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View article: Non-contiguous Computed Tomography Lung Scans Can be Manipulated to Permit Artificial Intelligence Analyses for Interstitial Lung Disease in Systemic Sclerosis
Non-contiguous Computed Tomography Lung Scans Can be Manipulated to Permit Artificial Intelligence Analyses for Interstitial Lung Disease in Systemic Sclerosis Open
Background Artificial Intelligence can analyse high resolution CT lung scans (HRCT) in various interstitial lung diseases (ILD) including Systemic Sclerosis (SSc). Older HRCT lung scans may have been saved as small dicom file sets consisti…
View article: Severe fatigue is associated with diminished lung function and elevated Galectin-9 levels in early systemic sclerosis
Severe fatigue is associated with diminished lung function and elevated Galectin-9 levels in early systemic sclerosis Open
Introduction Symptoms resembling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) frequently affect patients with rheumatic diseases, but little is known about their frequency and disease manifestations, particularly in systemic…
View article: Limited Utility of Screening Electrocardiograms in Systemic Sclerosis: Data from the Canadian Scleroderma Research Group
Limited Utility of Screening Electrocardiograms in Systemic Sclerosis: Data from the Canadian Scleroderma Research Group Open
Objective Recommendations have been made to use electrocardiograms (EKGs) to screen for cardiac disease in systemic sclerosis (SSc). The objective of this study was to compare the prevalence of EKG abnormalities in SSc and controls to help…
View article: Treatment recommendations for the systemic pharmacological treatment of systemic sclerosis digital ulcers: Results from the World Scleroderma Foundation Ad Hoc Committee
Treatment recommendations for the systemic pharmacological treatment of systemic sclerosis digital ulcers: Results from the World Scleroderma Foundation Ad Hoc Committee Open
Introduction: Digital ulcers are an important disease manifestation of systemic sclerosis and are associated with significant morbidity. As such, there is an urgent need for the development of evidence-based recommendations to guide clinic…
View article: ‘Am I doing this right?’ Physician perceptions of the global assessment in clinical trials of systemic sclerosis
‘Am I doing this right?’ Physician perceptions of the global assessment in clinical trials of systemic sclerosis Open
Objectives Physician global assessments (PhyGAs) are commonly performed in randomized controlled trials (RCTs) in SSc. However, there is no single PhyGA applied across RCTs. We performed an exploratory qualitative study to explore percepti…
View article: Pedidos de eletrônicos como presentes de natal no evento Pelznickelplatz
Pedidos de eletrônicos como presentes de natal no evento Pelznickelplatz Open
Dentre os diversos papéis que a tecnologia exerce na sociedade, destaca-se os dispositivos eletrônicos, principalmente o seu uso por crianças e adolescentes. Visto que, adequadamente utilizado proporciona benefícios, porém, se for manusead…
View article: POS0947 ANTI-NOR-90 ANTIBODIES IN AN INTERNATIONAL COHORT OF 2140 SYSTEMIC SCLEROSIS SUBJECTS: CLINICAL ASSOCIATIONS
POS0947 ANTI-NOR-90 ANTIBODIES IN AN INTERNATIONAL COHORT OF 2140 SYSTEMIC SCLEROSIS SUBJECTS: CLINICAL ASSOCIATIONS Open
View article: Recommendations for the local management of digital ulcers in systemic sclerosis: A report from the World Scleroderma Foundation (WSF) ‘Ad hoc committee’
Recommendations for the local management of digital ulcers in systemic sclerosis: A report from the World Scleroderma Foundation (WSF) ‘Ad hoc committee’ Open
Introduction: Digital ulcers (DUs) stand out as one of the most prevalent and clinically meaningful manifestations of systemic sclerosis (SSc) and are associated with significant morbidity. While systemic (pharmacological) therapy is curre…
View article: The minimal clinically important difference of the scleroderma clinical trials consortium damage index
The minimal clinically important difference of the scleroderma clinical trials consortium damage index Open
Objective: The Scleroderma Clinical Trials Consortium Damage Index is an index of global damage in systemic sclerosis. The objective of this study is to determine the minimal clinically important difference of the Scleroderma Clinical Tria…
View article: Uso de telas por crianças durante a alimentação
Uso de telas por crianças durante a alimentação Open
Este estudo visa investigar a topografia do comportamento de uso de telas durante a alimentação, de crianças em uma praça de alimentação de loja de departamentos, em Brusque-SC, em cinco dias distintos. Os dados foram coletados por meio de…
View article: Defining Disease Activity in Systemic Sclerosis
Defining Disease Activity in Systemic Sclerosis Open
Purpose of Review Systemic sclerosis (SSc) is a multisystem autoimmune disease characterised by the presence of fibrosis, microvasculopathy and inflammation. The complex pathogenesis and widespread organ involvement have made assessment an…
View article: Usefulness of rituximab for the treatment of systemic sclerosis-associated interstitial lung disease: Further analysis of the DESIRES trial
Usefulness of rituximab for the treatment of systemic sclerosis-associated interstitial lung disease: Further analysis of the DESIRES trial Open
View article: Impacto dos papéis de gênero na escolha de brinquedos infantis: coleta de dados a partir das cartinhas escritas a são nicolau no pelznickelplatz
Impacto dos papéis de gênero na escolha de brinquedos infantis: coleta de dados a partir das cartinhas escritas a são nicolau no pelznickelplatz Open
Este estudo investiga o impacto dos papéis de gênero na escolha de brinquedos infantis, utilizando dados coletados das cartas enviadas à São Nicolau por crianças de até 11 anos no evento Pelznickelplatz, em Guabiruba, SC, nos anos de 2021 …
View article: Immunosuppressive Drugs in Early Systemic Sclerosis and Prevention of Damage Accrual
Immunosuppressive Drugs in Early Systemic Sclerosis and Prevention of Damage Accrual Open
Objective Organ damage in patients with systemic sclerosis (SSc) in individual organs such as the lungs may be prevented by receiving immunosuppressive drugs (ISs). A new measure of global organ damage, the Scleroderma Clinical Trials Cons…
View article: Brentuximab vedotin compared with historical controls for severe skin involvement in cutaneous systemic sclerosis
Brentuximab vedotin compared with historical controls for severe skin involvement in cutaneous systemic sclerosis Open
Brentuximab vedotin for scleroderma skin
View article: The burden and determinants of fatigue in incident and prevalent systemic sclerosis
The burden and determinants of fatigue in incident and prevalent systemic sclerosis Open
The burden of fatigue is substantial in both incident and prevalent SSc. Cardiopulmonary and gastrointestinal involvement are associated with worse fatigue.
