Musa Karakükçü
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View article: A Multicenter, Retrospective Study Comparing Immunosuppressive Therapy Combined with Eltrombopag to Immunosuppressive Therapy Alone as Front-Line Treatment for Pediatric Severe Aplastic Anemia
A Multicenter, Retrospective Study Comparing Immunosuppressive Therapy Combined with Eltrombopag to Immunosuppressive Therapy Alone as Front-Line Treatment for Pediatric Severe Aplastic Anemia Open
EPAG+IST induced a faster response compared to IST alone without increasing toxic effects, but EPAG did not confer additional benefits regarding OS or relapse rates in children. Notably, older age at diagnosis was significantly associated …
View article: The phenomenological examination of Turkish mothers who have hemophilic sons
The phenomenological examination of Turkish mothers who have hemophilic sons Open
Objective: Hemophilia is a coagulation disorder characterized by bleeding episodes that are genetically transmitted from mothers to sons. The disease affects the family psychologically and socially, especially the mothers, who are closely …
View article: Canpolat-Karakükcü-Dursun-Poyrazoğlu Pediatride Temel Bilgiler
Canpolat-Karakükcü-Dursun-Poyrazoğlu Pediatride Temel Bilgiler Open
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View article: Clinical and laboratory aspects of patients diagnosed with various inherited platelet disorders
Clinical and laboratory aspects of patients diagnosed with various inherited platelet disorders Open
Integrating genetic, clinical, and laboratory findings is essential in providing accurate diagnoses and management of IPDs. Early genetic diagnosis and personalized therapeutic strategies improve outcomes. Future research should focus on f…
View article: Effect of genetic mutations on outcomes of stem cell transplantation in children with hemophagocytic lymphohistiocytosis
Effect of genetic mutations on outcomes of stem cell transplantation in children with hemophagocytic lymphohistiocytosis Open
Primary hemophagocytic lymphohistiocytosis (p-HLH) can be cured with allogeneic haematopoietic stem cell transplantation (allo-HSCT). It remains unclear whether HSCT outcomes are affected by the presence of different genetic mutations. We …
View article: Successful Treatment of Childhood Hodgkin’s Lymphoma and Secondary Myelofibrosis Resistant to Intensive Therapy, Including Allogeneic Transplantation
Successful Treatment of Childhood Hodgkin’s Lymphoma and Secondary Myelofibrosis Resistant to Intensive Therapy, Including Allogeneic Transplantation Open
View article: Platelet indices: a new tool for monitoring infantile hemangioma treatment
Platelet indices: a new tool for monitoring infantile hemangioma treatment Open
Aims: Infantile hemangioma (IH) is the most common benign vascular tumor in childhood. Diagnosis, treatment decisionmaking, and monitoring of the treatment are challenging. This study aims to investigate the utilization of platelet (PLT) i…
View article: Rituximab in pediatric B-cell Non-Hodgkin Lymphoma: Clinical outcomes and prognostic implications
Rituximab in pediatric B-cell Non-Hodgkin Lymphoma: Clinical outcomes and prognostic implications Open
Objective: B-cell Non-Hodgkin Lymphoma (B-NHL) is an aggressive malignancy in children requiring prompt multidisciplinary management. This retrospective cohort study aims to evaluate the clinical characteristics, treatment outcomes, and im…
View article: Navigating Hope and Complexity: Turkish Parents' Experiences with Savior Siblings
Navigating Hope and Complexity: Turkish Parents' Experiences with Savior Siblings Open
This study highlights the complex interplay between advanced medical technologies and traditional values in Turkish society. The findings emphasize the need for comprehensive and culturally sensitive support systems and long-term follow-up…
View article: Clinical spectrum of primary hemophagocytic lymphohistiocytosis: experience of reference centers in Central and Southeast Anatolia
Clinical spectrum of primary hemophagocytic lymphohistiocytosis: experience of reference centers in Central and Southeast Anatolia Open
View article: Correction to: DIAPH1-Deficiency is Associated with Major T, NK and ILC Defects in Humans
Correction to: DIAPH1-Deficiency is Associated with Major T, NK and ILC Defects in Humans Open
View article: DIAPH1-Deficiency is Associated with Major T, NK and ILC Defects in Humans
DIAPH1-Deficiency is Associated with Major T, NK and ILC Defects in Humans Open
View article: 30 Years of Wilms Tumor Experience at One Center in Türkiye’s Central Anatolia Region
30 Years of Wilms Tumor Experience at One Center in Türkiye’s Central Anatolia Region Open
