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View article: Prognostic role of prognostic nutritional index change in patients with extensive stage small cell lung cancer treated with platinum-based chemotherapy
Prognostic role of prognostic nutritional index change in patients with extensive stage small cell lung cancer treated with platinum-based chemotherapy Open
Dynamic changes in PNI are significantly associated with prognosis in extensive-stage SCLC. Patients with low pre- and post-treatment PNI values exhibited worse outcomes, while consistently high PNI predicted better survival. This study is…
View article: Talazoparib in patients with BRCA mutant metastatic breast or ovarian carcinoma: results of early access program
Talazoparib in patients with BRCA mutant metastatic breast or ovarian carcinoma: results of early access program Open
Introduction Talazoparib is a strong PARP inhibitor with significant catalytic inhibition as well as the ability to cause PARP entrapment at DNA damage sites. It is one of the recommended treatments for individuals with BRCA-mutant advance…
View article: Prognostic Factors in Metastatic Urothelial Carcinoma Treated Without Methotrexate, Vinblastine, Doxorubicin, and Cisplatin (M-VAC): A Single-Center Retrospective Study
Prognostic Factors in Metastatic Urothelial Carcinoma Treated Without Methotrexate, Vinblastine, Doxorubicin, and Cisplatin (M-VAC): A Single-Center Retrospective Study Open
Background Bladder cancer represents the most prevalent malignancy of the urinary tract. This study aimed to develop a prognostic model for patients with metastatic urothelial carcinoma. Methodology This retrospective study included a tota…
View article: FEM and ANN modeling of stress concentration factors (K <sub>t</sub> ) of circular plates with various circular holes according to internal and external pressures
FEM and ANN modeling of stress concentration factors (K <sub>t</sub> ) of circular plates with various circular holes according to internal and external pressures Open
Stress concentration factors (SCFs) play a critical role in the structural integrity of circular plates subjected to internal and external compressive loading. This study uses Artificial Neural Networks (ANNs) and the Finite Element Method…
View article: Second Line Therapies After Tyrosine Kinase Inhibitory in Metastatic Renal Cell Carcinoma
Second Line Therapies After Tyrosine Kinase Inhibitory in Metastatic Renal Cell Carcinoma Open
Objective: Controversy exists over the choice of 2nd-line drugs after the progression of 1st-line tyrosine kinase inhibitors (TKIs) for patients unable to receive 1st-line immunotherapy. We compared the efficacy of 2nd-line treatments afte…
View article: The Role of Clinicopathological Features in Tyrosine Kinase Inhibitory Duration in EGFR Mutant Metastatic Non-Small Cell Lung Cancer
The Role of Clinicopathological Features in Tyrosine Kinase Inhibitory Duration in EGFR Mutant Metastatic Non-Small Cell Lung Cancer Open
Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective treatments for EGFR mutant (EGFRm) metastatic non-small cell lung cancer (mNSCLC). However, the benefit of EGFR-TKIs varies. We aimed to dete…
View article: Decoding Teachers' Dilemma: Unveiling the Real Obstacles to Implementing Formative Assessment in the Classroom
Decoding Teachers' Dilemma: Unveiling the Real Obstacles to Implementing Formative Assessment in the Classroom Open
This study aims to explore the barriers that prevent teachers from frequently and effectively using formative assessment approaches in classroom practices. The study employs a phenomenological design, as it seeks to reveal the current stat…
View article: Determination of Mechanical Properties of Fruit Shell Powders Reinforced Wood Plastic Composite (WPC) Materials and Case Study for I-Type Snap-Fit Model
Determination of Mechanical Properties of Fruit Shell Powders Reinforced Wood Plastic Composite (WPC) Materials and Case Study for I-Type Snap-Fit Model Open
High quality material production has been among the work of many researchers in recent years. These materials, which are obtained mostly by the production of composite materials, enable the production of lighter, more durable and less cost…
View article: Modeling of Stress Concentration Factor Using Artificial Neural Networks for a Flat Tension Bar with Opposite V-Shaped Notches
Modeling of Stress Concentration Factor Using Artificial Neural Networks for a Flat Tension Bar with Opposite V-Shaped Notches Open
Machine parts are exposed to stress accumulation due to geometric differences. Determining the stress accumulation locations is crucial to the design procedures. Studies on stress concentrations have been conducted in the past using a vari…
View article: Application of Taguchi Method for Optimization of Design Parameters in Enhancement The Robust of “C” Type Snap-fits
Application of Taguchi Method for Optimization of Design Parameters in Enhancement The Robust of “C” Type Snap-fits Open
Using statistical approaches, industrial product designs can be optimized quickly and reliably. The Taguchi method is a statistical approach that helps us to optimize the process parameters and help us to save time in terms of labor and co…
View article: End effector position calculation with the ANN for tapping machine
End effector position calculation with the ANN for tapping machine Open
Nowadays, manufacturers give importance to the production of machines that allow for faster production, reduce labor costs, and minimize operation errors to meet the increasing demand. The search for such machines leads the manufacturing s…
View article: Prognostic and predictive significance of pd-l1 expression in non-small cell lung cancer patients: a single-center experience
Prognostic and predictive significance of pd-l1 expression in non-small cell lung cancer patients: a single-center experience Open
In patients with high PD-L1 expression, the biological behavior of the cancer was more aggressive, and the life expectancy was shorter. PD-L1 expression seems to be a poor prognostic marker in NSCLC patients.
