Mukul R. Jain
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View article: Peptide-Based Anti-PCSK9 Product for Long-Lasting Management of Hypercholesterolemia
Peptide-Based Anti-PCSK9 Product for Long-Lasting Management of Hypercholesterolemia Open
Background/Objectives: Hypercholesterolemia remains a major risk factor for cardiovascular disease and a leading cause of global mortality. Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes degradation of low-density lipoprote…
View article: Adaptive control strategies for button motor actuated insect scale flapping wing MAV mechanisms
Adaptive control strategies for button motor actuated insect scale flapping wing MAV mechanisms Open
The development of Flapping Wing Micro Aerial Vehicles (FWMAVs) has gained significant attention due to their potential for energy-efficient, lightweight, and highly maneuverable flight inspired by nature. This study presents innovative de…
View article: Clinical Trial Sites and Malaria Incidence Mismatch
Clinical Trial Sites and Malaria Incidence Mismatch Open
View article: Accelerating point defect photo-emission calculations with machine learning interatomic potentials
Accelerating point defect photo-emission calculations with machine learning interatomic potentials Open
We introduce a computational framework leveraging universal machine learning interatomic potentials (MLIPs) to dramatically accelerate the calculation of photoluminescence (PL) spectra of atomic or molecular emitters with ab initio accurac…
View article: HIF–Prolyl Hydroxylase Inhibitor Desidustat Increases Pyruvate Kinase Activity and Reduces Oxidative Stress in Red Blood Cells, Causes Erythrocytosis in Thalassaemic Mice, and Reduces Sickling in Sickle Cell Patient's Blood
HIF–Prolyl Hydroxylase Inhibitor Desidustat Increases Pyruvate Kinase Activity and Reduces Oxidative Stress in Red Blood Cells, Causes Erythrocytosis in Thalassaemic Mice, and Reduces Sickling in Sickle Cell Patient's Blood Open
Sickle cell anemia and beta‐thalassemia are the major hemoglobinopathies associated with anemia. Bone marrow transplants or blood transfusion are frequently employed as treatment for these diseases, and erythropoietin analogues are sometim…
View article: Age and Sex-Dependent Variations in Hematological, Biochemical, and Electrocardiographic Parameters in Beagle Dogs
Age and Sex-Dependent Variations in Hematological, Biochemical, and Electrocardiographic Parameters in Beagle Dogs Open
This study analyzed hematological, biochemical, and electrocardiographic parameters in 436 Beagle dogs (9-84 months old) to establish baseline reference indices by age and sex, and to evaluate the effects of these factors on physiological …
View article: Extraction of DNA fingerprinting from human hair in alcohol base after potentization
Extraction of DNA fingerprinting from human hair in alcohol base after potentization Open
View article: Empowering Pandemic Resilience: Simulation of Integrating IoT Innovation to Curtail Mortality
Empowering Pandemic Resilience: Simulation of Integrating IoT Innovation to Curtail Mortality Open
Historically Pandemic and Epidemic Prone (PEP) diseases rapidly inflame the respiratory tract and influence heart rate very badly, like how corona virus 2019 was transmitted by SARS-CoV-2. Thus, this article proposes a conceptual design th…
View article: Effects of intermittent fasting on body composition, clinical health markers and memory status in the adult population: a single-blind randomised controlled trial
Effects of intermittent fasting on body composition, clinical health markers and memory status in the adult population: a single-blind randomised controlled trial Open
View article: Comparative Evaluation of Survival Rate Gingival Health and Patient\'s Acceptance of Conventional Band and Loop and Prefabricated Band and Loop in Primary Teeth: An In Vivo Study
Comparative Evaluation of Survival Rate Gingival Health and Patient\'s Acceptance of Conventional Band and Loop and Prefabricated Band and Loop in Primary Teeth: An In Vivo Study Open
Dutta S, Gupta S, Tripathi P, et al. Comparative Evaluation of Survival Rate Gingival Health and Patient's Acceptance of Conventional Band and Loop and Prefabricated Band and Loop in Primary Teeth: An In Vivo Study. Int J Cli…
View article: Age-related changes in hematological and biochemical profiles of Wistar rats
Age-related changes in hematological and biochemical profiles of Wistar rats Open
View article: Comparative evaluation of clinical success of Stainless Steel and Bioflx crowns in primary molar – A 12 month split mouth prospective randomized clinical trial
Comparative evaluation of clinical success of Stainless Steel and Bioflx crowns in primary molar – A 12 month split mouth prospective randomized clinical trial Open
Purpose: The purpose of this clinical trial was to assess and compare the clinical outcomes of Bioflx crowns (BFCs) with stainless steel crowns (SSCs) in primary molars (PMs). Materials and Methods: This prospective split-mouth randomized …
View article: A Novel Selective NLRP3 Inhibitor Shows Disease Modifying Potential in Animal Models of Parkinson's Disease
A Novel Selective NLRP3 Inhibitor Shows Disease Modifying Potential in Animal Models of Parkinson's Disease Open
View article: Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet
Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet Open
View article: A Peculiar Concurrent Presentation of Spinal Tuberculosis In A Diagnosed Case of Neurofibromatosis Type 1 – An Atypical Case Report
A Peculiar Concurrent Presentation of Spinal Tuberculosis In A Diagnosed Case of Neurofibromatosis Type 1 – An Atypical Case Report Open
