Muntaser E. Ibrahim
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View article: Evidence for infectious merozoites of Plasmodium falciparum from natural isolates of cultured hepatoma cells infected with sporozoites
Evidence for infectious merozoites of Plasmodium falciparum from natural isolates of cultured hepatoma cells infected with sporozoites Open
Previous cell culture systems using various human hepatoma cell lines established that the intra-hepatic stages of Plasmodium falciparum could be studied ex vivo. However, only one of these culture systems yielded infective merozoites that…
View article: Exome Sequencing of a Type 1 Diabetes Mellitus Family Exposes Both Common and Individualized Rare Variants Contributing to Pathogenesis
Exome Sequencing of a Type 1 Diabetes Mellitus Family Exposes Both Common and Individualized Rare Variants Contributing to Pathogenesis Open
Type 1 diabetes mellitus (T1D) is a disease of complex inheritance where genetic, immunological, and environmental factors interact in rendering the ultimate phenotype. To gain insights into the molecular etiology of the disease in a subse…
View article: Hierarchical Genomic Analysis of Susceptibility to Schizophrenia in Sudanese multi-case families
Hierarchical Genomic Analysis of Susceptibility to Schizophrenia in Sudanese multi-case families Open
Background Schizophrenia, with its diverse and complex presentation, is a prime candidate for genetic investigation. Its heritability in both familial and sporadic cases, clinical overlap with other psychiatric conditions, and individual v…
View article: Association Between Toxoplasmosis in Cats and FeLV, FIV in Kuwait State
Association Between Toxoplasmosis in Cats and FeLV, FIV in Kuwait State Open
This study conducted in Animal House Veterinary Hospital Salymia region, Kuwait state and its focuses on the domestic cats because of the majority of families in Kuwait have cats and other pets in their homes and this importance reflected …
View article: Extensive genetic diversity in Plasmodium vivax from Sudan and its genetic relationships with other geographical isolates
Extensive genetic diversity in Plasmodium vivax from Sudan and its genetic relationships with other geographical isolates Open
Plasmodium vivax, traditionally overlooked has experienced a notable increase in cases in East Africa. This study investigated the geographical origin and genetic diversity of P. vivax in Sudan using 14 microsatellite markers. A total of 1…
View article: The Rural-Urban Divide: Insights from Immuno-Genetic Profiles and Implications for Health
The Rural-Urban Divide: Insights from Immuno-Genetic Profiles and Implications for Health Open
Population disparities in health and disease have been observed and amply documented. While often attributable to genetic underpinnings, such disparities extend beyond population genetic predisposition to include environmental and geograph…
View article: The rural urban divide, insights from immuno-genetic profiles and implications for health
The rural urban divide, insights from immuno-genetic profiles and implications for health Open
Population disparities in health and disease, has been observed, and amply documented. While often attributable to genetic underpinnings, such disparities, extends beyond population genetic predisposition to include environmental and geogr…
View article: Follicular Helper and Regulatory T Cells Drive the Development of Spontaneous Epstein–Barr Virus Lymphoproliferative Disorder
Follicular Helper and Regulatory T Cells Drive the Development of Spontaneous Epstein–Barr Virus Lymphoproliferative Disorder Open
Epstein–Barr virus (EBV) is a ubiquitous herpes virus associated with various cancers. EBV establishes latency with life-long persistence in memory B-cells and can reactivate lytic infection placing immunocompromised individuals at risk fo…
View article: Smell Impairmet and Schizophrania: Genotypic and Phenotypc Correlates in a Familial Cohort
Smell Impairmet and Schizophrania: Genotypic and Phenotypc Correlates in a Familial Cohort Open
Background Schizophrenia is a mental disorder in which patients experience altered perception of the world. It has been reported to manifest in smell impairment similar to other neuropsychiatric and neurodegenerative disorders. The sense o…
View article: Clinical phenotyping and genetic diagnosis of a large cohort of Sudanese families with hereditary spinocerebellar degeneration
Clinical phenotyping and genetic diagnosis of a large cohort of Sudanese families with hereditary spinocerebellar degeneration Open
Hereditary spinocerebellar degenerative disorders (SCDs) is an umbrella term that covers a group of monogenic conditions that share common pathogenic mechanisms and include spastic paraplegia, spastic ataxia, cerebellar ataxia, and spinoce…
View article: The Spike Protein of SARS-coV2 19B (S) Clade Mirrors Critical Features of Viral Adaptation and Coevolution
The Spike Protein of SARS-coV2 19B (S) Clade Mirrors Critical Features of Viral Adaptation and Coevolution Open
Pathogens including viruses evolve in tandem with diversity in their animal and human hosts. For SARS-coV2, the focus is generally for understanding such coevolution on the virus spike protein, since it demonstrates high mutation rates com…
