Masumi Ichikawa
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View article: Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex
Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex Open
Rheb is a small GTP-binding protein and its GTPase activity is activated by the complex of Tsc1 and Tsc2 whose mutations cause tuberous sclerosis complex (TSC). We previously reported that cultured TSC neurons showed impaired spine synapse…