Spinal tuberculosis is a prevalent ailment observed in the Asian demographic, which can result in neurodeficit if not addressed during the initial phases. Neurofibromatosis is a hereditary disorder that results in the manifestation of dyst…
View article: Analysing the clinical relevance and impact of subsidence seen with standalone cages for cervical disc surgeries – A study of fusion rates in 118 patients
Analysing the clinical relevance and impact of subsidence seen with standalone cages for cervical disc surgeries – A study of fusion rates in 118 patients Open
The objective of this study is to examine the short and long term impact of subsidence after anterior cervical discectomy and fusion for compressive cervical disc disease, utilizing solely non-locking stand-alone titanium cage and to analy…
View article: Chloroma – A Rare Case of Metastatic Tumor to Dorsal Spine in Patient of Chronic Myeloid Leukemia Causing Acute Paraparesis
Chloroma – A Rare Case of Metastatic Tumor to Dorsal Spine in Patient of Chronic Myeloid Leukemia Causing Acute Paraparesis Open
Introduction: Chloromas are defined as metastatic granulocytic solid tumors of myeloid origin occurring at an extramedullary site. In this case report, we present an uncommon case of chronic myeloid leukemia (CML) presenting with metastati…
View article: Hematological and biochemical reference intervals of wild-caught and inhouse adult Indian rhesus macaques (Macaca mulatta)
Hematological and biochemical reference intervals of wild-caught and inhouse adult Indian rhesus macaques (Macaca mulatta) Open
Background Nonhuman primates are used for research purposes such as studying diseases and drug discovery and development programs. Various clinical pathology parameters are used as biomarkers of disease conditions in biomedical research. D…
View article: Title: QT Correction Formulae: comparison of different heart rate correction methods in Indian rhesus monkeys
Title: QT Correction Formulae: comparison of different heart rate correction methods in Indian rhesus monkeys Open
Rhesus monkeys are a non-rodent species employed in the preclinical safety evaluation of pharmaceuticals and biologics. These nonhuman primate species have been increasingly used in biomedical research because of the similarity in their io…
View article: Hematological and biochemical reference intervals of wild-caught and inhouse adult Indian rhesus macaques
Hematological and biochemical reference intervals of wild-caught and inhouse adult Indian rhesus macaques Open
Background Nonhuman primates are essentially used for research purposes such as studying diseases, different biological processes and in drug discovery and development programs. Various clinical pathology parameters are used as biomarkers …
View article: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral NLRP3 Inflammasome Inhibitor ZYIL1: First‐in‐Human Phase 1 Studies (Single Ascending Dose and Multiple Ascending Dose)
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral NLRP3 Inflammasome Inhibitor ZYIL1: First‐in‐Human Phase 1 Studies (Single Ascending Dose and Multiple Ascending Dose) Open
ZYIL1 is a nucleotide‐binding oligomerization domain, leucine rich repeat and pyrin domain‐containing 3 (NLRP3) inflammasome inhibitor, which prevents NLRP3‐induced apoptosis‐associated speck‐like protein containing a caspase activation an…
View article: Repurposing dimethyl fumarate for gastric ulcer and ulcerative colitis: Evidence of local efficacy without systemic side effect
Repurposing dimethyl fumarate for gastric ulcer and ulcerative colitis: Evidence of local efficacy without systemic side effect Open
View article: The Evaluation of the Antibacterial and Antifungal Efficacy of Novel Kids Mineral Trioxide Aggregate (e-MTA) With ProRoot MTA and Glass Ionomer Cement
The Evaluation of the Antibacterial and Antifungal Efficacy of Novel Kids Mineral Trioxide Aggregate (e-MTA) With ProRoot MTA and Glass Ionomer Cement Open
Background Most pulpal and periapical problems could be treated nonsurgically. However, in cases of infections, certain operations must be performed that require using materials with good antibacterial and antifungal efficacy. ProRoot mine…
View article: Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor
Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor Open
View article: Optimisation of Momelotinib with Improved Potency and Efficacy as Pan-Jak Inhibitor
Optimisation of Momelotinib with Improved Potency and Efficacy as Pan-Jak Inhibitor Open
View article: Prolyl hydroxylase inhibitor desidustat improves anemia in erythropoietin hyporesponsive state
Prolyl hydroxylase inhibitor desidustat improves anemia in erythropoietin hyporesponsive state Open
View article: Detection of Spinal TB Infection: A Retrospective Study Evaluating Comparative Diagnostic Efficacy of AFB Smear, Gene Expert, Histopathology, Culture Sensitivity and LPA Tests From a Biopsy Sample
Detection of Spinal TB Infection: A Retrospective Study Evaluating Comparative Diagnostic Efficacy of AFB Smear, Gene Expert, Histopathology, Culture Sensitivity and LPA Tests From a Biopsy Sample Open
Background: Spinal Tuberculosis (TB) is one of the significant health dangers that affect the general wellbeing of an individual. It is one of the most common form of extra pulmonary tuberculosis that affects the general population. Diagno…
View article: CCDC 1529818: Experimental Crystal Structure Determination
CCDC 1529818: Experimental Crystal Structure Determination Open
View article: Discovery of a potent G-protein-coupled receptor 119 agonist for the treatment of type 2 diabetes
Discovery of a potent G-protein-coupled receptor 119 agonist for the treatment of type 2 diabetes Open
View article: Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor
Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor Open