Muriel Huss
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View article: Decline in Serum Lysophosphatidylcholine Species in Patients with Severe Inflammatory Bowel Disease
Decline in Serum Lysophosphatidylcholine Species in Patients with Severe Inflammatory Bowel Disease Open
Background/Objectives: Lysophosphatidylcholine (LPC) is composed of various lipid species, some of which exert pro-inflammatory and others anti-inflammatory activities. However, most of the LPC species analyzed to date are reduced in the s…
View article: Elevated long-to-very-long-chain ceramide ratio correlates with disease severity in inflammatory bowel disease and primary sclerosing cholangitis
Elevated long-to-very-long-chain ceramide ratio correlates with disease severity in inflammatory bowel disease and primary sclerosing cholangitis Open
View article: Fecal Arachidonic Acid: A Potential Biomarker for Inflammatory Bowel Disease Severity
Fecal Arachidonic Acid: A Potential Biomarker for Inflammatory Bowel Disease Severity Open
Arachidonic acid levels are elevated in the colonic mucosa of patients with inflammatory bowel disease (IBD). Fecal metabolites are emerging as valuable diagnostic tools for IBD. This study aimed to investigate associations between 31 feca…
View article: Cholesteryl Ester Species but Not Serum Proprotein Convertase Subtilisin/Kexin Type 9 Levels Decline in Male Patients with Active Inflammatory Bowel Disease
Cholesteryl Ester Species but Not Serum Proprotein Convertase Subtilisin/Kexin Type 9 Levels Decline in Male Patients with Active Inflammatory Bowel Disease Open
Background/Objectives: Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum cholesterol levels and inflammation, both of which are dysregulated in inflammatory bowel disease (IBD). Free cholesterol (FC) and the various typ…
View article: Interprofessional approach to personalized medication management and therapy optimization in IBD care
Interprofessional approach to personalized medication management and therapy optimization in IBD care Open
A considerable number of patients with chronic inflammatory bowel diseases (IBD) are required to manage extensive polypharmaceutical regimes, which significantly elevates the risk of drug–drug interactions. Also, the disease’s impact often…
View article: Fecal Nervonic Acid as a Biomarker for Diagnosing and Monitoring Inflammatory Bowel Disease
Fecal Nervonic Acid as a Biomarker for Diagnosing and Monitoring Inflammatory Bowel Disease Open
Background/Objectives: Inflammatory bowel disease (IBD) is a chronic immune-mediated pathology associated with the dysregulation of lipid metabolism. The administration of nervonic acid, a very long-chain fatty acid, has been shown to impr…
View article: Unique sterol metabolite shifts in inflammatory bowel disease and primary sclerosing cholangitis
Unique sterol metabolite shifts in inflammatory bowel disease and primary sclerosing cholangitis Open
Inflammatory bowel disease (IBD) triggers chronic intestinal inflammation and is linked to primary sclerosing cholangitis (PSC). Cholesterol homeostasis, tightly regulated under normal conditions, becomes disrupted in both inflammation and…
View article: Urinary Hydroxyproline as an Inflammation-Independent Biomarker of Inflammatory Bowel Disease
Urinary Hydroxyproline as an Inflammation-Independent Biomarker of Inflammatory Bowel Disease Open
Predicting responses and monitoring the severity of inflammatory bowel disease (IBD) is challenging due to a lack of specific biomarkers. This study identifies urinary hydroxyproline, a marker of collagen turnover elevated in experimental …
View article: Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis
Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis Open
Intoduction Identification of specific metabolome and lipidome profile of patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis, targeted personalized therapy, and more accurate risk stratification. Methods Nuclear ma…
View article: Urinary soluble CD163 is a putative non-invasive biomarker for primary sclerosing cholangitis
Urinary soluble CD163 is a putative non-invasive biomarker for primary sclerosing cholangitis Open
Soluble CD163 (sCD163) is a selective marker of macrophages whose circulating levels have been found to be induced in patients with active inflammatory bowel disease (IBD). Urinary proteins are emerging as non-invasive diagnostic biomarker…
View article: Serum Galectin-3 as a Non-Invasive Marker for Primary Sclerosing Cholangitis
Serum Galectin-3 as a Non-Invasive Marker for Primary Sclerosing Cholangitis Open
Primary sclerosing cholangitis (PSC) is a serious liver disease associated with inflammatory bowel disease (IBD). Galectin-3, an inflammatory and fibrotic molecule, has elevated circulating levels in patients with chronic liver disease and…
View article: P1027 Optimizing IBD Medication and Therapy: An Interdisciplinary University Outpatient Approach
P1027 Optimizing IBD Medication and Therapy: An Interdisciplinary University Outpatient Approach Open
Background A large proportion of patients with chronic inflammatory bowel disease (IBD) take a wide range of different medications, which harbor a potential risk of pharmaceutical (pharm.) interactions. Furthermore, these patients frequent…
View article: P369 Altered fecal bile acid composition in active Ulcerative Colitis
P369 Altered fecal bile acid composition in active Ulcerative Colitis Open
Background A consistent finding in inflammatory bowel disease (IBD) is an altered composition of fecal bile acids, with an increase in primary bile acids and a decrease in secondary bile acids. It is less clear, whether fecal bile acids co…
View article: Altered fecal bile acid composition in active ulcerative colitis
Altered fecal bile acid composition in active ulcerative colitis Open
View article: Fecal short chain fatty acids and urinary 3-indoxyl sulfate do not discriminate between patients with Crohn´s disease and ulcerative colitis and are not of diagnostic utility for predicting disease severity
Fecal short chain fatty acids and urinary 3-indoxyl sulfate do not discriminate between patients with Crohn´s disease and ulcerative colitis and are not of diagnostic utility for predicting disease severity Open