Yaşar Murat Elçin
YOU?
Author Swipe
View article: Confronting stem cells with surface-modified magnetic nanoparticles and low-frequency pulsed electromagnetic field
Confronting stem cells with surface-modified magnetic nanoparticles and low-frequency pulsed electromagnetic field Open
The combined use of Low Frequency-Pulsed Electromagnetic Field (LF-PEMF) and magnetic nanoparticles (MNPs) represents an innovative approach for biomedical applications in recent years. Also, the surface properties of MNPs play a crucial r…
View article: Current trends in the design and fabrication of PRP-based scaffolds for tissue engineering and regenerative medicine
Current trends in the design and fabrication of PRP-based scaffolds for tissue engineering and regenerative medicine Open
Blood-derived biomaterials with high platelet content have recently emerged as attractive products for tissue engineering and regenerative medicine (TERM). Platelet-derived bioactive molecules have been shown to play a role in wound healin…
View article: Magnetic biocomposite scaffold based on decellularized tendon ECM and MNP-deposited halloysite nanotubes: physicochemical, thermal, rheological, mechanical and in vitro biological evaluations
Magnetic biocomposite scaffold based on decellularized tendon ECM and MNP-deposited halloysite nanotubes: physicochemical, thermal, rheological, mechanical and in vitro biological evaluations Open
The development of new three-dimensional biomaterials with advanced versatile properties is critical to the success of tissue engineering (TE) applications. Here, (a) bioactive decellularized tendon extracellular matrix (dECM) with a sol-g…
View article: Biomimetic mineralization of platelet lysate/oxidized dextran cryogel as a macroporous 3D composite scaffold for bone repair
Biomimetic mineralization of platelet lysate/oxidized dextran cryogel as a macroporous 3D composite scaffold for bone repair Open
Scaffold development approaches using autologous sources for tissue repair are of great importance in obtaining bio-active/-compatible constructs. Platelet-rich plasma (PRP) containing various growth factors and platelet lysate (PL) derive…
View article: Decellularized Bone Matrix/45S5 Bioactive Glass Biocomposite Hydrogel‐Based Constructs with Angiogenic and Osteogenic Properties: Ex Ovo and Ex Vivo Evaluations
Decellularized Bone Matrix/45S5 Bioactive Glass Biocomposite Hydrogel‐Based Constructs with Angiogenic and Osteogenic Properties: Ex Ovo and Ex Vivo Evaluations Open
Decellularized extracellular matrix is often used to create an in vivo‐like environment that supports cell growth and proliferation, as it reflects the micro/macrostructure and molecular composition of tissues. On the other hand, bioactive…
View article: Peg-stabilized collagen-chitosan matrices: physicochemical and in vitro biological assessment of hydrogels
Peg-stabilized collagen-chitosan matrices: physicochemical and in vitro biological assessment of hydrogels Open
In this study, some of the physicochemical and in vitro biological properties of hydrogel matrices formed under different crosslinking conditions, consisting of the structural protein collagen and chitosan polysaccharide were investigated.…
View article: Evaluation of Human Osteoblasts on NIPS Micro-Patterned PCL Carriers Containing Nanohydroxyapatite and Reduced Graphene Oxide Using PSµM
Evaluation of Human Osteoblasts on NIPS Micro-Patterned PCL Carriers Containing Nanohydroxyapatite and Reduced Graphene Oxide Using PSµM Open
The content and surface topology of tissue engineering scaffolds are two important parameters in regulating the cell behavior. In this study, a phase separation micromolding (PSµM) method was implemented to develop micro-groove-imprinted p…
View article: Preliminary assessment of an injectable extracellular matrix from decellularized bovine myocardial tissue
Preliminary assessment of an injectable extracellular matrix from decellularized bovine myocardial tissue Open
The goal of this study was to develop an injectable form of decellularized bovine myocardial tissue matrix which could retain high levels of functional ECM molecules, and could gel at physiological temperature. Dissected ventricular tissue…
View article: Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface: Towards a pre-clinical model of periodontal diseases and personalized periodontal tissue engineering
Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface: Towards a pre-clinical model of periodontal diseases and personalized periodontal tissue engineering Open
While periodontal (PD) disease is among principal causes of tooth loss worldwide, regulation of concomitant soft and mineralized PD tissues, and PD pathogenesis have not been completely clarified yet. Besides, relevant pre-clinical models …
View article: GLUCOSE-OXIDASE IMMOBILIZED ON GELATIN BY VARIOUS CROSS-LINKERS
GLUCOSE-OXIDASE IMMOBILIZED ON GELATIN BY VARIOUS CROSS-LINKERS Open
Immobilization of glucose oxidase have been realized with photographic gelatin as support for chemical coupling. Chromium acetate, potassium chromium sulfate and formaldehyde were used as crosslinking agents to immobilize glucose oxidase o…
View article: Bioethical issues in genome editing by CRISPR-Cas9 technology
Bioethical issues in genome editing by CRISPR-Cas9 technology Open
Genome editing technologies have led to fundamental changes in genetic science. Among them, CRISPR-Cas9 technology particularly stands out due to its advantages such as easy handling, high accuracy, and low cost. It has made a quick introd…
View article: Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis with New Hopes?
Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis with New Hopes? Open
Mesenchymal stem cells (MSCs) bear a promising potential for regenerative medicine therapies and they repair damaged tissue through secretion of immune modulatory and anti-inflammatory molecules acting in a paracrine fashion. Coronavirus d…
View article: Encapsulation of bone marrow-MSCs in PRP-derived fibrin microbeads and preliminary evaluation in a volumetric muscle loss injury rat model: modular muscle tissue engineering
Encapsulation of bone marrow-MSCs in PRP-derived fibrin microbeads and preliminary evaluation in a volumetric muscle loss injury rat model: modular muscle tissue engineering Open
Repair of volumetric muscle loss (VML) injuries is a complicated endeavour which necessitates the collaborative use of different regenerative approaches and technologies. Herein is proposed the development of fibrin-based microbeads (FMs) …
View article: Mesenchymal Stem Cell Infusion in Haploidentical Hematopoietic Stem Cell Transplantation in Patients with Hematological Malignancies
Mesenchymal Stem Cell Infusion in Haploidentical Hematopoietic Stem Cell Transplantation in Patients with Hematological Malignancies Open
Background: Haploidentical allogeneic stem cell transplantation (HASCT) is an emerging alternative treatment method for patients without suitable donors. However, graft versus host disease (GVHD) incidence is higher in HASCT. Mesenchymal s…
View article: Clinical Applications of Injectable Biomaterials
Clinical Applications of Injectable Biomaterials Open
Regenerative medicine is an interdisciplinary field that aims to regenerate the lost or diseased tissues through the combinational use of cells, biomolecules and/or biomaterials. Injectable biomaterials have been comprehensively evaluated …
View article: Osteogenic differentiation of mesenchymal stem cells using hybrid nanofibers with different configurations and dimensionality
Osteogenic differentiation of mesenchymal stem cells using hybrid nanofibers with different configurations and dimensionality Open
Novel, hybrid fibrinogen/polylactic acid (FBG/PLA) nanofibers with different configuration (random vs aligned) and dimensionality (2‐D vs 3‐D environment) were used to control the overall behavior and the osteogenic differentiation of huma…
View article: Synthesis and characterization of thermosensitive poly(N-vinylcaprolactam)-g-collagen
Synthesis and characterization of thermosensitive poly(N-vinylcaprolactam)-g-collagen Open
In this study, we synthesized poly(N-vinylcaprolactam)-g-collagen (PNVCL-g-Col) by grafting collagen with carboxyl group-terminated thermosensitive PNVCL-COOH. The resulting biopolymer was evaluated for its structural, thermal, and rheolog…
View article: The use of autologous neurogenically-induced bone marrow-derived mesenchymal stem cells for the treatment of paraplegic dogs without nociception due to spinal trauma
The use of autologous neurogenically-induced bone marrow-derived mesenchymal stem cells for the treatment of paraplegic dogs without nociception due to spinal trauma Open
The aim of this study was to investigate the effects of percutaneous transplanted autologous neurogenically-induced bone marrow-derived mesenchymal stem cells (NIBM-MSCs) in paraplegic dogs without deep pain perception (DPP) secondary to e…
View article: Subarachnoid transplantation of autologous neurogenically induced bone marrow derived mesenchymal stem cells for the treatment of fibrocartilaginous embolic myelopathy in two dogs
Subarachnoid transplantation of autologous neurogenically induced bone marrow derived mesenchymal stem cells for the treatment of fibrocartilaginous embolic myelopathy in two dogs Open
The objective of this study was to investigate the effects of autologous neurogenically induced bone marrow-derived mesenchymal stem cells (NIBM-MSCs) in two dogs suspected to have fibrocartilaginous embolic myelopathy (FCEM). Both dogs we…
View article: Baculoviral vector loaded mesenchymal stem cells as efficient gene therapy tools for cancer treatment
Baculoviral vector loaded mesenchymal stem cells as efficient gene therapy tools for cancer treatment Open
Insufficient targeting of the therapeutic genes to tumor cells is one of the major reasons for failure in cancer gene therapy. Mesenchymal stem cells (MSCs) seem to be a good candidate as a carrier for gene therapy because of its selective…