Munish C. Gupta
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View article: Reverse versus anatomic total shoulder arthroplasty in patients over 70 with a competent rotator cuff and glenohumeral osteoarthritis: a meta-analysis
Reverse versus anatomic total shoulder arthroplasty in patients over 70 with a competent rotator cuff and glenohumeral osteoarthritis: a meta-analysis Open
In patients aged ≥70 years with primary GHOA and a competent rotator cuff, aTSA provides superior rotational mobility, exceeding the MCID and potentially supporting improvements in daily activities such as dressing or toileting. rTSA offer…
View article: The contribution of lower limbs to Pelvic Tilt: A baseline and postoperative full-body analysis
The contribution of lower limbs to Pelvic Tilt: A baseline and postoperative full-body analysis Open
This study demonstrated that PT is a phenomenon driven by extension of the hips and flexion of the knees and proposed values to predict PT from those two compensatory mechanisms. Magnitude of spinal deformity and hip OA alters the magnitud…
View article: Ablation of VEGFA following a lumbar intervertebral disc injury attenuates intradiscal neurovascular features and prevents chronic low back pain symptoms
Ablation of VEGFA following a lumbar intervertebral disc injury attenuates intradiscal neurovascular features and prevents chronic low back pain symptoms Open
There are currently no therapies for the staggering disability and public health costs of chronic low back pain (LBP). Innervation of the degenerating intervertebral disc (IVD) is suspected to cause discogenic LBP, but the mechanisms that …
View article: Decision regret in adult spinal deformity surgery: a comparison of SRS-22r outcomes and the Decision Regret Scale
Decision regret in adult spinal deformity surgery: a comparison of SRS-22r outcomes and the Decision Regret Scale Open
OBJECTIVE The Decision Regret Scale (DRS) is a valid instrument evaluating the "correctness" of a treatment decision from the patient perspective. The minimal clinically important difference (MCID) is proposed as a threshold for patient-re…
View article: Impact of thoracolumbar inflection point on outcomes and complications in adult spinal deformity
Impact of thoracolumbar inflection point on outcomes and complications in adult spinal deformity Open
OBJECTIVE Existing literature on the impact of alignment parameters relative to the thoracolumbar inflection point remains sparse. The authors aimed to investigate the influence of the inflection point, lumbar lordosis apex (LLA), and othe…
View article: Comparative Analysis of Outcomes in Adult Spinal Deformity Patients with Proximal Junctional Kyphosis or Failure Initially Fused to Upper Versus Lower Thoracic Spine
Comparative Analysis of Outcomes in Adult Spinal Deformity Patients with Proximal Junctional Kyphosis or Failure Initially Fused to Upper Versus Lower Thoracic Spine Open
Background: Patients with proximal junctional kyphosis (PJK) or failure (PJF) may demonstrate disparate outcomes and recovery when fused to the upper (UT) versus lower (LT) thoracic spine. Few studies have distinguished the reoperation and…
View article: Unsupervised Clustering of Adult Spinal Deformity Patterns Predicts Surgical and Patient-Reported Outcomes
Unsupervised Clustering of Adult Spinal Deformity Patterns Predicts Surgical and Patient-Reported Outcomes Open
Study Design Retrospective cohort study. Objectives To evaluate whether different radiographic clusters of adult spinal deformity identified using artificial intelligence-based clustering are associated with distinct surgical outcomes. Met…
View article: Assessing Abnormal Proximal Junctional Angles in Adult Spinal Deformity
Assessing Abnormal Proximal Junctional Angles in Adult Spinal Deformity Open
Study design. Multicentric retrospective study of prospectively collected data. Objective. On the basis of normative data from a cohort of asymptomatic volunteers, this study sought to determine the rate of abnormal values of proximal junc…
View article: Incremental Increase in Hospital Length of Stay Due to Complications of Surgery for Adult Spinal Deformity
Incremental Increase in Hospital Length of Stay Due to Complications of Surgery for Adult Spinal Deformity Open
Study Design Retrospective Cohort Study. Objectives Length of Stay (LOS) and resource utilization are of primary importance for hospital administration. This study aimed to understand the incremental effect of having a specific complicatio…
View article: Instrumentation Failure in Adult Spinal Deformity Patients
Instrumentation Failure in Adult Spinal Deformity Patients Open
In recent years, advances in the surgical treatment of adult spinal deformity (ASD) have led to improved outcomes. Although these advances have helped drive the development of deformity surgery to meet the rising volume of patients seeking…
View article: The progression of neurovascular features and chemokine signatures of the intervertebral disc with degeneration
The progression of neurovascular features and chemokine signatures of the intervertebral disc with degeneration Open
Inflammatory cytokine production and de novo neurovascularization have been identified in painful, degenerated intervertebral discs (IVDs). However, the temporal trajectories of these key pathoanatomical features, including the cascade of …
View article: Complications and Health-Related Quality of Life in Children with Various Etiologies of Early-Onset Scoliosis Treated with Magnetically Controlled Growing Rods—A Multicenter Study
Complications and Health-Related Quality of Life in Children with Various Etiologies of Early-Onset Scoliosis Treated with Magnetically Controlled Growing Rods—A Multicenter Study Open
Background: Early-onset scoliosis (EOS) refers to spinal deformities that develop and are diagnosed before the age of 10. The most important goals of the surgical treatment of EOS are to stop the progression of curvature, achieve the best …
View article: IGF-1 Peptide Mimetic-functionalized Hydrogels Enhance MSC Survival and Immunomodulatory Activity
IGF-1 Peptide Mimetic-functionalized Hydrogels Enhance MSC Survival and Immunomodulatory Activity Open
Human mesenchymal stem cells (MSCs) have demonstrated promise when delivered to damaged tissue or tissue defects for their cytokine secretion and inflammation modulation behaviors that can promote repair. Insulin-like growth factor 1 (IGF-…
View article: Severe (>100 Degrees) Thoracic Adolescent Idiopathic Scoliosis – A Comparison of Surgical Approaches
Severe (>100 Degrees) Thoracic Adolescent Idiopathic Scoliosis – A Comparison of Surgical Approaches Open
Study Design Retrospective. Objective Severe curves >100° in adolescent idiopathic scoliosis (AIS) are rare and require careful operative planning. The aim of this study was to assess baseline, perioperative, and 2-year differences between…
View article: Reply to Tabeling et al. Comment on “Grabala et al. Radiological Outcomes of Magnetically Controlled Growing Rods for the Treatment of Children with Various Etiologies of Early-Onset Scoliosis—A Multicenter Study. J. Clin. Med. 2024, 13, 1529”
Reply to Tabeling et al. Comment on “Grabala et al. Radiological Outcomes of Magnetically Controlled Growing Rods for the Treatment of Children with Various Etiologies of Early-Onset Scoliosis—A Multicenter Study. J. Clin. Med. 2024, 13, 1529” Open
We are immensely gratified by the considerable interest our study has garnered [...]
