Mulin Liu
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View article: Esophagojejunal Anastomosis After Totally Laparoscopic Total Gastrectomy: π-shaped Versus Reverse Puncture Device Anastomosis
Esophagojejunal Anastomosis After Totally Laparoscopic Total Gastrectomy: π-shaped Versus Reverse Puncture Device Anastomosis Open
AIM: This study aimed to compare the advantages of π-shaped anastomosis with reverse puncture device (RPD) anastomosis following totally laparoscopic total gastrectomy (TLTG). METHODS: Clinical data from 133 patients with gastric cancer wh…
View article: TRPML2 channel modulation by PI(3,5)P₂ and small-molecule agonists controls endosomal vesicle dynamics
TRPML2 channel modulation by PI(3,5)P₂ and small-molecule agonists controls endosomal vesicle dynamics Open
TRPML2 is an endolysosomal calcium-permeable channel gated by phosphatidylinositol 3,5-bisphosphate (PI(3,5)P₂). However, its subcellular localization and functional contribution to compartment-specific vesicle trafficking remain incomplet…
View article: [High expression of CRTAC1 promotes proliferation, migration and immune cell infiltration of gastric cancer by regulating the PI3K/AKT signaling pathway].
[High expression of CRTAC1 promotes proliferation, migration and immune cell infiltration of gastric cancer by regulating the PI3K/AKT signaling pathway]. Open
High expression of CRTAC1 in GC tissues affects immunotherapeutic efficacy and prognosis of the patients, possibly by promoting epithelial-mesenchymal transition via modulating tumor mutational load, tumor microenvironment, and the PI3K/AK…
View article: Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report
Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report Open
BACKGROUND Gallbladder neuroendocrine carcinoma (NEC) represents a subtype of gallbladder malignancies characterized by a low incidence, aggressive nature, and poor prognosis. Despite its clinical severity, the genetic alterations, mechani…
View article: Advancements in the clinical application of gene methylation for early cancer detection
Advancements in the clinical application of gene methylation for early cancer detection Open
This review provides an overview of common assays used to screen for gene methylation and early biomarkers of methylation in various cancers. DNA methylation, one of the most well-studied epigenetic modifications, plays a crucial role in n…
View article: Establishment of a prognostic signature for pancreatic cancer using immune checkpoint-related lncRNAs
Establishment of a prognostic signature for pancreatic cancer using immune checkpoint-related lncRNAs Open
Objective: This study aimed to develop a prognostic signature for pancreatic cancer (PC) using immune checkpoint-related long non-coding RNAs (lncRNAs) and evaluate their clinical significance in PC patients. Methods: Transcriptome data an…
View article: Mechanism of Wenyang Shengji Ointment in treating diabetic wounds based on network pharmacology and animal experiments
Mechanism of Wenyang Shengji Ointment in treating diabetic wounds based on network pharmacology and animal experiments Open
Objective: To explore the mechanism of Wenyang Shengji Ointment (温阳生肌膏, WYSJO) in the treatment of diabetic wounds from the perspective of network pharmacology, and to verify it by animal experiments. Methods: The Traditional Chinese Medic…
View article: The digital economy brings new opportunities for arts and culture
The digital economy brings new opportunities for arts and culture Open
We are currently in the digital era of the 21st century, and the rapid advancement of artificial intelligence has brought new energy to the evolution of museums. Museums must inevitably advance towards digitisation. Therefore, the variety …
View article: BRMS1L confers anticancer activity in non-small cell lung cancer by transcriptionally inducing a redox imbalance in the GPX2-ROS pathway
BRMS1L confers anticancer activity in non-small cell lung cancer by transcriptionally inducing a redox imbalance in the GPX2-ROS pathway Open
Low expression levels of breast cancer metastasis suppressor 1 like (BRMS1L) have been associated with the growth of cancer cells. However, the mechanisms underlying the role of BRMS1L as an antitumour transcription factor in the progressi…
View article: A sialyltransferases-related gene signature serves as a potential predictor of prognosis and therapeutic response for bladder cancer
