Sivakumar Murugadoss
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View article: CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials
CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials Open
The CompSafeNano project, a Research and Innovation Staff Exchange (RISE) project funded under the European Union's Horizon 2020 program, aims to advance the safety and innovation potential of nanomaterials (NMs) by integrating cutting-edg…
View article: A critical review on the toxicological and epidemiological evidence integration for assessing human health risks to environmental chemical exposures
A critical review on the toxicological and epidemiological evidence integration for assessing human health risks to environmental chemical exposures Open
Toxicology and epidemiology are the two traditional public health scientific disciplines which can contribute to investigate harmful health effects of exposure to toxic substances. Several frameworks for integrating different lines of evid…
View article: From papers to RDF-based integration of physicochemical data and adverse outcome pathways for nanomaterials
From papers to RDF-based integration of physicochemical data and adverse outcome pathways for nanomaterials Open
View article: A systematic review and meta-analysis of human population studies on the association between exposure to toxic environmental chemicals and left ventricular dysfunction (LVD)
A systematic review and meta-analysis of human population studies on the association between exposure to toxic environmental chemicals and left ventricular dysfunction (LVD) Open
Existing evidence shows that specific early markers of HF may be associated with exposure to chemical pollutants. It is recommended to include such endpoints in new longitudinal and case-control studies to confirm further risk associations…
View article: Impact of a Polymer-Based Nanoparticle with Formoterol Drug as Nanocarrier System In Vitro and in an Experimental Asthmatic Model
Impact of a Polymer-Based Nanoparticle with Formoterol Drug as Nanocarrier System In Vitro and in an Experimental Asthmatic Model Open
The implementation of nanotechnology in pulmonary delivery systems might result in better and more specific therapy. Therefore, a nano-sized drug carrier should be toxicologically inert and not induce adverse effects. We aimed to investiga…
View article: Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals
Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals Open
The adverse outcome pathway (AOP) framework plays a crucial role in the paradigm shift of toxicity testing towards the development and use of new approach methodologies. AOPs developed for chemicals are in theory applicable to nanomateria…
View article: Exploring Adverse Outcome Pathways for Nanomaterials with semantic web technologies
Exploring Adverse Outcome Pathways for Nanomaterials with semantic web technologies Open
Adverse Outcome Pathways (AOPs) have been proposed to facilitate mechanistic understanding of interactions of chemicals/materials with biological systems. Each AOP starts with a molecular initiating event (MIE) and possibly ends with adver…
View article: RDF dataset produced in the work "Exploring Adverse Outcome Pathways for Nanomaterials with semantic web technologies"
RDF dataset produced in the work "Exploring Adverse Outcome Pathways for Nanomaterials with semantic web technologies" Open
Adverse Outcome Pathways (AOPs) have been proposed to facilitate mechanistic understanding of interactions of chemicals/materials with biological systems. Each AOP starts with a molecular initiating event (MIE) and possibly ends with adver…
View article: RDF dataset produced in the work "Exploring Adverse Outcome Pathways for Nanomaterials with semantic web technologies"
RDF dataset produced in the work "Exploring Adverse Outcome Pathways for Nanomaterials with semantic web technologies" Open
Adverse Outcome Pathways (AOPs) have been proposed to facilitate mechanistic understanding of interactions of chemicals/materials with biological systems. Each AOP starts with a molecular initiating event (MIE) and possibly ends with adver…
View article: Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals_suppl2
Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals_suppl2 Open
View article: Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals_suppl1
Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals_suppl1 Open
View article: Is aggregated synthetic amorphous silica toxicologically relevant?