View article: Editorial: The path towards precision health: Prospects and challenges
Editorial: The path towards precision health: Prospects and challenges Open
EDITORIAL article Front. Med., 11 October 2022Sec. Precision Medicine Volume 9 - 2022 | https://doi.org/10.3389/fmed.2022.989746
View article: The Spike protein of SARS-coV2 19B (S) clade mirrors critical features of viral adaptation and coevolution
The Spike protein of SARS-coV2 19B (S) clade mirrors critical features of viral adaptation and coevolution Open
Pathogens including viruses evolve in tandem with diversity in their animal and human hosts. For SARS-coV2, the focus is generally for understanding such coevolution on the virus spike protein since it demonstrates high mutation rates comp…
View article: Role of pH in Regulating Cancer Pyrimidine Synthesis
Role of pH in Regulating Cancer Pyrimidine Synthesis Open
Replication is a fundamental aspect of cancer, and replication is about reproducing all the elements and structures that form a cell. Among them are DNA, RNA, enzymes, and coenzymes. All the DNA is doubled during each S (synthesis) cell cy…
View article: Establishment of regional genomic surveillance networks in lower and lower-middle income countries
Establishment of regional genomic surveillance networks in lower and lower-middle income countries Open
This is a position letter that represents the stance of the members of the UNESCO-TWAS Advisory Committee on COVID-19, who come from various countries in the Global South. It addresses the disparity in SARS-CoV-2 genomic data between diffe…
View article: Individualized Medicine in Africa: Bringing the Practice Into the Realms of Population Heterogeneity
Individualized Medicine in Africa: Bringing the Practice Into the Realms of Population Heterogeneity Open
The declared aim of “personalized”, “stratified” or “precision” approaches is to place individual variation, as ascertained through genomic and various other biomarkers, at the heart of Scientific Medicine using it to predict risk of disea…
View article: Breast Cancer and Smell: Hints from Epigenetic and Functional Alteration of the Olfaction
Breast Cancer and Smell: Hints from Epigenetic and Functional Alteration of the Olfaction Open
Purpose: Olfactory receptors are G protein coupled surface receptors (GPCRs) of which their ectopic expression is currently of mounting interest to the development and metastasis of malignancies. These genes having a direct contact with th…
View article: Pathogenic Variants in ABHD16A Cause a Novel Psychomotor Developmental Disorder With Spastic Paraplegia
Pathogenic Variants in ABHD16A Cause a Novel Psychomotor Developmental Disorder With Spastic Paraplegia Open
Introduction: Hereditary spastic paraplegia is a clinically and genetically heterogeneous neurological entity that includes more than 80 disorders which share lower limb spasticity as a common feature. Abnormalities in multiple cellular pr…
View article: Pathogenesis and Management of COVID-19
Pathogenesis and Management of COVID-19 Open
COVID-19, occurring due to SARS-COV-2 infection, is the most recent pandemic disease that has led to three million deaths at the time of writing. A great deal of effort has been directed towards altering the virus trajectory and/or managin…
View article: Genetic diversity of the Sudanese: insights on origin and implications for health
Genetic diversity of the Sudanese: insights on origin and implications for health Open
By virtue of their cultural, linguistic and genetic legacies, many populations from Sudan have deep histories in the region and retain high genetic diversities. Sudan’s location in north east Africa, a unique spot believed to act as a clim…
View article: Efficient Annotation of Variant Calls: Next Generation Sequencing
Efficient Annotation of Variant Calls: Next Generation Sequencing Open
The tremendous and unprecedented insights provided by next generation sequencing into genome functions, variations and interactions promises an enormous shift in our attitude towards individual and population genetics, both in health and d…
View article: Of mitochondrion and COVID-19
Of mitochondrion and COVID-19 Open
COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfuncti…
View article: In silico analysis of single nucleotide polymorphisms (SNPs) in human C-C chemokine receptor type five (CCR5) gene
In silico analysis of single nucleotide polymorphisms (SNPs) in human C-C chemokine receptor type five (CCR5) gene Open
Introduction Chemokines are small transmembrane proteins with immune surveillance and immune cell recruitment functions. the expression of CCR5 gene affects virus production and viral load(1). The CCR5 gene contains two introns, three exon…
View article: Novel Homozygous Missense Mutation in the ARG1 Gene in a Large Sudanese Family
Novel Homozygous Missense Mutation in the ARG1 Gene in a Large Sudanese Family Open
Background: Arginases catalyze the last step in the urea cycle. Hyperargininemia, a rare autosomal-recessive disorder of the urea cycle, presents after the first year of age with regression of milestones and evolves gradually into progress…