A sialyltransferases-related gene signature serves as a potential predictor of prognosis and therapeutic response for bladder cancer Open
Background Aberrant glycosylation, catalyzed by the specific glycosyltransferase, is one of the dominant features of cancers. Among the glycosyltransferase subfamilies, sialyltransferases (SiaTs) are an essential part which has close linka…
View article: Microstructural origins of high strength of Al–Si alloy manufactured by laser powder bed fusion: In-situ synchrotron radiation X-ray diffraction approach
Microstructural origins of high strength of Al–Si alloy manufactured by laser powder bed fusion: In-situ synchrotron radiation X-ray diffraction approach Open
The microstructural factors contributing to the high strength of additive-manufactured Al–Si alloys using laser-beam powder bed fusion (PBF-LB) were identified by in-situ synchrotron X-ray diffraction in tensile deformation and transmissio…
View article: Functional investigation and two-sample Mendelian randomization study of non-alcoholic fatty liver disease hub genes obtained by WGCNA
Functional investigation and two-sample Mendelian randomization study of non-alcoholic fatty liver disease hub genes obtained by WGCNA Open
Objective: Non-alcoholic fatty liver disease (NAFLD) poses significant health risks, including the potential progression to more severe liver conditions such as liver fibrosis, cirrhosis, and even hepatocellular carcinoma, but its underlyi…
View article: AURKB is a key to connect oxidative phosphorylation and immune microenvironment in Gastric Cancer.
AURKB is a key to connect oxidative phosphorylation and immune microenvironment in Gastric Cancer. Open
The oxidative phosphorylation(OXPHOS) is one of the important activities and plays an important role in the development of tumor. This study combines transcriptome and clinical data from gastric cancer(GC) patients from the GEO and TCGA da…
View article: Establishment of a prognostic signature for hepatocellular carcinoma using disulfidptosis-related lncRNAs
Establishment of a prognostic signature for hepatocellular carcinoma using disulfidptosis-related lncRNAs Open
Background Disulfidptosis is a recently discovered form of programmed cell death that may be a new direction in tumor treatment. Long non-coding RNAs (lncRNAs) play an important role in the development and progression of hepatocellular car…
View article: Identification and validation of a novel redox- related differentially expressed lncRNA prognostic signature for predicting clinical immunotherapy response in gastric cancer
Identification and validation of a novel redox- related differentially expressed lncRNA prognostic signature for predicting clinical immunotherapy response in gastric cancer Open
Redox responses modulated by intracellular long noncoding RNA (lncRNA) can be involved in tumorigenesis and progression. However, the role of redox-related lncRNAs (RRlncRNAs) in gastric cancer (GC) development remains mostly unknown. Our …
View article: Bryostatin‐1 attenuates intestinal ischemia/reperfusion‐induced intestinal barrier dysfunction, inflammation, and oxidative stress via activation of Nrf2/HO‐1 signaling
Bryostatin‐1 attenuates intestinal ischemia/reperfusion‐induced intestinal barrier dysfunction, inflammation, and oxidative stress via activation of Nrf2/HO‐1 signaling Open
Bryostatin‐1 (Bryo‐1) exerts antioxidative stress effects in multiple diseases, and we confirmed that it improves intestinal barrier dysfunction in experimental colitis. Nevertheless, there are few reports on its action on intestinal ische…
View article: Targeted-Gene Sequencing and Bioinformatics Analysis of Patients with Gallbladder Neuroendocrine Carcinoma: A Case Report and Literature Review
Targeted-Gene Sequencing and Bioinformatics Analysis of Patients with Gallbladder Neuroendocrine Carcinoma: A Case Report and Literature Review Open
Background: Gallbladder Neuroendocrine carcinomas (NEC) is a subtype of gallbladder malignant tumour that is characterized by low incidence, high malignancy and poor prognosis. To date, the genetic alterations, mechanistic relationships am…
View article: Identification of significant genes associated with prognosis of gastric cancer by bioinformatics analysis
Identification of significant genes associated with prognosis of gastric cancer by bioinformatics analysis Open
Background Gastric cancer (GC) ranks second in mortality among all malignant diseases worldwide. However, the cause and molecular mechanism underlying gastric cancer are not clear. Here, we used integrated bioinformatics to identify possib…