View article: Investigating the trajectory of functional disability in systemic sclerosis: group-based trajectory modelling of the Health Assessment Questionnaire-Disability Index
Investigating the trajectory of functional disability in systemic sclerosis: group-based trajectory modelling of the Health Assessment Questionnaire-Disability Index Open
Two trajectories of functional disability in SSc were identified. Those with high-increasing functional disability had a distinct clinical phenotype and worse survival compared to those with low-stable functional disability. These data hig…
View article: Development and Initial Validation of the Novel Scleroderma Clinical Trials Consortium Activity Index
Development and Initial Validation of the Novel Scleroderma Clinical Trials Consortium Activity Index Open
Objective Accurate measurement of disease activity in systemic sclerosis (SSc) remains a significant clinical challenge. The Scleroderma Clinical Trials Consortium (SCTC) convened an Activity Index (AI) Working Group (WG) to develop a nove…
View article: Brentuximab vedotin for skin involvement in refractory diffuse cutaneous systemic sclerosis, an open-label trial
Brentuximab vedotin for skin involvement in refractory diffuse cutaneous systemic sclerosis, an open-label trial Open
Objective We explored the efficacy and safety of brentuximab vedotin, a chimeric anti-CD30 antibody drug conjugate, in patients with severe active diffuse cutaneous systemic sclerosis (dcSSc). Methods This phase II proof-of-concept, single…
View article: The Duty to Accommodate
The Duty to Accommodate Open
As the study by Jazayeri et al in this issue of The Journal of Rheumatology points out, the prevalence of unemployment in people with systemic sclerosis (SSc) is estimated at 40.5%, and SSc is associated with "presenteeism (ie, working whi…
View article: Non-surgical local treatments of digital ulcers in systemic sclerosis: a systematic literature review
Non-surgical local treatments of digital ulcers in systemic sclerosis: a systematic literature review Open
View article: Surgical management of digital ulcers in systemic sclerosis: A systematic literature review
Surgical management of digital ulcers in systemic sclerosis: A systematic literature review Open
View article: Systemic pharmacological treatment of digital ulcers in systemic sclerosis: a systematic literature review
Systemic pharmacological treatment of digital ulcers in systemic sclerosis: a systematic literature review Open
Objective To evaluate the evidence concerning systemic pharmacological treatments for SSc digital ulcers (DUs) to inform the development of evidence-based treatment guidelines. Methods A systematic literature review of seven databases was …
View article: POS1269 INVESTIGATING THE TRAJECTORY OF FUNCTIONAL DISABILITY IN SYSTEMIC SCLEROSIS: GROUP BASED TRAJECTORY MODELLING OF THE HEALTH ASSESSMENT QUESTIONNAIRE DISABILITY INDEX
POS1269 INVESTIGATING THE TRAJECTORY OF FUNCTIONAL DISABILITY IN SYSTEMIC SCLEROSIS: GROUP BASED TRAJECTORY MODELLING OF THE HEALTH ASSESSMENT QUESTIONNAIRE DISABILITY INDEX Open
View article: OP0235 DEVELOPMENT AND PRELIMINARY VALIDATION OF THE NOVEL SCLERODERMA CLINICAL TRIALS CONSORTIUM ACTIVITY INDEX
OP0235 DEVELOPMENT AND PRELIMINARY VALIDATION OF THE NOVEL SCLERODERMA CLINICAL TRIALS CONSORTIUM ACTIVITY INDEX Open
View article: Special Issue “Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations 2022”
Special Issue “Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations 2022” Open
This Special Issue, titled “Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations”, aims to demonstrate recent and new advances and future trends in the field of rheumatic diseases [...]
View article: Table of contents
Table of contents Open
with known cutaneous melanoma.Therefore, they should be managed according to similar strategies.
View article: Prediction of damage trajectories in systemic sclerosis using group-based trajectory modelling
Prediction of damage trajectories in systemic sclerosis using group-based trajectory modelling Open
Objectives Damage accrual in SSc can be tracked using the Scleroderma Clinical Trials Consortium Damage Index (DI). Our goal was to develop a prediction model for damage accrual in SSc patients with early disease. Methods Using patients wi…
View article: Patient and Physician Global Assessments of Disease Status in Systemic Sclerosis
Patient and Physician Global Assessments of Disease Status in Systemic Sclerosis Open
Global assessments of disease by both patients and physicians are widely used in clinical studies of systemic sclerosis (SSc). They are commonly secondary end points in randomized controlled trials (RCTs) and are considered important items…
View article: Exposure to silica and systemic sclerosis: A retrospective cohort study based on the Canadian Scleroderma Research Group
Exposure to silica and systemic sclerosis: A retrospective cohort study based on the Canadian Scleroderma Research Group Open
Introduction Systemic sclerosis (SSc) is thought to be induced by an environmental trigger in genetically predisposed individuals. This study assessed the demographic and clinical characteristics and disease severity of silica exposed SSc …