Murray Grossman
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View article: Clinicopathological characterization of vacuolar tauopathy associated with <i>VCP</i> D395G
Clinicopathological characterization of vacuolar tauopathy associated with <i>VCP</i> D395G Open
INTRODUCTION The clinical, radiological, and pathological features have not been well documented for the recently discovered autosomal‐dominant vacuolar tauopathy (VT) harboring the Valosin‐containing protein ( VCP) p.Asp395Gly variant. ME…
View article: Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing Open
Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified. We report our comprehensive genome-wide assoc…
View article: MapQA: Open-domain Geospatial Question Answering on Map Data
MapQA: Open-domain Geospatial Question Answering on Map Data Open
Geospatial question answering (QA) is a fundamental task in navigation and point of interest (POI) searches. While existing geospatial QA datasets exist, they are limited in both scale and diversity, often relying solely on textual descrip…
View article: High‐resolution 7 tesla postmortem MRI for quantitative analysis of structure‐pathology correlations in neurodegenerative diseases
High‐resolution 7 tesla postmortem MRI for quantitative analysis of structure‐pathology correlations in neurodegenerative diseases Open
Background Postmortem MRI allows brain anatomy to be examined at high‐resolution linking pathology with morphometric measurements. However, automated methods for analyzing postmortem MRI are not well developed. We present a deep learning‐b…
View article: Developing an anatomically valid segmentation protocol for anterior regions of the medial temporal lobe
Developing an anatomically valid segmentation protocol for anterior regions of the medial temporal lobe Open
Background The anterior portion of the MTL is one of the first regions targeted by pathology in sporadic Alzheimer’s disease (AD) indicating the potential for imaging metrics from this region to serve as valuable imaging biomarkers. Howeve…
View article: Clinical performance of plasma P‐tau217 for the identification of primary Alzheimer’s disease pathology or co‐pathology in sporadic frontotemporal dementia
Clinical performance of plasma P‐tau217 for the identification of primary Alzheimer’s disease pathology or co‐pathology in sporadic frontotemporal dementia Open
Background As new anti‐amyloid immunotherapies emerge for Alzheimer’s disease (AD), it is clear that early diagnosis of AD pathology is crucial for treatment success. This can be challenging in atypical presentations of AD and, together wi…
View article: Functional connectivity associations with markers of disease progression in <i>GRN</i> mutation carriers
Functional connectivity associations with markers of disease progression in <i>GRN</i> mutation carriers Open
Background Autosomal dominant progranulin ( GRN) mutations are a common genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN ‐related therapies are underway, there is an unmet need for biomarkers that can pred…
View article: High‐resolution 7 tesla postmortem MRI for quantitative analysis of structure‐pathology correlations in neurodegenerative diseases
High‐resolution 7 tesla postmortem MRI for quantitative analysis of structure‐pathology correlations in neurodegenerative diseases Open
Background Postmortem MRI allows brain anatomy to be examined at high‐resolution linking pathology with morphometric measurements. However, automated methods for analyzing postmortem MRI are not well developed. We present a deep learning‐b…
View article: Boundary-based registration improves sensitivity for detecting hypoperfusion in sporadic frontotemporal lobar degeneration
Boundary-based registration improves sensitivity for detecting hypoperfusion in sporadic frontotemporal lobar degeneration Open
Introduction Frontotemporal lobar degeneration (FTLD) is associated with FTLD due to tau (FTLD-tau) or TDP (FTLD-TDP) inclusions found at autopsy. Arterial Spin Labeling (ASL) MRI is often acquired in the same session as a structural T1-we…
View article: CSF Proteomics in Patients With Progressive Supranuclear Palsy
CSF Proteomics in Patients With Progressive Supranuclear Palsy Open
Axon guidance pathway proteins and several other molecular pathways are downregulated in PSP, compared with controls. Proteins in these pathways may be useful targets for biomarker or therapeutic development.
View article: Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing
Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing Open
Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified. We report our comprehensive genome-wide assoc…
View article: Automated deep learning segmentation of high-resolution 7 Tesla postmortem MRI for quantitative analysis of structure-pathology correlations in neurodegenerative diseases
Automated deep learning segmentation of high-resolution 7 Tesla postmortem MRI for quantitative analysis of structure-pathology correlations in neurodegenerative diseases Open
Postmortem MRI allows brain anatomy to be examined at high resolution and to link pathology measures with morphometric measurements. However, automated segmentation methods for brain mapping in postmortem MRI are not well developed, primar…
View article: MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study
MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study Open
Wellcome Trust, Rotha Abraham Trust, Brain Research UK, the Dolby Fund, Dementia Research Institute (Medical Research Council), US National Institutes of Health, and the Mayo Clinic Foundation.
