Matloob Ahmad
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View article: Synthesis, in vitro and in silico investigations of coumarin-benzamide hybrid molecules as urease inhibitors
Synthesis, in vitro and in silico investigations of coumarin-benzamide hybrid molecules as urease inhibitors Open
Enzymes play significant role in a variety of biochemical reactions. Urease is an enzyme that catalyzes the hydrolysis of urea into ammonia and carbamate. Its importance is especially evident in the context of Helicobacter pylori infection…
View article: Catalytic multicomponent synthesis of imidazopyrimidine derivatives: an updated review
Catalytic multicomponent synthesis of imidazopyrimidine derivatives: an updated review Open
Fused imidazopyrimidine nucleus constitutes an important class of heterocyclic compounds in organic chemistry. Imidazopyrimidine consists of imidazole and pyrimidine ring, both of which are present in natural products such as folic acid an…
View article: Facile Synthesis of 4-(Methoxycarbonyl)phenyl 5-Arylfuran-2-Carboxylates via Readily Available Pd Catalyst–Their Thermodynamic, Spectroscopic Features and Nonlinear Optical Behavior
Facile Synthesis of 4-(Methoxycarbonyl)phenyl 5-Arylfuran-2-Carboxylates via Readily Available Pd Catalyst–Their Thermodynamic, Spectroscopic Features and Nonlinear Optical Behavior Open
In this work, we described the synthesis of 4-(methoxycarbonyl)phenyl 5-bromofuran-2-carboxylate by reacting 5-bromofuroic acid with methylparaben in the incorporation of DCC/DMAP (Steglich esterification) as coupling agents. Later on, we …
View article: Development of a superhydrophobic concrete coating: Using paper sludge ash and lignosulfonate adhesive
Development of a superhydrophobic concrete coating: Using paper sludge ash and lignosulfonate adhesive Open
In the contemporary construction, concrete stands out as a prominent material, recognized for its widespread utilization across the globe. Despite its remarkable performance in structures over the past three decades, concrete remains susce…
View article: Facile synthesis of aminobiphenyl sulfonamides via Chan–Lam coupling and their biological evaluation as potent carbonic anhydrase inhibitors
Facile synthesis of aminobiphenyl sulfonamides via Chan–Lam coupling and their biological evaluation as potent carbonic anhydrase inhibitors Open
Inhibition of carbonic anhydrases (EC 4.2.1.1, hCAs) is known to be a potential target for treatment of several disorders like epilepsy, glaucoma, obesity, and cancer. The current research focuses on the synthesis of a series of 4'-amino-[…
View article: Recent progress in the synthesis of imidazoquinoline derivatives
Recent progress in the synthesis of imidazoquinoline derivatives Open
Heterocyclic compounds, ubiquitous in nature and on the synthetic scale, are crucial as they acquire a wide spectrum of significant pharmacological properties. Imidazoquinolines, formed by the annulation of imidazole and quinoline rings do…
View article: Synthesis of Anti‐Alzheimer Molecules: Bridging Chemical Approaches to Pharmaceuticals
Synthesis of Anti‐Alzheimer Molecules: Bridging Chemical Approaches to Pharmaceuticals Open
Alzheimer's disease (AD) is a prevalent indication of dementia syndrome. The dementia syndrome commonly manifests as AD. The 2019 World Alzheimer's Report estimates that there are over 50 million people worldwide who have dementia, and tha…
View article: Digital Information Overload and Its Impact on Library Users: Assessing User Experience and Service Adaptations in Female Higher Education Students
Digital Information Overload and Its Impact on Library Users: Assessing User Experience and Service Adaptations in Female Higher Education Students Open
The phenomenon of information overkill is a growing challenge in the age of the ever-increasing digital landscape, as its management is considerably complex for library users. Moreover, owing to the increasing volume of digital resources, …
View article: Preliminary evaluation of the anti-acne potential of herbal and fruit extracts and formulated creams
Preliminary evaluation of the anti-acne potential of herbal and fruit extracts and formulated creams Open
The objective of the research was to evaluate the antibacterial efficacy of the selected herbal and fruit extracts against acne-causing bacteria and then to prepare effective anti-acne creams. People aged 15 to 19 were selected for taking …
View article: Catalytic pathways for N-arylation of benzimidazoles: A comprehensive review
Catalytic pathways for N-arylation of benzimidazoles: A comprehensive review Open
