Mustafa Güzel
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View article: Author Correction: A roadmap for equitable reuse of public microbiome data
Author Correction: A roadmap for equitable reuse of public microbiome data Open
View article: A roadmap for equitable reuse of public microbiome data
A roadmap for equitable reuse of public microbiome data Open
View article: A cost and community perspective on the barriers to microbiome data reuse
A cost and community perspective on the barriers to microbiome data reuse Open
Microbiome research is becoming a mature field with a wealth of data amassed from diverse ecosystems, yet the ability to fully leverage multi-omics data for reuse remains challenging. To provide a view into researchers’ behavior and attitu…
View article: Investigation the selective anticancer activities of montmorillonite and curcumin on the pancreatic and breast cancer
Investigation the selective anticancer activities of montmorillonite and curcumin on the pancreatic and breast cancer Open
View article: An arsenal of naturopathic compounds for the treatment of COVID-19: A comprehensive review
An arsenal of naturopathic compounds for the treatment of COVID-19: A comprehensive review Open
Despite the tremendous efforts to find a reasonable potent and efficacious drug candidate for the treatment of COVID-19, there is not a magic drug to cure the symptoms of this deadly disease.This study aims to give some information about n…
View article: Deep Learning for Image-Based Detection of Weeds from Emergence to Maturity in Wheat Fields
Deep Learning for Image-Based Detection of Weeds from Emergence to Maturity in Wheat Fields Open
View article: TW68, Cryptochromes stabilizer, regulates fasting blood glucose level in<i>ob/ob</i>and fat-induced diabetic mice
TW68, Cryptochromes stabilizer, regulates fasting blood glucose level in<i>ob/ob</i>and fat-induced diabetic mice Open
Cryptochromes (CRYs), transcriptional repressors of the circadian clock in mammals, inhibit cAMP production when glucagon activates G-protein coupled receptors. Therefore, molecules that modulate CRYs have the potential to regulate glucone…
View article: Invited Speaker Abstracts
Invited Speaker Abstracts Open
There is an intricate interplay of protein structure-function relationships in the pathogenesis of ne diseases, especially in Ankylosing Spondylitis (AS). the Major Histocompatibility Complex I allele, HLA-B*27, and Endoplasmic Reticulum A…
View article: Deep Learning for Image-Based Detection of Weeds from Emergence to Maturity in Wheat Fields
Deep Learning for Image-Based Detection of Weeds from Emergence to Maturity in Wheat Fields Open
View article: An economical and practical procedure of favipiravir synthesis for the treatment of Covid-19
An economical and practical procedure of favipiravir synthesis for the treatment of Covid-19 Open
View article: Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice
Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice Open
View article: Cytotoxic Activity and Docking Studies of 2-arenoxybenzaldehyde N-acyl Hydrazone and 1,3,4-Oxadiazole Derivatives against Various Cancer Cell Lines
Cytotoxic Activity and Docking Studies of 2-arenoxybenzaldehyde N-acyl Hydrazone and 1,3,4-Oxadiazole Derivatives against Various Cancer Cell Lines Open
To understand whether previously synthesized novel hydrazone and oxadiazole derivatives have promising anticancer effects, docking studies and in vitro toxicity assays were performed on A-549, MDA-MB-231, and PC-3 cell lines. The antiproli…
View article: Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase
Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase Open
Farnesyltransferase (FTase) is a heterodimeric enzyme, which catalyzes covalent attachment of the farnesyl group to target proteins, thus coordinating their trafficking in the cell. FTase has been demonstrated to be highly expressed in can…
View article: Potential of Novel Methyl Jasmonate Analogs as Anticancer Agents to Metabolically Target HK-2 Activity in Glioblastoma Cells
Potential of Novel Methyl Jasmonate Analogs as Anticancer Agents to Metabolically Target HK-2 Activity in Glioblastoma Cells Open
Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, hexokinase-II (…
View article: CCDC 2126030: Experimental Crystal Structure Determination
CCDC 2126030: Experimental Crystal Structure Determination Open
View article: Antileishmanial Activity of BNIPDaoct- and BNIPDanon-loaded Emulsomes on Leishmania infantum Parasites
Antileishmanial Activity of BNIPDaoct- and BNIPDanon-loaded Emulsomes on Leishmania infantum Parasites Open
Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on macrophages plus …
View article: The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies
The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies Open
View article: Instant determination of the artemisinin from various <i>Artemisia annua L</i>. extracts by LC‐ESI‐MS/MS and their <i>in‐silico</i> modelling and <i>in vitro</i> antiviral activity studies against SARS‐CoV‐2
Instant determination of the artemisinin from various <i>Artemisia annua L</i>. extracts by LC‐ESI‐MS/MS and their <i>in‐silico</i> modelling and <i>in vitro</i> antiviral activity studies against SARS‐CoV‐2 Open
Introduction Numerous efforts in natural product drug development are reported for the treatment of Coronavirus. Based on the literature, among these natural plants Artemisia annua L . shows some promise for the treatment of SARS‐CoV‐2. Ob…
View article: Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice
Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice Open
Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous level of the CRY1 in mammals will affect circadian rhythm and the relation of such a decrease wit…
View article: The neutralization effect of Montelukast on SARS-CoV-2 is shown by multiscale<i>in silico</i>simulations and combined<i>in vitro</i>studies
The neutralization effect of Montelukast on SARS-CoV-2 is shown by multiscale<i>in silico</i>simulations and combined<i>in vitro</i>studies Open
Small molecule inhibitors have previously been investigated in different studies as possible therapeutics in the treatment of SARS-CoV-2. In the current drug repurposing study, we identified the leukotriene (D4) receptor antagonist Montelu…
View article: Novel Synthetic Approaches for Bisnaphthalimidopropyl (BNIP) Derivatives as Potential Anti-Parasitic Agents for the Treatment of Leishmaniasis
Novel Synthetic Approaches for Bisnaphthalimidopropyl (BNIP) Derivatives as Potential Anti-Parasitic Agents for the Treatment of Leishmaniasis Open
Leishmaniasis is a neglected parasitic disease that is widely seen in more than 60 countries worldwide, including Turkey and its subcontinental region. There are several chemotherapy agents for the treatment of leishmaniasis, including pen…
View article: Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20
Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 Open
View article: Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model Open
View article: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20
The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 Open
View article: PO-412 Novel drug discovery approaches for cancer with the inspiration of a natural product – methyl jasmonate
PO-412 Novel drug discovery approaches for cancer with the inspiration of a natural product – methyl jasmonate Open
Introduction Cancer is one of the well-known illnesses leading to death. Clinical validations prove that protein kinases are an attractive class of therapeutic drug targets for cancer as demonstrated with the recent approval of six protei…
View article: İstanbul Çeşidi Vişnenin (Prunus cerasus L.) Fiziko-Mekanik Özellikleri İle Renk Değerlerinin Belirlenmesi
İstanbul Çeşidi Vişnenin (Prunus cerasus L.) Fiziko-Mekanik Özellikleri İle Renk Değerlerinin Belirlenmesi Open
Tarımsal ürünlerin hasat, temizleme, sınıflandırma ve depolama işlemlerinde kullanılacak makine-ekipmanların tasarlanmasında ve ürünlerin hasat olgunluğu, kalite farklılığı gibi parametrelerin belirlenmesinde kullanılan en önemli kriter; ü…
View article: The Role of Importance of Medicinal Chemistry in Novel Drug Discovery and Development: Review
The Role of Importance of Medicinal Chemistry in Novel Drug Discovery and Development: Review Open
Medisinal kimya, yeni ilaç moleküllerinin keşfi ve geliştirilmesi sürecinde en önemli rollerden birini oluşturmaktadır. İlaç metabolizması ve toksikolojisiyle doğrudan ilgilenmesi, test sonuçlarını değerlendirerek kararlar alabilmesi ve bu…
View article: Investigation of three different methods for detection of ESBL production and antibiotic resistance percentage of ESBL producing Gram negative bacteria
Investigation of three different methods for detection of ESBL production and antibiotic resistance percentage of ESBL producing Gram negative bacteria Open
Objective: In this study, it was aimed to evaluate the efficacy of chromogenic agar for rapid and accurate identification of bacteria producing extended spectrum beta-lactamase (ESBL) and to investigate the antibiotic resistance rates of 1…