Objective: The current study aims to evaluate the clinical presentation, treatment, and follow-up of children with Wilms Tumor (WT) who had been admitted to Erciyes University, Faculty of Medicine Department of Pediatric Hematology and Onc…
View article: CHANGES IN MUCOSA-ASSOCIATED INVARIANT T CELLS (MAIT), ASSOCIATED CYTOKINES, AND MR-1+ CELL NUMBER AND PHENOTYPE IN THE PERIPHERAL BLOOD OF PEDIATRIC ITP PATIENTS WITH AND WITHOUT ELTROMBOPAG THERAPY
CHANGES IN MUCOSA-ASSOCIATED INVARIANT T CELLS (MAIT), ASSOCIATED CYTOKINES, AND MR-1+ CELL NUMBER AND PHENOTYPE IN THE PERIPHERAL BLOOD OF PEDIATRIC ITP PATIENTS WITH AND WITHOUT ELTROMBOPAG THERAPY Open
Objective: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia caused by the formation of antibodies against platelets. Mucosa-associated invariant T cells (MAIT), a subset of unconventional T cells pre…
View article: The influence of RANKL/osteoprotegerin on the prognosis of childhood acute lymphoblastic leukemia
The influence of RANKL/osteoprotegerin on the prognosis of childhood acute lymphoblastic leukemia Open
Aims: The aim is to investigate the association of the osteoprotegerin (OPG)/ soluble(s) receptor activator nuclear kappa B ligand (RANKL) with the prognosis of children with acute lymphoblastic leukemia (ALL). Methods: Patients with the d…
View article: COVID-19 disease in children and adolescents following hematopoietic stem cell transplantation: A report from the Turkish Pediatric Bone Marrow Transplantation Study Group
COVID-19 disease in children and adolescents following hematopoietic stem cell transplantation: A report from the Turkish Pediatric Bone Marrow Transplantation Study Group Open
Background: Data on the outcome and risk factors of pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. Objectives: We aimed to describe risk factors for a severe co…
View article: The Resilience Scale for Parents of Children with Cancer: Scale development and psychometric evaluation
The Resilience Scale for Parents of Children with Cancer: Scale development and psychometric evaluation Open
Objective This study aimed to develop a Resilience Scale for Parents of Children with Cancer (RSP‐CC) designed specifically for parents of children with cancer and to evaluate its psychometric properties. Methods Based on the Resilience Mo…
View article: Determination of Genotypes in Cytomegalovirus (CMV) Strains Obtained from Pediatric and Adult Immunocompromised Patients
Determination of Genotypes in Cytomegalovirus (CMV) Strains Obtained from Pediatric and Adult Immunocompromised Patients Open
Background and Purpose: Cytomegalovirus causes asymptomatic disease in individuals with normal immune system; and leads to serious complications in immunocompromised individuals and fetus. In CMV, gB is the most studied glycoprotein in ter…
View article: Intracranial hemorrhage in children with hemophilia
Intracranial hemorrhage in children with hemophilia Open
Aim: Hemophilias are inherited bleeding disorders, in which the patients generally present with clinical complaints of hemarthrosis. Intracranial hemorrhage (ICH) is one of the severe bleeding types with the highest mortality and morbidity…
View article: Etiological Factors of Opsoclonus Myoclonus Ataxia Syndrome: A Single Center Experience with Eight Children
Etiological Factors of Opsoclonus Myoclonus Ataxia Syndrome: A Single Center Experience with Eight Children Open
Objective: Opsoclonus myoclonus ataxia syndrome (OMAS) is a rare neurological disorder characterized by acute/subacute onset multi-directional chaotic eye movements, accompanied by myoclonus and cerebellar ataxia; as well as sleep disturba…
View article: Protocol for cell surface biotinylation of magnetic labeled and captured human peripheral blood mononuclear cells
Protocol for cell surface biotinylation of magnetic labeled and captured human peripheral blood mononuclear cells Open
View article: A pilot study for treatment of severe COVID-19 pneumonia by aerosolized formulation of convalescent human immune plasma exosomes (ChipEXO™)
A pilot study for treatment of severe COVID-19 pneumonia by aerosolized formulation of convalescent human immune plasma exosomes (ChipEXO™) Open
This is a single-center prospective, open-label, single arm interventional study to test the safety and efficacy of recently described ChipEXO™ for severe COVID-19 pneumonia. The ChipEXO™ is a natural product derived from convalescent huma…
View article: Antibody Response against Vaccine Antigens in Children after TCRαβ-Depleted Haploidentical Stem Cell Transplantation: Is It Similar to That in Recipients with Fully Matched Donors?
