Mustafa Raoof
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View article: Distinct clinicopathological and survival profiles of CLDN18.2 and PD-L1 expression in advanced gastric cancer and gastroesophageal junction adenocarcinoma
Distinct clinicopathological and survival profiles of CLDN18.2 and PD-L1 expression in advanced gastric cancer and gastroesophageal junction adenocarcinoma Open
View article: Safety and Efficacy of Cisplatin and Doxorubicin Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Patients with Ovarian Cancer with Peritoneal Metastases: A Multicenter US Phase I Trial
Safety and Efficacy of Cisplatin and Doxorubicin Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Patients with Ovarian Cancer with Peritoneal Metastases: A Multicenter US Phase I Trial Open
Background Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a novel, minimally invasive method of delivering intraperitoneal chemotherapy with promising peritoneal disease control in ovarian cancer. Methods This US multicent…
View article: Predicting Severe Postoperative Complications after CRS‐HIPEC: An Externally Validated Machine‐Learning Tool
Predicting Severe Postoperative Complications after CRS‐HIPEC: An Externally Validated Machine‐Learning Tool Open
Introduction Current decision support tools designed to predict postoperative complications, following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC), are limited by small sample sizes and lack of external…
View article: Management of Peritoneal Metastasis in Patients with Pancreatic Ductal Adenocarcinoma
Management of Peritoneal Metastasis in Patients with Pancreatic Ductal Adenocarcinoma Open
The peritoneum is the second most common site of metastasis in patients with pancreatic ductal adenocarcinoma (PDAC). Up to half of all patients that undergo curative-intent resection eventually develop peritoneal metastasis (PM), which ac…
View article: Long term outcomes associated with the use of perioperative systemic chemotherapy on low grade appendiceal mucinous neoplasms with pseudomyxoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Long term outcomes associated with the use of perioperative systemic chemotherapy on low grade appendiceal mucinous neoplasms with pseudomyxoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy Open
Introduction Low grade appendiceal mucinous neoplasms (LAMN) are indolent tumors that lack invasive potential but may present as pseudomyxoma peritonei. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) sign…
View article: Using artificial intelligence and statistics for managing peritoneal metastases from gastrointestinal cancers
Using artificial intelligence and statistics for managing peritoneal metastases from gastrointestinal cancers Open
Objective The primary objective of this study is to investigate various applications of artificial intelligence (AI) and statistical methodologies for analyzing and managing peritoneal metastases (PM) caused by gastrointestinal cancers. Me…
View article: Circulating Tumor DNA Testing in Curatively Resected Colorectal Cancer and Salvage Resection
Circulating Tumor DNA Testing in Curatively Resected Colorectal Cancer and Salvage Resection Open
Importance Serial circulating tumor DNA (ctDNA) has emerged as a routine surveillance strategy for patients with resected colorectal cancer, but how serial ctDNA monitoring is associated with potential curative outcomes has not been formal…
View article: ASO Author Reflections: Impact of PIPAC-Oxaliplatin on Functional Recovery, Quality of Life, Good Days, and Survival in Refractory Colorectal and Appendiceal Carcinomatosis
ASO Author Reflections: Impact of PIPAC-Oxaliplatin on Functional Recovery, Quality of Life, Good Days, and Survival in Refractory Colorectal and Appendiceal Carcinomatosis Open
View article: Liver Resection With Extrahepatic Disease: A Population‐Based Analysis of Thoughtful Selection
Liver Resection With Extrahepatic Disease: A Population‐Based Analysis of Thoughtful Selection Open
Background The oncologic benefit of liver resection for colorectal liver metastases (CRLM) in the setting of concurrent extrahepatic disease (EHD) is controversial. We performed a population‐based, cross‐sectional study to determine the pr…
View article: Base-excision repair pathway regulates transcription-replication conflicts in pancreatic ductal adenocarcinoma
Base-excision repair pathway regulates transcription-replication conflicts in pancreatic ductal adenocarcinoma Open
Oncogenic mutations (such as in KRAS) can dysregulate transcription and replication, leading to transcription-replication conflicts (TRCs). Here, we demonstrate that TRCs are enriched in human pancreatic ductal adenocarcinoma (PDAC) compar…
View article: Impact of PIPAC-Oxaliplatin on Functional Recovery, Good Days, and Survival in a Refractory Colorectal and Appendiceal Carcinomatosis: Secondary Analysis of the US PIPAC Collaborative Phase 1 Trial
Impact of PIPAC-Oxaliplatin on Functional Recovery, Good Days, and Survival in a Refractory Colorectal and Appendiceal Carcinomatosis: Secondary Analysis of the US PIPAC Collaborative Phase 1 Trial Open
Background Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a novel, minimally invasive, safe, and repeatable method to treat carcinomatosis. Evidence regarding the clinical benefit (quality of life and survival) of PIPAC co…
View article: Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) experience in patients with recurrent low grade serous ovarian carcinoma (LGSOC): sub-cohort report of phase 1 clinical trial
Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) experience in patients with recurrent low grade serous ovarian carcinoma (LGSOC): sub-cohort report of phase 1 clinical trial Open
Introduction Low grade serous ovarian carcinoma (LGSOC) is a rare subtype of ovarian cancer (OC) that is challenging to treat due to its relative chemoresistance. Given that LGSOC patients often recur in the peritoneal cavity, novel intrap…
View article: Emerging therapeutic approaches for peritoneal metastases from gastrointestinal cancers
Emerging therapeutic approaches for peritoneal metastases from gastrointestinal cancers Open
View article: Therapeutic Targeting of Oncogene-induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma
Therapeutic Targeting of Oncogene-induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma Open
Purpose Transcription-replication conflicts (TRCs) are a major source of endogenous replication stress in cancer. We previously discovered that pancreatic ductal adenocarcinoma (PDAC) demonstrates uniquely high levels of TRCs compared to o…
View article: Base Excision Repair Pathway Regulates Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma
Base Excision Repair Pathway Regulates Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma Open
Oncogenic mutations (such as in KRAS) can dysregulate transcription and replication leading to transcription conflicts (TRCs). Unresolved TRCs can cause lethal DNA damage. Here, we sought to investigate the oncogene dependency of TRCs and …
View article: Integrated characterization of cell types, states and molecular programs in disseminated appendiceal neoplasms
Integrated characterization of cell types, states and molecular programs in disseminated appendiceal neoplasms Open
Appendiceal neoplasms include a heterogeneous group of epithelial and non-epithelial tumors with varying malignant potential. Despite the rise in incidence of appendiceal neoplasms in recent years, limited progress has been made in the und…
View article: Randomized Controlled Trial of Perioperative Telemonitoring of Patient Generated Health Data in Gastrointestinal Oncologic Surgery: Assessing Overall Feasibility and Acceptability
Randomized Controlled Trial of Perioperative Telemonitoring of Patient Generated Health Data in Gastrointestinal Oncologic Surgery: Assessing Overall Feasibility and Acceptability Open
View article: Impact of Sodium Thiosulfate on Prevention of Nephrotoxicities in HIPEC: An Ancillary Evaluation of Cisplatin-Induced Toxicities in Ovarian Cancer
Impact of Sodium Thiosulfate on Prevention of Nephrotoxicities in HIPEC: An Ancillary Evaluation of Cisplatin-Induced Toxicities in Ovarian Cancer Open
View article: Prediction of Early Recurrence Following CRS/HIPEC in Patients With Disseminated Appendiceal Cancer
Prediction of Early Recurrence Following CRS/HIPEC in Patients With Disseminated Appendiceal Cancer Open
View article: Neighborhood-Level Socioeconomic Disadvantage Predicts Outcomes in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Malignancy
Neighborhood-Level Socioeconomic Disadvantage Predicts Outcomes in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Malignancy Open
View article: ASO Author Reflections: PIPAC Oxaliplatin in Refractory Colorectal or Appendiceal Carcinomatosis: Encouraging Results from a Phase 1 Clinical Trial
ASO Author Reflections: PIPAC Oxaliplatin in Refractory Colorectal or Appendiceal Carcinomatosis: Encouraging Results from a Phase 1 Clinical Trial Open
View article: Safety and Efficacy of Oxaliplatin Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Colorectal and Appendiceal Cancer with Peritoneal Metastases: Results of a Multicenter Phase I Trial in the USA
Safety and Efficacy of Oxaliplatin Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Colorectal and Appendiceal Cancer with Peritoneal Metastases: Results of a Multicenter Phase I Trial in the USA Open
View article: Complete Pathologic Response to PARP Inhibitor Olaparib in a Patient with Stage IVB Recurrent Endometrioid Endometrial Adenocarcinoma
Complete Pathologic Response to PARP Inhibitor Olaparib in a Patient with Stage IVB Recurrent Endometrioid Endometrial Adenocarcinoma Open
Treatment for endometrial cancer is rapidly evolving with the increased use and integration of somatic tumor RNA sequencing in clinical practice. There is a paucity of data regarding PARP inhibition in endometrial cancer given that mutatio…
View article: Evaluating End Points of the Efficacy of Intraperitoneal Chemotherapy Techniques Including PIPAC
Evaluating End Points of the Efficacy of Intraperitoneal Chemotherapy Techniques Including PIPAC Open
View article: Base Excision Repair Pathway Regulates Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma
Base Excision Repair Pathway Regulates Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma Open
View article: Importance of magnetic resonance imaging and positron emission tomography as preoperative staging tests prior to liver resection
Importance of magnetic resonance imaging and positron emission tomography as preoperative staging tests prior to liver resection Open
View article: EP334/#194 Single cell transcriptomic analysis of a low grade serous ovarian cancer patient treated with pressurized intraperitoneal aerosolized chemotherapy (PIPAC)
EP334/#194 Single cell transcriptomic analysis of a low grade serous ovarian cancer patient treated with pressurized intraperitoneal aerosolized chemotherapy (PIPAC) Open
Objectives Low grade serous (LGS) ovarian cancer (OC) patients with recurrent peritoneal metastases (PM) have poor prognoses due to inherently chemo-resistant tumors. PIPAC is an intraperitoneal (IP) treatment that intensifies chemotherapy…
View article: Advances in Radiation Oncology for Pancreatic Cancer: An Updated Review
Advances in Radiation Oncology for Pancreatic Cancer: An Updated Review Open
This review aims to summarize the recent advances in radiation oncology for pancreatic cancer. A systematic search of the MEDLINE/PubMed database and Clinicaltrials.gov was performed, focusing on studies published within the last 10 years.…
View article: Feasibility of perioperative remote monitoring of patient‐generated health data in complex surgical oncology
Feasibility of perioperative remote monitoring of patient‐generated health data in complex surgical oncology Open
Background The feasibility of remote perioperative telemonitoring of patient‐generated physiologic health data and patient‐reported outcomes in a high risk complex general and urologic oncology surgery population is evaluated. Methods Comp…
View article: Immunotherapy-Based Neoadjuvant Treatment of Advanced Microsatellite Instability–High Gastric Cancer: A Case Series
Immunotherapy-Based Neoadjuvant Treatment of Advanced Microsatellite Instability–High Gastric Cancer: A Case Series Open
Despite the use of first-line therapies like fluoropyrimidine and platinum-based cytotoxic chemotherapy, gastric cancer (GC) continues to carry a poor prognosis. Recent subgroup analyses of first-line phase III trials have demonstrated tha…