy in younger children with intra-operative findings of perforated appendicitis, appendix mass or widespread pus. Age, with a cut-off of 8 years, should be added to existing guidelines of …
View article: Metric Degree Polynomial and Eccentricity Sequence of Symmetric Hollow Coronoid Polycyclic Conjugated Hydrocarbons
Metric Degree Polynomial and Eccentricity Sequence of Symmetric Hollow Coronoid Polycyclic Conjugated Hydrocarbons Open
Polycyclic conjugated hydrocarbons (PCHs) with symmetric hollow coronoid structures represent a fundamental class of molecular graphs, exhibiting unique topological and electronic properties. This study systematically investigates the metr…
View article: Waist-to-height ratio and body roundness index as predictors of insulin resistance in Pakistani adults
Waist-to-height ratio and body roundness index as predictors of insulin resistance in Pakistani adults Open
Background: A major risk factor for metabolic syndrome and type 2 diabetes mellitus (T2DM), insulin resistance (IR) is especially common in South Asian populations. One of the main causes of IR, central adiposity, is not well represented b…
View article: PERCEPTIONS AND EXPERIENCES OF DOCTORS CONCERNING GENDER-BASED STEREOTYPES AND DISCRIMINATION IN THE WORKPLACE: A CROSS-SECTIONAL STUDY IN TERTIARY CARE HOSPITALS OF PESHAWAR
PERCEPTIONS AND EXPERIENCES OF DOCTORS CONCERNING GENDER-BASED STEREOTYPES AND DISCRIMINATION IN THE WORKPLACE: A CROSS-SECTIONAL STUDY IN TERTIARY CARE HOSPITALS OF PESHAWAR Open
Background: Gender-based discrimination can be explained as treating unfairly an individual based on their gender. It has become a major issue in our society despite the rising awareness regarding gender equality among the masses. Gender d…
View article: Preoperative anastomotic evaluation prior to ileostomy closure: A 5‐year UK survey, systematic review, and meta‐analysis
Preoperative anastomotic evaluation prior to ileostomy closure: A 5‐year UK survey, systematic review, and meta‐analysis Open
Aim To compare current UK surgical practice against evidence‐based anastomotic evaluation techniques prior to ileostomy closure. Methods An online survey was distributed to UK consultant colorectal surgeons with Association of Coloproctolo…
View article: Attitudes, Knowledge, and Practices Regarding Chronic Kidney Disease Among Patients
Attitudes, Knowledge, and Practices Regarding Chronic Kidney Disease Among Patients Open
Chronic kidney disease (CKD) poses a growing public health burden globally, particularly in low- and middle-income countries like Pakistan. Patient knowledge, attitudes, and practices (KAP) are key factors influencing disease management an…
View article: Correlation Between Self-Esteem, Locus of Control, And Quality of Life in Individuals Undergoing Drug Addiction Rehabilitation: A Cross-Sectional Study
Correlation Between Self-Esteem, Locus of Control, And Quality of Life in Individuals Undergoing Drug Addiction Rehabilitation: A Cross-Sectional Study Open
OBJECTIVES This study aimed to assess the levels of self-esteem, locus of control, and quality of life in patients attending drug addiction rehabilitation centers. It also sought to explore the relationships between self-esteem, locus of c…
View article: Investigation the Antioxidant Features and Therapeutic Potential of Onion Peel Husk on Elevated Liver Enzymes with Induced Liver Fibrosis in Male Albino Rats
Investigation the Antioxidant Features and Therapeutic Potential of Onion Peel Husk on Elevated Liver Enzymes with Induced Liver Fibrosis in Male Albino Rats Open
Liver inflammations and fibrosis can be due to liver injury. In liver fibrosis, inflammations which trigger myofibroblasts in the liver release extracellular matrix proteins that produce fibrous scar. There exist a number of plants which a…
View article: Assessment of Simplified Surveillance for Congenital Rubella Syndrome in Sudan, 2014–2017
Assessment of Simplified Surveillance for Congenital Rubella Syndrome in Sudan, 2014–2017 Open
Background/Objectives: Congenital rubella syndrome (CRS) is a constellation of serious multi-organ birth defects following rubella virus infection during early pregnancy. Countries in which rubella vaccination has not yet been introduced c…
View article: SP11.11 Getting It Right First Time (GIRFT): An Audit of General Surgical Documentation in a District General Hospital
SP11.11 Getting It Right First Time (GIRFT): An Audit of General Surgical Documentation in a District General Hospital Open
Aim Getting It Right the First Time (GIRFT) has released national guidance regarding operation documentation for common general surgical procedures, namely laparoscopic appendicectomy, laparotomy & laparoscopic bowel resection surgery, lap…
View article: Chitosan-Based Nanoformulated (–)-Epigallocatechin-3-Gallate (EGCG) Modulates Human Keratinocyte-Induced Responses and Alleviates Imiquimod-Induced Murine Psoriasiform Dermatitis [Erratum]
Chitosan-Based Nanoformulated (–)-Epigallocatechin-3-Gallate (EGCG) Modulates Human Keratinocyte-Induced Responses and Alleviates Imiquimod-Induced Murine Psoriasiform Dermatitis [Erratum] Open
[This corrects the article DOI: 10.2147/IJN.S165966.].