Antibody Response against Vaccine Antigens in Children after TCRαβ-Depleted Haploidentical Stem Cell Transplantation: Is It Similar to That in Recipients with Fully Matched Donors? Open
Recipients of hematopoietic stem cell transplantation (HSCT) with HLA-mismatched donors are more immune suppressed than those with fully matched donors. The immunologic response to vaccines also may differ in HLA-mismatched haploidentical …
View article: Hypomorphic RAG deficiency: impact of disease burden on survival and thymic recovery argues for early diagnosis and HSCT
Hypomorphic RAG deficiency: impact of disease burden on survival and thymic recovery argues for early diagnosis and HSCT Open
Patients with hypomorphic mutations in the RAG1 or RAG2 gene present with either Omenn syndrome or atypical combined immunodeficiency with a wide phenotypic range. Hematopoietic stem cell transplantation (HSCT) is potentially curative, but…
View article: The Effectiveness of Mesenchymal Stem Cell Therapy on COVID-19 Patients at Intensive Care Unit: Case Control Study
The Effectiveness of Mesenchymal Stem Cell Therapy on COVID-19 Patients at Intensive Care Unit: Case Control Study Open
Our study presents the largest case series in the literature, and it was observed that MSC treatment may not significantly affect overall survival or comorbid disease-based survival, in contrast to many other studies in the literature.
View article: Triosephosphate isomerase deficiency in an infant
Triosephosphate isomerase deficiency in an infant Open
Triosephosphate isomerase deficiency is an autosomal recessive disorder characterized by progressive neuromuscular degeneration, seizure, dystonia, weak muscles, cardiomyopathy, hemolytic anemia, and death in early childhood. In the glycol…
View article: The Significance of soluble CD40 and CD40 ligand levels in childhood acute lymphoblastic leukemia patients
The Significance of soluble CD40 and CD40 ligand levels in childhood acute lymphoblastic leukemia patients Open
Background and aim: Acute lymphoblastic leukemia (ALL) is the most prevalent malignant disorder in childhood. CD40 is a member of the tumor necrosis factor (TNF) receptor family. Soluble CD40 (sCD40) was previously found to be associated w…
View article: A Novel Loss of Function Variant of SLC19A1 Presented with Immunodeficiency and Benefited from Folinic Acid Treatment
A Novel Loss of Function Variant of SLC19A1 Presented with Immunodeficiency and Benefited from Folinic Acid Treatment Open
Insufficient dietary folate intake, hereditary malabsorption, or defects in folate metabolism may lead to combined immunodeficiency (CID). Although loss of function mutations in the major intestinal folate transporter PCFT/SLC46A1 was show…
View article: A Novel Loss of Function Variant of SLC19A1 Presented with Immunodeficiency and Benefited from Folinic Acid Treatment
A Novel Loss of Function Variant of SLC19A1 Presented with Immunodeficiency and Benefited from Folinic Acid Treatment Open
Insufficient dietary folate intake, hereditary malabsorption, or defects in folate metabolism may lead to combined immunodeficiency (CID). Although loss of function mutations in the major intestinal folate transporter PCFT/SLC46A1 was show…
View article: The Effect of Mesenchymal Stromal Cells on the Mortality of Patients with Sepsis and Septic Shock: A Promising Therapy
The Effect of Mesenchymal Stromal Cells on the Mortality of Patients with Sepsis and Septic Shock: A Promising Therapy Open
Purpose. Sepsis and septic shock are the major causes of death in intensive care units. This study aimed to evaluate the clinical safety and efficacy of mesenchymal stem cells (MSCs) in sepsis and septic shock patients. Methods. Ten patien…