Muriel Vray
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View article: Intestinal microbiota diversity in children from three African countries
Intestinal microbiota diversity in children from three African countries Open
In children, the gut microbiota is a dynamic ecosystem derived from breastfeeding, oral microbiota and diet. Diversity can vary from one country to another, and the aim of this study was to compare microbiota of well-nourished children bet…
View article: Seroprevalence and molecular characterization of viral hepatitis and HIV co-infection in the Central African Republic
Seroprevalence and molecular characterization of viral hepatitis and HIV co-infection in the Central African Republic Open
Background The Central African Republic (CAR) is one of the countries with the highest prevalence of viral hepatitis infection in the world. Coinfection with HIV increases the morbidity and mortality beyond that of mono-infection with eith…
View article: Three‐arm clinical trial of improved flour targeting intestinal microbiota (MALINEA)
Three‐arm clinical trial of improved flour targeting intestinal microbiota (MALINEA) Open
The main objective of this project was to compare in the field conditions two strategies of re‐nutrition of children with moderate acute malnutrition (MAM) aged from 6 to 24 months, targeting the microbiota in comparison with a standard re…
View article: Outsciencing the scientists: a cross-sectional mixed-methods investigation of public trust in scientists in seven European countries
Outsciencing the scientists: a cross-sectional mixed-methods investigation of public trust in scientists in seven European countries Open
Background In this era of global health crises, public trust in scientists is a crucial determinant of adherence to public health recommendations. Studies of trust in scientists often link sociodemographic and other factors to such adheren…
View article: Seroprevalence and molecular characterization of viral hepatitis and HIV co-infection in the Central African Republic
Seroprevalence and molecular characterization of viral hepatitis and HIV co-infection in the Central African Republic Open
Background The Central African Republic (CAR) is one of the countries with the highest prevalence of viral hepatitis infection in the world. The present study describes the geographic distribution of viral hepatitis infections and molecula…
View article: Molecular Detection of <i>Orthohantavirus puumalaense</i> in Plasma and Urine Samples from Hospitalized Patients Presenting with a Serologically Confirmed Acute Hantavirus Infection in France
Molecular Detection of <i>Orthohantavirus puumalaense</i> in Plasma and Urine Samples from Hospitalized Patients Presenting with a Serologically Confirmed Acute Hantavirus Infection in France Open
Molecular detection of Orthohantavirus puumalaense (PUUV) RNA during the course of the disease has been studied in blood of patients in Sweden and Slovenia. The use of urine has been poorly investigated.
View article: Inappropriate antibiotic prescribing and its determinants among outpatient children in 3 low- and middle-income countries: A multicentric community-based cohort study
Inappropriate antibiotic prescribing and its determinants among outpatient children in 3 low- and middle-income countries: A multicentric community-based cohort study Open
Background Antibiotic resistance is a global public health issue, particularly in low- and middle-income countries (LMICs), where antibiotics required to treat resistant infections are not affordable. LMICs also bear a disproportionately h…
View article: Stillbirths and neonatal mortality in LMICs: A community-based mother-infant cohort study
Stillbirths and neonatal mortality in LMICs: A community-based mother-infant cohort study Open
These findings underscore the immediate need to improve care for and monitoring of children at birth and during early life to decrease infant mortality. Surveillance of stillbirth and neonatal mortality and their causes should be improved …
View article: Vaccination Coverage and Risk Factors Associated With Incomplete Vaccination Among Children in Cambodia, Madagascar, and Senegal
Vaccination Coverage and Risk Factors Associated With Incomplete Vaccination Among Children in Cambodia, Madagascar, and Senegal Open
Background Vaccination reduces mortality from infectious disease, which is the leading cause of death in children under 5 and bears a particularly high burden in low- and middle-income countries. The Global Vaccine Action Plan (2011–2020) …
View article: Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health
Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health Open
International audience
View article: Prevalence and factors associated with faecal carriage of extended-spectrum β-lactamase-producing Enterobacterales among peripartum women in the community in Cambodia
Prevalence and factors associated with faecal carriage of extended-spectrum β-lactamase-producing Enterobacterales among peripartum women in the community in Cambodia Open
Background In Southeast-Asia, where many conditions associated with dissemination of ESBL-producing Enterobacterales (ESBL-E) in the community are met, data from the community are scarce but show high ESBL-E carriage prevalence. Maternal E…
View article: Integrating Human Immunodeficiency Virus–Specific Elements in the Treatment of Tobacco Dependence (ANRS 144 Inter-ACTIV)
Integrating Human Immunodeficiency Virus–Specific Elements in the Treatment of Tobacco Dependence (ANRS 144 Inter-ACTIV) Open
International audience
View article: Excess risk of subsequent infection in hospitalized children from a community cohort study in Cambodia and Madagascar
Excess risk of subsequent infection in hospitalized children from a community cohort study in Cambodia and Madagascar Open