View article: Automatic classification of AD pathology in FTD phenotypes using natural speech
Automatic classification of AD pathology in FTD phenotypes using natural speech Open
INTRODUCTION Screening for Alzheimer's disease neuropathologic change (ADNC) in individuals with atypical presentations is challenging but essential for clinical management. We trained automatic speech‐based classifiers to distinguish fron…
View article: Reliability and Validity of Smartphone Cognitive Testing for Frontotemporal Lobar Degeneration
Reliability and Validity of Smartphone Cognitive Testing for Frontotemporal Lobar Degeneration Open
Importance Frontotemporal lobar degeneration (FTLD) is relatively rare, behavioral and motor symptoms increase travel burden, and standard neuropsychological tests are not sensitive to early-stage disease. Remote smartphone-based cognitive…
View article: Greater white matter degeneration and lower structural connectivity in non-amnestic vs. amnestic Alzheimer’s disease
Greater white matter degeneration and lower structural connectivity in non-amnestic vs. amnestic Alzheimer’s disease Open
Introduction Multimodal evidence indicates Alzheimer’s disease (AD) is characterized by early white matter (WM) changes that precede overt cognitive impairment. WM changes have overwhelmingly been investigated in typical, amnestic mild cog…
View article: Pathologic burden goes with the flow: MRI perfusion and pathologic burden in frontotemporal lobar degeneration due to tau
Pathologic burden goes with the flow: MRI perfusion and pathologic burden in frontotemporal lobar degeneration due to tau Open
Regional cerebral blood flow (CBF) changes quantified using arterial spin labeling (ASL) are altered in neurodegenerative disorders such as frontotemporal lobar degeneration due to tau (FTLD-tau), but the relationship between ASL CBF and p…
View article: Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease
Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease Open
Objective Alzheimer's disease neuropathologic change and alpha‐synucleinopathy commonly co‐exist and contribute to the clinical heterogeneity of dementia. Here, we examined tau epitopes marking various stages of tangle maturation to test t…
View article: Changes in Digital Speech Measures in Asymptomatic Carriers of Pathogenic Variants Associated With Frontotemporal Degeneration
Changes in Digital Speech Measures in Asymptomatic Carriers of Pathogenic Variants Associated With Frontotemporal Degeneration Open
Using automatic processing pipelines, we identified early changes in the natural speech of FTD pathogenic variant carriers in the presymptomatic stage. These findings highlight the potential utility of natural speech as a digital clinical …
View article: Digital markers of motor speech impairments in spontaneous speech of patients with ALS-FTD spectrum disorders
Digital markers of motor speech impairments in spontaneous speech of patients with ALS-FTD spectrum disorders Open
Automatic vowel measures are easily derived from a brief spontaneous speech sample, are sensitive to mild-moderate stage of bulbar disease in ALS-FTSD, and may present better sensitivity to bulbar impairment compared to traditional assessm…
View article: Quantifying associations of four major proteinopathies with grey matter atrophy: an imaging‐pathology study
Quantifying associations of four major proteinopathies with grey matter atrophy: an imaging‐pathology study Open
Background Gross atrophy observed on MRI provides a clinically useful marker of possible neurodegenerative disease. However, autopsy studies of polypathology suggest atrophy is likely driven not by a single proteinopathy but also co‐pathol…
View article: Quantifying associations of four major proteinopathies with grey matter atrophy: an imaging‐pathology study
Quantifying associations of four major proteinopathies with grey matter atrophy: an imaging‐pathology study Open
Background Gross atrophy observed on MRI provides a clinically useful marker of possible neurodegenerative disease. However, autopsy studies of polypathology suggest atrophy is likely driven not by a single proteinopathy but also co‐pathol…
View article: Developing an anatomically valid segmentation protocol for early tau regions: the anterior medial temporal lobe cortices
Developing an anatomically valid segmentation protocol for early tau regions: the anterior medial temporal lobe cortices Open
Background The anterior portion of the medial temporal lobe (MTL) is one of the earliest regions showing tau deposition in Alzheimer’s disease (AD) and hence a key focus area for AD imaging biomarkers. However, the anatomical variability o…
View article: Automated lexical analysis of story recall in healthy controls
Automated lexical analysis of story recall in healthy controls Open
Background Impaired episodic memory is one of the earliest and most prominent symptoms of Alzheimer’s disease (AD). Examining how patients produce words and phrases in story recall tasks is useful for tracking and understanding progression…
View article: Evaluation of quantitative measurements of tau pathology with semi‐quantitative ratings and age
Evaluation of quantitative measurements of tau pathology with semi‐quantitative ratings and age Open
Background It is assumed quantitative digital neuropathology methods will provide more information than semi‐quantitative ratings, but this presumption lacks formal assessment. Here, we compare quantitative, whole‐slide measurements of pho…
View article: Plasma glial fibrillary acidic protein is associated with concomitant brain β‐amyloid in Lewy body disease
Plasma glial fibrillary acidic protein is associated with concomitant brain β‐amyloid in Lewy body disease Open
Background While α‐synuclein (αSyn) is the primary pathology associated with Lewy body spectrum disorders (LBSD), concomitant Alzheimer’s disease (AD) pathology is common and is predictive of clinical outcomes, including worse cognitive im…
View article: A multivariate MRI model of Alzheimer’s disease risk is associated with clinical diagnosis, PET imaging, and plasma biomarkers in a mixed dementia sample
A multivariate MRI model of Alzheimer’s disease risk is associated with clinical diagnosis, PET imaging, and plasma biomarkers in a mixed dementia sample Open
Background We sought to validate two structural MRI‐based brain health models: Spatial Pattern of Atrophy for REcognition of Alzheimer’s disease (SPARE‐AD) and SPARE‐Brain Age Gap (SPARE‐BAG), which estimates the discrepancy between biolog…
View article: Speech markers of depression dimensions across the spectrum of cognitive functions
Speech markers of depression dimensions across the spectrum of cognitive functions Open
Background Depression is a common among patients with cognitive impairment and encompass different dimensions, which may vary in their association with cognitive outcomes and biological substrates. Previous studies have shown a shift towar…