View article: The Influence of Powder Milling on Properties of SPS Compacted FeAl
The Influence of Powder Milling on Properties of SPS Compacted FeAl Open
The Fe-28 at.% Al alloy was studied in this article. The aim was to describe the influence of gas atomized powder pre-milling before SPS (Spark Plasma Sintering) sintering on the structure and properties of the bulk materials. The initial …
View article: Estimations of Stress Concentration Factors (Cw/Kts) For Helical Circular/Square Cross Sectional Tension-Compression Springs And Artificial Neural Network Modelling
Estimations of Stress Concentration Factors (Cw/Kts) For Helical Circular/Square Cross Sectional Tension-Compression Springs And Artificial Neural Network Modelling Open
Springs are used for various purposes in machine design as they can store energy under load, due to their elastic deformation characteristics. There are many types and profiles of springs. For a round wire helical compression or tension sp…
View article: Determination of Stress Concentration Factor (Kt) for a Crankshaft Under Bending Loading: An Artificial Neural Networks Approach
Determination of Stress Concentration Factor (Kt) for a Crankshaft Under Bending Loading: An Artificial Neural Networks Approach Open
Crankshafts are used in especially engines. Crankshafts are usually effected bending and torsional stress. These loading situations are important for design of engine and its parts. Crankshaft design requires design experience and engineer…
View article: Experimental research and ANN modeling on the impact of the ball burnishing process on the mechanical properties of 5083 Al-Mg material
Experimental research and ANN modeling on the impact of the ball burnishing process on the mechanical properties of 5083 Al-Mg material Open
5083 Al-Mg is the widely used material in food, chemistry, vehicle, machinery, and construction sectors, as well as in the aviation and space industries.The burnishing is normally used as the finishing operation for this material with the …
View article: Modeling of Mating / Seperating Force in Snap-Fit Joints by Artificial Neural Networks Method by Material Type and Friction Coefficient
Modeling of Mating / Seperating Force in Snap-Fit Joints by Artificial Neural Networks Method by Material Type and Friction Coefficient Open
In this study, an ArtificialNeural Network Model has been developed to calculate the mating / separatingforces of Snap-Fit joints. In order to determine the mating / separating forceof this calculation using Computer Aided Design methodolo…
View article: Mathematical Modelling And Analysis Of Cartridge Proportional Valve
Mathematical Modelling And Analysis Of Cartridge Proportional Valve Open
In this study an experimental study was conducted to investigate of open-loop responses for a proportional cartridge valve. Velocity and displacement data were acquired in reference to the sinusoidal waves at the first stage of the experim…
View article: Age-based computer-aided diagnosis approach for pancreatic cancer on endoscopic ultrasound images
Age-based computer-aided diagnosis approach for pancreatic cancer on endoscopic ultrasound images Open
It was observed that the CAD system developed in the study performed better in diagnosing pancreatic cancer images based on classification by patient age compared to diagnosis without classification. Therefore, it is imperative to take pat…