The N-arylated benzimidazoles are important structural motifs in many biologically active compounds. Due to their distinct physicochemical and structural features, they have applications in a wide range of domains, including pharmaceutical…
View article: Synthetic routes for N-arylation of carbazole derivatives and their applications as organic materials
Synthetic routes for N-arylation of carbazole derivatives and their applications as organic materials Open
Carbazole is a heterocyclic aromatic organic compound that has vast applications in pharmaceuticals, and in biological and material sciences. Carbazole derivatives show various biological activities such as antibiotic, anti-inflammatory, a…
View article: Pyridylpiperazine-based carbodithioates as urease inhibitors: synthesis and biological evaluation
Pyridylpiperazine-based carbodithioates as urease inhibitors: synthesis and biological evaluation Open
The urease enzyme is recognized as a valuable therapeutic agent for treating the virulent Helicobacter pylori bacterium because of its pivotal role in aiding the colonization and growth of the bacterium within the gastric mucosa. In order …
View article: Furo[3,2-b]pyridine: Chemical synthesis, transformations and biological applications
Furo[3,2-b]pyridine: Chemical synthesis, transformations and biological applications Open
The combination of heterocycles renders a new possibility to synthesize multicyclic compounds having improved biological activities. Furo[3,2-b]pyridine is a fused heterocyclic ring system comprising a furan ring attached at the third and …
View article: A Comprehensive Update of Anti-COVID-19 Activity of Heterocyclic Compounds
A Comprehensive Update of Anti-COVID-19 Activity of Heterocyclic Compounds Open
The Coronavirus disease 2019 (COVID-19) pandemic is one of the most considerable health problems across the world. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the major causative agent of COVID-19. The severe symptoms o…
View article: N-Arylpyrazole based Scaffolds: Synthesis and biological applications
N-Arylpyrazole based Scaffolds: Synthesis and biological applications Open
N-Arylpyrazoles are important building blocks in many biologically active compounds, natural products, pharmaceuticals, and industries. It is an important moiety of various drugs and exhibits extensive biological activities viz., antibioti…
View article: The antihyperglycemic potential of pyrazolobenzothiazine 1, 1-dioxide novel derivative in mice using integrated molecular pharmacological approach
The antihyperglycemic potential of pyrazolobenzothiazine 1, 1-dioxide novel derivative in mice using integrated molecular pharmacological approach Open
Diabetes Mellitus is a metabolic disease characterized by elevated blood sugar levels caused by inadequate insulin production, which subsequently leads to hyperglycemia. This study was aimed to investigate the antidiabetic potential of pyr…
View article: Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors
Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors Open
Urease, a nickel-dependent enzyme found in various life forms, catalyzes urea breakdown, concluding nitrogen metabolism by generating ammonia and carbamate. This process causes a rise in pH, supports the survival of pathogens, and can lead…
View article: Halloysite nanotubes-enhanced epoxy acrylate latex emulsion as a novel anticorrosive protective coating for metal surface in 3.5% NaCl solution
Halloysite nanotubes-enhanced epoxy acrylate latex emulsion as a novel anticorrosive protective coating for metal surface in 3.5% NaCl solution Open
Corrosion is a major problem that can lead to the degradation of metal structures. In this study, we developed a novel corrosion-protective coating for metal substrates based on a modified epoxy acrylate formulation reinforced with halloys…
View article: The role of commonly used transition metals in total synthesis of indole alkaloids
The role of commonly used transition metals in total synthesis of indole alkaloids Open
This Paper reviews the most recent advances in synthesizing indole alkaloids using transition metal-catalyzed methods. The essential class of natural substances known as indole alkaloids has several biological effects, including anti-infla…
View article: Unveiling the Role of Nonionic Surfactants in Enhancing Cefotaxime Drug Solubility: A UV-Visible Spectroscopic Investigation in Single and Mixed Micellar Formulations
Unveiling the Role of Nonionic Surfactants in Enhancing Cefotaxime Drug Solubility: A UV-Visible Spectroscopic Investigation in Single and Mixed Micellar Formulations Open
