Murali Varma
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View article: Personalized prostate pathology reporting: Focus on communication and clinical utility
Personalized prostate pathology reporting: Focus on communication and clinical utility Open
Histopathology parameters are generally critical for the management of prostate cancer. Current practice is focussed on accuracy, precision, reproducibility, standardization and completeness of this data collection. This review discusses i…
View article: The Genitourinary Pathology Society and International Society of Urological Pathology Joint Expert Consultation Recommendations on intraductal carcinoma of the prostate
The Genitourinary Pathology Society and International Society of Urological Pathology Joint Expert Consultation Recommendations on intraductal carcinoma of the prostate Open
Conflicting practice recommendations regarding the grading of intraductal carcinoma of the prostate (IDCP) from two leading uropathology societies, the Genitourinary Pathology Society (GUPS) and the International Society of Urological Path…
View article: Architecting for Digital Inclusion: Building and Training for Accessible Web Systems at Scale
Architecting for Digital Inclusion: Building and Training for Accessible Web Systems at Scale Open
Digital inclusion has emerged as a critical architectural consideration in modern web development, fundamentally reshaping how organizations approach system design and implementation. This article presents a comprehensive framework for bui…
View article: Prevalence of allergens in children: a single centre experience
Prevalence of allergens in children: a single centre experience Open
Background: The exact epidemiological data on the allergic disorders, food sensitization and probable food allergy in Indian children is lacking. In this study, as an attempt to address the paucity of data in Indian children, the clinical …
View article: Impact of the diagnostic label for a low-risk prostate lesion: protocol for two online factorial randomised experiments
Impact of the diagnostic label for a low-risk prostate lesion: protocol for two online factorial randomised experiments Open
Introduction Many types of prostate cancer present minimal risk to a man’s lifespan or well-being, but existing terminology makes it difficult for men to distinguish these from high-risk prostate cancers. This study aims to explore whether…
View article: Web‐grading—a tool to test personal grading of renal and prostate cancer
Web‐grading—a tool to test personal grading of renal and prostate cancer Open
Only a few pathologists have the opportunity to verify their personal grading through objective assessment. This study introduces a web‐based grading platform to facilitate and validate the grading of renal cell carcinoma and prostate canc…
View article: International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members
International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members Open
Grading of non-muscle-invasive bladder cancer (NMIBC) is a matter of ongoing debate and lacks international consensus. We surveyed urologists and pathologists of European Association of Urology and International Society of Urological Patho…
View article: Low‐risk prostate lesions: An evidence review to inform discussion on losing the “cancer” label
Low‐risk prostate lesions: An evidence review to inform discussion on losing the “cancer” label Open
Background Active surveillance (AS) mitigates harms from overtreatment of low‐risk prostate lesions. Recalibration of diagnostic thresholds to redefine which prostate lesions are considered “cancer” and/or adopting alternative diagnostic l…
View article: Measuring cancer burden in prostatic needle core biopsies: simplified assessments outperform complex measurements in assessing outcome: evidence to assist pathologist efficiency and minimize datasets
Measuring cancer burden in prostatic needle core biopsies: simplified assessments outperform complex measurements in assessing outcome: evidence to assist pathologist efficiency and minimize datasets Open
Aims The optimal method of measuring cancer extent in prostate cancer (PCa) biopsies is unknown. Methods and Results Nine hundred eighty‐one men with clinically localised PCa managed conservatively were reviewed with follow up. The number …
View article: Reporting Trends, Practices, and Resource Utilization in Neuroendocrine Tumors of the Prostate Gland: A Survey among Thirty-Nine Genitourinary Pathologists
Reporting Trends, Practices, and Resource Utilization in Neuroendocrine Tumors of the Prostate Gland: A Survey among Thirty-Nine Genitourinary Pathologists Open
Background. Neuroendocrine differentiation in the prostate gland ranges from clinically insignificant neuroendocrine differentiation detected with markers in an otherwise conventional prostatic adenocarcinoma to a lethal high-grade small/l…
View article: Measuring cancer burden in prostatic needle core biopsies: Simplified assessments outperform complex measurements in assessing outcome: evidence to assist pathologist efficiency and minimise datasets.
Measuring cancer burden in prostatic needle core biopsies: Simplified assessments outperform complex measurements in assessing outcome: evidence to assist pathologist efficiency and minimise datasets. Open
981 men with clinically localized prostate cancer diagnosed and managed conservatively were centrally reviewed by two uropathologists. Follow up was through cancer registries up until 2012. Deaths were divided into those from PC and those …
View article: Diagnosis of "cribriform" prostatic adenocarcinoma: an interobserver reproducibility study among urologic pathologists with recommendations.
Diagnosis of "cribriform" prostatic adenocarcinoma: an interobserver reproducibility study among urologic pathologists with recommendations. Open
Accurate diagnosis of cribriform Gleason pattern 4 (CrP4) prostate adenocarcinoma (PCa) is important due to its independent association with adverse clinical outcomes and as a growing body of evidence suggests that it impacts clinical deci…
View article: Head to head: should the intraductal component of invasive prostate cancer be graded?
Head to head: should the intraductal component of invasive prostate cancer be graded? Open
The reporting of intraductal carcinoma of the prostate (IDCP) is controversial, with conflicting recommendations having recently been published by the International Society of Urological Pathology (ISUP) and the Genitourinary Pathology Soc…
View article: Identification of areas of grading difficulties in prostate cancer and comparison with artificial intelligence assisted grading
Identification of areas of grading difficulties in prostate cancer and comparison with artificial intelligence assisted grading Open
The International Society of Urological Pathology (ISUP) hosts a reference image database supervised by experts with the purpose of establishing an international standard in prostate cancer grading. Here, we aimed to identify areas of grad…
View article: The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma
The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma Open
Five years after the last prostatic carcinoma grading consensus conference of the International Society of Urological Pathology (ISUP), accrual of new data and modification of clinical practice require an update of current pathologic gradi…
View article: Artificial intelligence for diagnosis and grading of prostate cancer in biopsies: a population-based, diagnostic study
Artificial intelligence for diagnosis and grading of prostate cancer in biopsies: a population-based, diagnostic study Open
Background
An increasing volume of prostate biopsies and a worldwide shortage of urological pathologists puts a strain on pathology departments. Additionally, the high intra-observer and inter-observer variability in grading can result in…
View article: The ProtecT trial: analysis of the patient cohort, baseline risk stratification and disease progression
The ProtecT trial: analysis of the patient cohort, baseline risk stratification and disease progression Open
Objective To test the hypothesis that the baseline clinico‐pathological features of the men with localized prostate cancer (PCa) included in the ProtecT (Prostate Testing for Cancer and Treatment) trial who progressed ( n = 198) at a 10‐ye…
View article: Pathological upgrading in prostate cancer treated with surgery in the United Kingdom: trends and risk factors from the British Association of Urological Surgeons Radical Prostatectomy Registry
Pathological upgrading in prostate cancer treated with surgery in the United Kingdom: trends and risk factors from the British Association of Urological Surgeons Radical Prostatectomy Registry Open
Background Accurate grading at the time of diagnosis if fundamental to risk stratification and treatment decision making in patients with prostate cancer. Whilst previous studies have demonstrated significant pathological upgrading and dow…
View article: Gleason grading of prostate cancer: a pragmatic approach
Gleason grading of prostate cancer: a pragmatic approach Open
The Gleason grading system that was initiated by a surgeon, created by a pathologist and developed by a statistician predated serum PSA testing, systematic 18-gauge needle biopsy protocols and immunohistochemistry. It has undergone a serie…
View article: Pathologist-Level Grading of Prostate Biopsies with Artificial Intelligence
Pathologist-Level Grading of Prostate Biopsies with Artificial Intelligence Open
Background: An increasing volume of prostate biopsies and a world-wide shortage of uro-pathologists puts a strain on pathology departments. Additionally, the high intra- and inter-observer variability in grading can result in over- and und…
View article: Cancer Overdiagnosis: Pathologists in the Dock
Cancer Overdiagnosis: Pathologists in the Dock Open
To the Editor.—We read with interest Dr Schnadig's thought-provoking editorial on thyroid cancer overdiagnosis in which she questions whether "pathologists are aiding and abetting the epidemic."1 We wish to expand the discussion by highlig…
View article: Intraductal carcinoma of the prostate: a critical re-appraisal
Intraductal carcinoma of the prostate: a critical re-appraisal Open
Intraductal carcinoma of the prostate gland (IDCP), which is now categorised as a distinct entity by WHO 2016, includes two biologically distinct diseases. IDCP associated with invasive carcinoma (IDCP-inv) generally represents a growth pa…