Murray Goodman
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colleagues review the current understanding of bone tissue mineralisation and structure, providing a critical outlook on the existing biomimetic strategies of mineralising collagen for bone tissue engineering applications.Featured on the c…
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Grün and Schwalbe review current experimental approaches to study the folding processes of DNA and RNA G-quadruplexes.Folding of nucleic acids with non-canonical secondary structures is an intriguing yet enigmatic process.In particular, G-…
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This special issue of Biopolymers highlights fold-switching proteins, which remodel their secondary and tertiary structures, and change their functions in response to cellular stimuli.The cover highlights six distinct fold switchers involv…
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The Pro-Gly motif is often involved in protein-protein interactions and may participate in intracellular signalling cascades.Conformationally constrained short protein-derived turn peptides thus offer promise for the development of drug ca…
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Protein aggregation into amyloid structures has been seen in numerous neurodegenerative diseases.To understand the misfolding and aggregation of these proteins, synthetic peptides are frequently studied; requiring monomeric solutions of ag…
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Side chain cross-linking is a commonly used strategy to stabilize peptides into a fixed secondary structure.Shi et al. describe all-hydrocarbon tethered chirality induced helical peptides, reporting that the absolute configuration of a pre…
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Conventional cancer therapies, e.g., surgery, chemotherapy and radiation, are not highly cancer-cell-specific, and can be harmful to healthy cells.Patwa et al. report magnetic Fe 3 O 4 silk nanodisc/poly lactic acid electrospun scaffolds a…
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This special issue showcases current peptide science research in Italy.The image is a reinterpretation of the 'Birth of Venus' (Sandro Botticelli) depicting the goddess emerging at the sea-shore as a fully-grown woman.Green helical peptide…
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OspTx2a is a new potassium channel (K V )-blocking peptide, identified from a transcriptomic and proteomic study of the sea anemone Oulactis sp.It belongs to the ShKT superfamily of peptides and proteins.Norton and co-workers report the so…