This study reports the interfacial phenomenon of cefotaxime in combination with nonionic surfactants, Triton X-100 (TX-100) and Tween-80 (TW-80), and their mixed micellar formulations. Cefotaxime was enclosed in a micellar system to improv…
View article: Triazoloquinazoline: Synthetic Strategies and Medicinal Importance
Triazoloquinazoline: Synthetic Strategies and Medicinal Importance Open
Triazoloquinazoline is a fused heterocyclic nucleus, formed by the fusion of two fundamental heterocyclic moieties; triazole and quinazoline. This class of compound is known for its potential as a therapeutic agent and is endowed with seve…
View article: Recent Approaches for the Synthesis of Imidazoquinazolines and Benzimidazoquinazolines
Recent Approaches for the Synthesis of Imidazoquinazolines and Benzimidazoquinazolines Open
Heterocyclic ring systems are gaining attention due to their pivotal role in drug design and medicinal chemistry. Quinazolines are nitrogen-containing heterocyclic pharmacophoric units found in abundance in natural and pharmaceutical produ…
View article: Recent advances in the piperazine based antiviral agents: A remarkable heterocycle for antiviral research
Recent advances in the piperazine based antiviral agents: A remarkable heterocycle for antiviral research Open
A growing interest in pharmacology has made heterocyclic chemistry as one of the emerging branches of organic chemistry. Piperazine is an excellent heterocycle that possesses a large span of pharmaceutical applications. Piperazine derived …
View article: The antihyperglycemic potential of pyraozolobenzothiazine 1,1-dioxide novel derivative in mice using integrated molecular pharmacological approach
The antihyperglycemic potential of pyraozolobenzothiazine 1,1-dioxide novel derivative in mice using integrated molecular pharmacological approach Open
Diabetes Mellitus (DM) is a extensively studied metabolic disease characterized by elevated blood sugar levels caused by inadequate insulin production, which subsequently leads to hyperglycemia. This study was intended to investigate the i…
View article: Synthesis, Anti-Bacterial and Molecular Docking Studies of Arylated Butyl 2-Bromoisonicotinate Against Clinical Isolates of ESBL-Producing Escherichia coli ST405 and Methicillin-Resistant Staphylococcus aureus
Synthesis, Anti-Bacterial and Molecular Docking Studies of Arylated Butyl 2-Bromoisonicotinate Against Clinical Isolates of ESBL-Producing Escherichia coli ST405 and Methicillin-Resistant Staphylococcus aureus Open
The butyl 2-bromoisonicotinate displayed antibacterial efficacy against ESBL-producing E. coli ST405 and MRSA strains. After the in-vivo trial, this substance might offer an alternative therapeutic option.
View article: A Comprehensive Update of Various Attempts by Medicinal Chemists to Combat COVID-19 through Natural Products
A Comprehensive Update of Various Attempts by Medicinal Chemists to Combat COVID-19 through Natural Products Open
The ongoing COVID-19 pandemic has resulted in a global panic because of its continual evolution and recurring spikes. This serious malignancy is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the outbreak…
View article: Recent synthetic strategies of medicinally important imidazothiadiazoles
Recent synthetic strategies of medicinally important imidazothiadiazoles Open
Imidazothiadiazole is a fundamental fused heterocyclic compound containing imidazole and thiadiazole ring systems. This versatile framework has significant applications in pharmaceutical chemistry and also possessed a remarkable biological…
View article: Enhanced solubilization and encapsulation of direct dyes through self-assembled single and mixed micellar nanocarriers
Enhanced solubilization and encapsulation of direct dyes through self-assembled single and mixed micellar nanocarriers Open
This manuscript provides insights into the solubilization of two direct dyes, direct green 6 (DG-6) and direct yellow 44 (DY-44), in different surfactant systems. It reports the interaction and applicability of surfactants to elevate the s…
View article: Exploring the Antimicrobial and Pharmacological Potential of NF22 as a Potent Inhibitor of E. coli DNA Gyrase: An In Vitro and In Silico Study
Exploring the Antimicrobial and Pharmacological Potential of NF22 as a Potent Inhibitor of E. coli DNA Gyrase: An In Vitro and In Silico Study Open
Toward the search for novel antimicrobial agents to control pathogenic E. coli-associated infections, a series of novel norfloxacin derivatives were screened for antimicrobial activities. The norfloxacin derivative, 1-ethyl-6-fluoro-7-(4-(…