Background Children in low- and middle-income countries are particularly vulnerable in the months following an initial health event (IHE), with increased risk of mortality caused mostly by infectious diseases. Due to exposure to a wide ran…
View article: Bacterial vaginosis and other infections in pregnant women in Senegal
Bacterial vaginosis and other infections in pregnant women in Senegal Open
Background Bacterial vaginosis (BV) is associated with a higher risk of preterm delivery and spontaneous abortion. Yet little data on BV prevalence exist for sub-Saharan countries. The aim of this study was to estimate the prevalence of ba…
View article: Severe bacterial neonatal infections in Madagascar, Senegal, and Cambodia: A multicentric community-based cohort study
Severe bacterial neonatal infections in Madagascar, Senegal, and Cambodia: A multicentric community-based cohort study Open
Background Severe bacterial infections (SBIs) are a leading cause of neonatal deaths in low- and middle-income countries (LMICs). However, most data came from hospitals, which do not include neonates who did not seek care or were treated o…
View article: Prevalence and Factors Associated with Maternal Group B Streptococcus Colonization in Madagascar and Senegal
Prevalence and Factors Associated with Maternal Group B Streptococcus Colonization in Madagascar and Senegal Open
Maternal group B Streptococcus (GBS) colonization is a major risk factor for neonatal GBS infection. However, data on GBS are scarce in low- and middle-income countries. Using sociodemographic data and vaginal swabs collected from an inter…
View article: Cotrimoxazole versus sulfadoxine–pyrimethamine for intermittent preventive treatment of malaria in HIV‐infected pregnant women in Bangui, Central African Republic: A pragmatic randomised controlled trial
Cotrimoxazole versus sulfadoxine–pyrimethamine for intermittent preventive treatment of malaria in HIV‐infected pregnant women in Bangui, Central African Republic: A pragmatic randomised controlled trial Open
Objective The main objective of the MACOMBA (Maternity and Control of Malaria‐HIV co‐infection in Bangui) trial was to show that cotrimoxazole (CTX) is more effective than sulphadoxine–pyremethamine–IPTp (IPTp‐SP) to prevent placental mala…
View article: Conditionality of COVID-19 vaccine acceptance in European countries
Conditionality of COVID-19 vaccine acceptance in European countries Open
The COVID-19 vaccine rollout in recent months offers a powerful preventive measure that may help control SARS-CoV-2 transmission. Nevertheless, long-standing public hesitation around vaccines has heightened public health concerns that vacc…
View article: Vitamin C levels in a Central‐African mother–infant cohort: Does hypovitaminosis C increase the risk of enteric infections?
Vitamin C levels in a Central‐African mother–infant cohort: Does hypovitaminosis C increase the risk of enteric infections? Open
In the MITICA (Mother‐to‐Infant TransmIssion of microbiota in Central‐Africa) study, 48 mothers and their 50 infants were followed from delivery to 6 months between December 2017 and June 2019 in Bangui (Central‐African Republic). Blood te…
View article: Impact of Introducing Hepatitis B Birth Dose Vaccines into the Infant Immunization Program in Burkina Faso: Study Protocol for a Stepped Wedge Cluster Randomized Trial (NéoVac Study)
Impact of Introducing Hepatitis B Birth Dose Vaccines into the Infant Immunization Program in Burkina Faso: Study Protocol for a Stepped Wedge Cluster Randomized Trial (NéoVac Study) Open
To achieve global hepatitis elimination by 2030, it is critical to prevent the mother-to-child transmission (MTCT) of hepatitis B virus (HBV). Since 2009, the WHO has recommended administering hepatitis B vaccine to all neonates within 24 …
View article: Acceptability of a COVID-19 pre-exposure prophylaxis trial with hydroxychloroquine in French healthcare workers during the first wave of COVID-19 pandemic
Acceptability of a COVID-19 pre-exposure prophylaxis trial with hydroxychloroquine in French healthcare workers during the first wave of COVID-19 pandemic Open
International audience
View article: The Costs of Introducing the Hepatitis B Birth Dose Vaccine into the National Immunization Programme in Senegal (NéoVac Study)
The Costs of Introducing the Hepatitis B Birth Dose Vaccine into the National Immunization Programme in Senegal (NéoVac Study) Open
Some African countries are still reluctant to introduce the hepatitis B vaccine birth dose (HepB-BD) into their expanded program of immunization (EPI), partly because of logistical, economic, and cost information constraints. To assist dec…
View article: Bacterial Vaginosis and Risk Factors in Pregnant Women in Senegal
Bacterial Vaginosis and Risk Factors in Pregnant Women in Senegal Open
Background Bacterial vaginosis (BV) is associated with a higher risk of preterm delivery and spontaneous abortion. Yet little data on BV prevalence exist for sub-Saharan countries. The aim of this study was to estimate the prevalence of ba…
View article: Evaluating the motivation of Red Cross Health volunteers in the COVID-19 pandemic: a mixed-methods study protocol
Evaluating the motivation of Red Cross Health volunteers in the COVID-19 pandemic: a mixed-methods study protocol Open
Introduction Voluntary organisations provide essential support to vulnerable populations and front-line health responders to the COVID-19 pandemic. The French Red Cross (FRC) is prominent among organisations offering health and support ser…
View article: <i>Klebsiella pneumoniae</i> carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors
<i>Klebsiella pneumoniae</i> carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors Open
Background Klebsiella pneumoniae (hereafter, Kp) is a major public health threat responsible for high levels of multidrug resistant (MDR) human infections. Besides, Kp also causes severe infections in the community, especially in Asia and …