View article: Data from AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer
Data from AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer Open
Hyperactivated AKT kinase due to loss of its negative regulator PTEN influences many aspects of cancer biology, including chromatin. AKT primarily regulates acetyl-CoA production and phosphorylates many histone-modulating enzymes, resultin…
View article: Supplementary Figures 1-2 from Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells
Supplementary Figures 1-2 from Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells Open
Figure S1. Effect of fisetin and cabazitaxel, and their combination in-vitro.Figure S2. Effect of fisetin and cabazitaxel treatment of metastatic growth of PC-3M-luc-6 cell-derived tumors in mice.
View article: Data from Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells
Data from Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells Open
Although treatment of prostate cancer has improved over the past several years, taxanes, such as cabazitaxel, remain the only form of effective chemotherapy that improves survival in patients with metastatic castration–resistant prostate c…
View article: Supplementary Figures 1-2 from Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells
Supplementary Figures 1-2 from Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells Open
Figure S1. Effect of fisetin and cabazitaxel, and their combination in-vitro.Figure S2. Effect of fisetin and cabazitaxel treatment of metastatic growth of PC-3M-luc-6 cell-derived tumors in mice.
View article: Data from Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells
Data from Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells Open
Although treatment of prostate cancer has improved over the past several years, taxanes, such as cabazitaxel, remain the only form of effective chemotherapy that improves survival in patients with metastatic castration–resistant prostate c…
View article: Data from AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer
Data from AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer Open
Hyperactivated AKT kinase due to loss of its negative regulator PTEN influences many aspects of cancer biology, including chromatin. AKT primarily regulates acetyl-CoA production and phosphorylates many histone-modulating enzymes, resultin…
View article: Figure S1 from AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer
Figure S1 from AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer Open
Supplementary Figure S1: showing H&E staining of PTEN wild type (A) and knock out mice treated with vehicle (B) and perifosine (C).
View article: Figure S1 from AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer
Figure S1 from AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer Open
Supplementary Figure S1: showing H&E staining of PTEN wild type (A) and knock out mice treated with vehicle (B) and perifosine (C).
View article: Data from Targeted Knockdown of <i>Notch1</i> Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator
Data from Targeted Knockdown of <i>Notch1</i> Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator Open
Purpose:Notch, a type 1 transmembrane protein, plays a key role in the development of many tissues and organ types. Aberrant Notch signaling, found in a wide variety of human cancers, contributes to tumor development. …
View article: Supplementary Data from Targeted Knockdown of <i>Notch1</i> Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator
Supplementary Data from Targeted Knockdown of <i>Notch1</i> Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator Open
Supplementary Data from Targeted Knockdown of Notch1 Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator
View article: Data from Targeted Knockdown of <i>Notch1</i> Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator
Data from Targeted Knockdown of <i>Notch1</i> Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator Open
Purpose:Notch, a type 1 transmembrane protein, plays a key role in the development of many tissues and organ types. Aberrant Notch signaling, found in a wide variety of human cancers, contributes to tumor development. …
View article: Supplementary Data from Targeted Knockdown of <i>Notch1</i> Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator
Supplementary Data from Targeted Knockdown of <i>Notch1</i> Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator Open
Supplementary Data from Targeted Knockdown of Notch1 Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator
View article: Supplementary Figure 4 from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate
Supplementary Figure 4 from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate Open
Supplementary Figure 4 from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate
View article: Data from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate
Data from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate Open
Chemoprevention, especially through the use of naturally occurring phytochemicals capable of impeding the process of one or more steps of carcinogenesis process, is a promising approach for cancer management. Despite promising results in p…
View article: Supplementary Figure 3 from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate
Supplementary Figure 3 from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate Open
Supplementary Figure 3 from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate
View article: Supplementary Figure 2 from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate
Supplementary Figure 2 from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate Open
Supplementary Figure 2 from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate
View article: Supplementary Figure 2 from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate
Supplementary Figure 2 from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate Open
Supplementary Figure 2 from Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate