Munro Passmore
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View article: Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis
Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis Open
Polyketides and nonribosomal peptides are important natural product classes with wide-ranging medical and agricultural applications. The analogous enzymatic logic employed by bacterial modular polyketide synthases (PKSs) and nonribosomal p…
View article: Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in <i>trans</i>-Acyltransferase Polyketide Synthases
Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in <i>trans</i>-Acyltransferase Polyketide Synthases Open
Polyketide synthases (PKSs) are multidomain enzymatic assembly lines that biosynthesize a wide selection of bioactive natural products from simple building blocks. In contrast to their cis-acyltransferase (AT) counterparts, trans-AT PKSs r…
View article: Molecular basis for short-chain thioester hydrolysis by acyl hydrolase domains in<i>trans</i>-acyltransferase polyketide synthases
Molecular basis for short-chain thioester hydrolysis by acyl hydrolase domains in<i>trans</i>-acyltransferase polyketide synthases Open
Polyketide synthases (PKSs) are multi-domain enzymatic assembly lines that biosynthesise a wide selection of bioactive natural products from simple building blocks. In contrast to their cis -acyltransferase (AT) counterparts, trans -AT PKS…
View article: Elucidating the molecular programming of a nonlinear nonribosomal peptide synthetase responsible for fungal siderophore biosynthesis
Elucidating the molecular programming of a nonlinear nonribosomal peptide synthetase responsible for fungal siderophore biosynthesis Open
Siderophores belonging to the ferrichrome family are essential for the viability of fungal species and play a key role for virulence of numerous pathogenic fungi. Despite their biological significance, our understanding of how these iron-c…
View article: Front Cover: Decoding Protein Gas‐Phase Stability with Alanine Scanning and Collision‐Induced Unfolding Ion Mobility Mass Spectrometry (Analysis & Sensing 1/2021)
Front Cover: Decoding Protein Gas‐Phase Stability with Alanine Scanning and Collision‐Induced Unfolding Ion Mobility Mass Spectrometry (Analysis & Sensing 1/2021) Open
The Front Cover shows collision-induced unfolding (CIU) of an acyl carrier protein in the gas phase as measured by ion mobility spectrometry. The background shows a representation of the alanine scanning mutagenesis used to probe the impor…
View article: Molecular basis for acyl carrier protein–ketoreductase interaction in <i>trans</i>-acyltransferase polyketide synthases
Molecular basis for acyl carrier protein–ketoreductase interaction in <i>trans</i>-acyltransferase polyketide synthases Open
The interaction epitope between a cognate KR–ACP domain pairing from a trans -AT polyketide synthase is elucidated in molecular detail, providing unique insights into recognition and specificity of the interface.
View article: Decoding Protein Gas‐Phase Stability with Alanine Scanning and Collision‐Induced Unfolding Ion Mobility Mass Spectrometry
Decoding Protein Gas‐Phase Stability with Alanine Scanning and Collision‐Induced Unfolding Ion Mobility Mass Spectrometry Open
Native mass spectrometry is a widely used tool in structural biology, providing information on protein structure and interactions through preservation of complexes in the gas phase. Herein, the importance of intramolecular non‐covalent int…