View article: Revision Strategy for Proximal Junctional Failure: Combined Effect of Proximal Extension and Focal Correction
Revision Strategy for Proximal Junctional Failure: Combined Effect of Proximal Extension and Focal Correction Open
Study design Retrospective review of a prospectively-collected multicenter database. Objectives The objective of this study was to determine optimal strategies in terms of focal angular correction and length of proximal extension during re…
View article: Impact of Self-Reported Loss of Balance and Gait Disturbance on Outcomes following Adult Spinal Deformity Surgery
Impact of Self-Reported Loss of Balance and Gait Disturbance on Outcomes following Adult Spinal Deformity Surgery Open
Background: The objective of this study was to evaluate if imbalance influences complication rates, radiological outcomes, and patient-reported outcomes (PROMs) following adult spinal deformity (ASD) surgery. Methods: ASD patients with bas…
View article: Radiological Outcomes of Magnetically Controlled Growing Rods for the Treatment of Children with Various Etiologies of Early-Onset Scoliosis—A Multicenter Study
Radiological Outcomes of Magnetically Controlled Growing Rods for the Treatment of Children with Various Etiologies of Early-Onset Scoliosis—A Multicenter Study Open
Background: The management of spinal deformities diagnosed before the age of 10 is critical due to the child’s development, skeletal system, and growth mechanism. Magnetically controlled growing rods (MCGRs) are a surgical treatment option…
View article: Fundamental principle of adult spinal deformity
Fundamental principle of adult spinal deformity Open
The management of adult spinal deformity (ASD) requires a personalized, multidisciplinary approach. Effective treatment hinges on thorough assessment using advanced imaging to understand the severity and impact of the spinal curvature. Thi…
View article: Cost Benefit of Implementation of Risk Stratification Models for Adult Spinal Deformity Surgery
Cost Benefit of Implementation of Risk Stratification Models for Adult Spinal Deformity Surgery Open
Study Design/Setting Retrospective cohort study. Objective Assess the extent to which defined risk factors of adverse events are drivers of cost-utility in spinal deformity (ASD) surgery. Methods ASD patients with 2-year (2Y) data were inc…
View article: Anterior lumbar interbody fusion versus transforaminal lumbar interbody fusion for correction of lumbosacral fractional curves in adult (thoraco)lumbar scoliosis: A systematic review
Anterior lumbar interbody fusion versus transforaminal lumbar interbody fusion for correction of lumbosacral fractional curves in adult (thoraco)lumbar scoliosis: A systematic review Open
Limited level III and IV evidence suggests ALIF as advantageous for reducing the coronal Cobb angle of the LsFC in de novo adult (thoraco) lumbar scoliosis. Relative efficacy of ALIF and TLIF in the LsFC for restoration of global coronal a…
View article: Alterations in Magnitude and Shape of Thoracic Kyphosis Following Surgical Correction for Adult Spinal Deformity
Alterations in Magnitude and Shape of Thoracic Kyphosis Following Surgical Correction for Adult Spinal Deformity Open
Study Design Retrospective review of prospective multicenter data. Objectives This study aimed to investigate the shape of TK before and after fusion in ASD patients treated with long fusion. Methods ASD patients undergoing posterior spina…
View article: Adult Cervical Deformity Patients Have Higher Baseline Frailty, Disability, and Comorbidities Compared With Complex Adult Thoracolumbar Deformity Patients: A Comparative Cohort Study of 616 Patients
Adult Cervical Deformity Patients Have Higher Baseline Frailty, Disability, and Comorbidities Compared With Complex Adult Thoracolumbar Deformity Patients: A Comparative Cohort Study of 616 Patients Open
Study Design Multicenter comparative cohort. Objective Studies have shown markedly higher rates of complications and all-cause mortality following surgery for adult cervical deformity (ACD) compared with adult thoracolumbar deformity (ATLD…
View article: Outcomes of Surgical Treatment for Patients With Mild Scoliosis and Age-Appropriate Sagittal Alignment With Minimum 2-Year Follow-up
Outcomes of Surgical Treatment for Patients With Mild Scoliosis and Age-Appropriate Sagittal Alignment With Minimum 2-Year Follow-up Open
Objective: The goal of this study was to determine if patients with mild scoliosis and age-appropriate sagittal alignment have favorable outcomes following surgical correction.Methods: Retrospective review of a prospective, multicenter adu…
View article: The ISSG-AO Complication Intervention Score, but Not Major/Minor Designation, is Correlated With Length of Stay Following Adult Spinal Deformity Surgery
The ISSG-AO Complication Intervention Score, but Not Major/Minor Designation, is Correlated With Length of Stay Following Adult Spinal Deformity Surgery Open
Study Design Retrospective review. Objectives The International Spine Study Group-AO (ISSG-AO) Adult Spinal Deformity (ASD) Complication Classification System was developed to improve classification, reporting, and study of complications a…
View article: Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery
Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery Open
Background: While reimbursement is centered on 90-day outcomes, many patients may still achieve optimal, long-term outcomes following adult spinal deformity (ASD) surgery despite transient short-term complications. Objective: Compare long-…