Is aggregated synthetic amorphous silica toxicologically relevant? Open
Background: The regulatory definition(s) of nanomaterials (NMs) frequently uses the term 'agglomerates and aggregates' (AA) despite the paucity of evidence that AA are significantly relevant from a nanotoxicological perspective. This knowl…
View article: Agglomeration State of Titanium-Dioxide (TiO2) Nanomaterials Influences the Dose Deposition and Cytotoxic Responses in Human Bronchial Epithelial Cells at the Air-Liquid Interface
Agglomeration State of Titanium-Dioxide (TiO2) Nanomaterials Influences the Dose Deposition and Cytotoxic Responses in Human Bronchial Epithelial Cells at the Air-Liquid Interface Open
Extensive production and use of nanomaterials (NMs), such as titanium dioxide (TiO2), raises concern regarding their potential adverse effects to humans. While considerable efforts have been made to assess the safety of TiO2 NMs using in v…
View article: Assessing the Toxicological Relevance of Nanomaterial Agglomerates and Aggregates Using Realistic Exposure In Vitro
Assessing the Toxicological Relevance of Nanomaterial Agglomerates and Aggregates Using Realistic Exposure In Vitro Open
Low dose repeated exposures are considered more relevant/realistic in assessing the health risks of nanomaterials (NM), as human exposure such as in workplace occurs in low doses and in a repeated manner. Thus, in a three-week study, we as…
View article: A strategy towards the generation of testable adverse outcome pathways for nanomaterials_suppl
A strategy towards the generation of testable adverse outcome pathways for nanomaterials_suppl Open
View article: A strategy towards the generation of testable adverse outcome pathways for nanomaterials
A strategy towards the generation of testable adverse outcome pathways for nanomaterials Open
Manufactured nanomaterials (NMs) are increasingly used in a wide range of industrial applications leading to a constant increase in the market size of nano-enabled products. The increased production and use of NMs are raising concerns amon…
View article: Air–Liquid Interface Exposure of Lung Epithelial Cells to Low Doses of Nanoparticles to Assess Pulmonary Adverse Effects
Air–Liquid Interface Exposure of Lung Epithelial Cells to Low Doses of Nanoparticles to Assess Pulmonary Adverse Effects Open
Reliable and predictive in vitro assays for hazard assessments of manufactured nanomaterials (MNMs) are still limited. Specifically, exposure systems which more realistically recapitulate the physiological conditions in the lung are needed…
View article: A novel TEM grid sampler for airborne particles to measure the cell culture surface dose
A novel TEM grid sampler for airborne particles to measure the cell culture surface dose Open
The applied surface dose is a key parameter for the measurement of toxic effects of airborne particles by air liquid interface exposure of human lung cells. Besides online measurement of the deposited particle mass by quartz crystal microb…
View article: Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo
Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo Open
Background The terms agglomerates and aggregates are frequently used in the regulatory definition(s) of nanomaterials (NMs) and hence attract attention in view of their potential influence on health effects. However, the influence of nanop…
View article: LiCoO2 particles used in Li-ion batteries induce primary mutagenicity in lung cells via their capacity to generate hydroxyl radicals
LiCoO2 particles used in Li-ion batteries induce primary mutagenicity in lung cells via their capacity to generate hydroxyl radicals Open
Background Li-ion batteries (LIB) are used in most portable electronics. Among a wide variety of materials, LiCoO 2 (LCO) is one of the most used for the cathode of LIB. LCO particles induce oxidative stress in mouse lungs due to their Co …
View article: Is aggregated synthetic amorphous silica toxicologically relevant?
Is aggregated synthetic amorphous silica toxicologically relevant? Open
View article: Agglomeration state of titanium-di-oxide (TiO₂) nanomaterials influences the toxicity/biological responses in human bronchial epithelial cells at the air-liquid interface
Agglomeration state of titanium-di-oxide (TiO₂) nanomaterials influences the toxicity/biological responses in human bronchial epithelial cells at the air-liquid interface Open
View article: Toxicity and biological responses (in vitro) influenced by aggregation and agglomeration of manufactured nanomaterials
Toxicity and biological responses (in vitro) influenced by aggregation and agglomeration of manufactured nanomaterials Open
View article: Toxicology of silica nanoparticles: an update
Toxicology of silica nanoparticles: an update Open
Large-scale production and use of amorphous silica nanoparticles (SiNPs) have increased the risk of human exposure to SiNPs, while their health effects remain unclear. In this review, scientific papers from 2010 to 2016 were systematically…
View article: Female versus male biological identities of nanoparticles determine the interaction with immune cells in fish
Female versus male biological identities of nanoparticles determine the interaction with immune cells in fish Open
Sex- and species-specific biological identities of nanoparticles determine cellular recognition and uptake by leukocytes in fishin vitro.