View article: Integrative proteomics and m6A microarray analyses of the signatures induced by METTL3 reveals prognostically significant in gastric cancer by affecting cellular metabolism
Integrative proteomics and m6A microarray analyses of the signatures induced by METTL3 reveals prognostically significant in gastric cancer by affecting cellular metabolism Open
METTL3-mediated RNA N6-methyladenosine (m6A) is the most prevalent modification that participates in tumor initiation and progression via governing the expression of their target genes in cancers. However, its role in tumor cell metabolism…
View article: surMagnetic nanoparticles detection of C-Reactive Protein combined with neutrophil to lymphocyte ratio to predict the occurrence of anastomotic fistula after rectal cancer surgery
surMagnetic nanoparticles detection of C-Reactive Protein combined with neutrophil to lymphocyte ratio to predict the occurrence of anastomotic fistula after rectal cancer surgery Open
It aimed to explore the effect of C-reactive protein (CRP) combined with neutrophil to lymphocyte ratio (NLR) in the early prediction of anastomotic leakage (AL) after rectal cancer surgery and to improve the prediction accuracy. In this s…
View article: RP11-79H23.3 Inhibits the Proliferation and Metastasis of Non-small-cell Lung Cancer Through Promoting miR-29c
RP11-79H23.3 Inhibits the Proliferation and Metastasis of Non-small-cell Lung Cancer Through Promoting miR-29c Open
Evidences indicate that long non-coding RNAs (lncRNAs) are closely involved and contributed to tumorigenesis and cancer progression. As a novel lncRNA, RP11-79H23.3 was found to be an anti-oncogene in bladder cancer. However, the essential…
View article: Impact of an Intelligent Screening App on Drug Clinical Trial Screening Process during the COVID-19 Pandemic: An Experimental Study (Preprint)
Impact of an Intelligent Screening App on Drug Clinical Trial Screening Process during the COVID-19 Pandemic: An Experimental Study (Preprint) Open
BACKGROUND During the COVID-19 pandemic, clinical trial recruitment cannot be carried out due to travel restrictions, transmission risks and other factors, resulting in the stagnation of a large number of ongoing or upcoming clinical tria…
View article: Identification and Validation of METTL3-Related Molecules for Predicting Prognosis and Efficacy of Immunotherapy in Gastric Cancer Based on m6A Methylome and Transcriptome Sequencing Analysis
Identification and Validation of METTL3-Related Molecules for Predicting Prognosis and Efficacy of Immunotherapy in Gastric Cancer Based on m6A Methylome and Transcriptome Sequencing Analysis Open
Abnormal N6-methyladenosine (m6A) modification levels caused by METTL3 have been identified to be a critical regulator in human cancers, and its roles in the immune microenvironment and the relationship between targeted therapy and immunot…
View article: Clinical Diagnosis, Treatment, and Laboratory Detection of 50 Cases of Pulmonary Cryptococcosis
Clinical Diagnosis, Treatment, and Laboratory Detection of 50 Cases of Pulmonary Cryptococcosis Open
Objective. This study retrospectively analyzed the clinical diagnosis, treatment process, and laboratory test data of patients with pulmonary cryptococcosis to improve the understanding and diagnosis and treatment ability of the disease. M…
View article: Kerr nonlinear medium assisted double-face absorbers for differential manipulation via an all-optical operation
Kerr nonlinear medium assisted double-face absorbers for differential manipulation via an all-optical operation Open
Recently, light absorbers have attracted great attentions due to their promising in applications in functional optoelectronic devices. Herein, we theoretically propose and numerically demonstrate a new absorber platform, which consists of …
View article: m7G-Related DNA Damage Repair Genes are Potential Biomarkers for Predicting Prognosis and Immunotherapy Effectiveness in Colon Cancer Patients
m7G-Related DNA Damage Repair Genes are Potential Biomarkers for Predicting Prognosis and Immunotherapy Effectiveness in Colon Cancer Patients Open
Objective: m 7 G is a post-transcriptional modification modality, however, limited research has been conducted on its role in colon cancer. DNA damage repair (DDR) is an important factor that contributes to colon cancer development, growth…