Murli Manohar
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View article: A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis
A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis Open
Among drug-induced adverse events, pancreatitis is life-threatening and results in substantial morbidity. A prototype example is the pancreatitis caused by asparaginase, a crucial drug used to treat acute lymphoblastic leukemia (ALL). Here…
View article: Utility of the serial portable chest x-ray for the diagnosis and quantification of COVID-19 patients
Utility of the serial portable chest x-ray for the diagnosis and quantification of COVID-19 patients Open
Peripheral consolidation and ground glass opacities were the most common chest X-ray findings in admitted COVID-19 patients. No significant difference in chest X-ray severity score was noted in the primary outcome of being discharged, prol…
View article: Radiological profile of patients undergoing Chest X-ray and computed tomography scans during COVID-19 outbreak
Radiological profile of patients undergoing Chest X-ray and computed tomography scans during COVID-19 outbreak Open
Background & Objective: Radiology has played a significant role in the diagnosis and quantifying the severity of COVID 19 pulmonary disease. This study was conducted to assess patterns and severity of COVID-19 pulmonary disease based on ra…
View article: Laryngeal lipoma: case series- successful microlaryngeal surgery
Laryngeal lipoma: case series- successful microlaryngeal surgery Open
Lipoma of the larynx is a very rare entity. In this study, we report two cases of lipoma of the larynx. The first case presented to us with hoarseness of voice and choking sensation and was diagnosed using a flexible fibreoptic video laryn…
View article: Prevalence, risk factors and clinical outcomes of COVID-19 in patients with a history of pancreatitis in Northern California
Prevalence, risk factors and clinical outcomes of COVID-19 in patients with a history of pancreatitis in Northern California Open
Objectives To evaluate the effectiveness and cost-utility of the addition of different doses of Pilates to an advice for non-specific chronic low back pain (NSCLBP) from a societal perspective. Design Randomised controlled trial with econo…
View article: Recent Review on Oxidative stress, Cellular senescence and Age-Associated Diseases
Recent Review on Oxidative stress, Cellular senescence and Age-Associated Diseases Open
Reactive Oxygen Species (ROS) is considered as the main factor of the Free Radical theory of aging over centuries and it indicates the pathophysiology of aging in mammals. ROS causes oxidative stress, which is a major component in the agin…
View article: Eosinophilic pancreatitis: a rare or unexplored disease entity?
Eosinophilic pancreatitis: a rare or unexplored disease entity? Open
Several case reports show accumulation of eosinophils in pancreatitis patients and term the disease as "eosinophilic pancreatitis (EP)". EP usually presents with a pancreatic tumour and abdominal pain in obstructive jaundice, which is gene…
View article: Agreement Between the European Organization for Research and Treatment of Cancer and Positron Emission Tomography Response Criteria in Solid Tumors in Evaluating Treatment Response in Solid Malignant Tumors
Agreement Between the European Organization for Research and Treatment of Cancer and Positron Emission Tomography Response Criteria in Solid Tumors in Evaluating Treatment Response in Solid Malignant Tumors Open
Introduction Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) is used for non-invasive staging and restaging of solid malignant tumors. PET-CT based criteria have been developed to evaluate the…
View article: STING signalling protects against chronic pancreatitis by modulating Th17 response
STING signalling protects against chronic pancreatitis by modulating Th17 response Open
Objective Chronic pancreatitis (CP) is an inflammatory disease with progressive fibrosis leading to exocrine and endocrine dysfunction. Currently, there are no approved effective therapies for CP. Stimulator of interferon genes (STING) sig…
View article: Anti-fibrotic role of IL-15 in chronic pancreatitis
Anti-fibrotic role of IL-15 in chronic pancreatitis Open
Anti-fibrotic role of IL-15 in chronic pancreatitis
View article: Synovial sarcoma masquerading as thyroglossal cyst carcinoma
Synovial sarcoma masquerading as thyroglossal cyst carcinoma Open
Synovial cell sarcoma is very rare in head and neck. It is usually seen in the extremities in close relation to the bursae and joints. In head and neck, most of the cases reported are in the retrohyoid, parapharyngeal and retropharyngeal a…
View article: IL-15 regulates fibrosis and inflammation in a mouse model of chronic pancreatitis
IL-15 regulates fibrosis and inflammation in a mouse model of chronic pancreatitis Open
Pancreatitis is an inflammatory disease characterized by the induction of several proinflammatory cytokines like interleukin (IL)-6, IL-8, IL-1β, and IL-1. Recently, the multifunctional innate cytokine IL-15 has been implicated in the prot…
View article: Immunological Responses Involved In Promoting Acute and Chronic Pancreatitis
Immunological Responses Involved In Promoting Acute and Chronic Pancreatitis Open
Pancreatitis is the inflammatory disease of pancreas induced by unusual food habit, alcohol abuse, and genetic defect in cationic trypsinogen gene.Initial occurrences are termed as acute pancreatitis and if proper consideration is not prov…
View article: Role of eosinophils in the initiation and progression of pancreatitis pathogenesis
Role of eosinophils in the initiation and progression of pancreatitis pathogenesis Open
Eosinophilic pancreatitis (EP) is reported in humans; however, the etiology and role of eosinophils in EP pathogenesis are poorly understood and not well explored. Therefore, it is interesting to examine the role of eosinophils in the init…
View article: Chronic Pancreatitis Associated Acute Respiratory Failure
Chronic Pancreatitis Associated Acute Respiratory Failure Open
Pancreatitis is a condition characterized by parenchymal inflammation of the pancreas, which is often associated with lung injury due to low level of oxygen and the condition is termed as acute pancreatitis-associated lung injury (APALI). …
View article: Pathogenic mechanisms of pancreatitis
Pathogenic mechanisms of pancreatitis Open
Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute infla…
View article: Possible Noninvasive Biomarker of Eosinophilic Esophagitis: Clinical and Experimental Evidence
Possible Noninvasive Biomarker of Eosinophilic Esophagitis: Clinical and Experimental Evidence Open
Eosinophilic esophagitis (EoE) diagnosis and follow-up response to therapy is based on repeated endoscopies and histological examination for eosinophils/HPF. The procedure is invasive and risky in particular for the pediatric population. P…
View article: Elements Involved In Promoting Eosinophilic Gastrointestinal Disorders
Elements Involved In Promoting Eosinophilic Gastrointestinal Disorders Open
Eosinophilic gastrointestinal disorders (EGID) are food allergen-induced allergic gastrointestinal disorders, characterized by accumulation of highly induced eosinophils in different segments of gastrointestinal tract along with eosinophil…