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View article: Antiproliferative Activity and Apoptotic Mechanisms of β-Sitosterol and Its Derivatives as Anti-Breast Cancer Agents: In Silico and In Vitro
Antiproliferative Activity and Apoptotic Mechanisms of β-Sitosterol and Its Derivatives as Anti-Breast Cancer Agents: In Silico and In Vitro Open
Based on the results, β-sitosterol and its derivatives, particularly 3β-glucose sitosterol, show as the most promising potential adjuvant therapy for hormone-positive breast cancer.
View article: The Suppression of Signal Transducer and Activator of Transcription-3 in A549 human Lung Carcinoma Cells Induced by Marine Sponge Callyspongia aerizusa
The Suppression of Signal Transducer and Activator of Transcription-3 in A549 human Lung Carcinoma Cells Induced by Marine Sponge Callyspongia aerizusa Open
In conclusion, the ergosteroids present in marine sponge C. aerizusa extract signified a remarkable reduction in malignancy, migration, and invasion capabilities in A549 lung carcinoma cells. These results suggested their promising candida…
View article: The Health Profile of Students and Teachers in Madrasah Al Ihsan, Kecamatan Ciparay, Kabupaten Bandung
The Health Profile of Students and Teachers in Madrasah Al Ihsan, Kecamatan Ciparay, Kabupaten Bandung Open
The prevalence of diabetes mellitus and hypertension in Indonesia is increasing both in low- and high-income communities. Therefore, health awareness should be started from a younger age for the prospective future generation. This study, i…
View article: Chromatogram profile of andrographolide-glucuronate and andrographolide glycine in rabbit feces extract
Chromatogram profile of andrographolide-glucuronate and andrographolide glycine in rabbit feces extract Open
Pharmacokinetic studies of plant extract have been carried out worldwide.Our previous pharmacokinetic study of andrographolide, a major diterpenoid of Andrographis paniculata leaves given orally in inflammation-induced New Zealand rabbits,…
View article: Wanita Sebagai Pondasi Peradaban Perspektif Hadis
Wanita Sebagai Pondasi Peradaban Perspektif Hadis Open
Women have played a significant role in the history of human civilization, including Islamic civilization. Muslim women such as Khadijah, Aisha, and other female companions (shahabiyah) have made substantial contributions in various fields…
View article: Molecular Docking Simulation of Phenolics towards Tyrosinase, Phenolic Content, and Radical Scavenging Activity of Some Zingiberaceae Plant Extracts
Molecular Docking Simulation of Phenolics towards Tyrosinase, Phenolic Content, and Radical Scavenging Activity of Some Zingiberaceae Plant Extracts Open
In Indonesia, plants have been indigenously used to treat various diseases and as cosmetics. It is always challenging to explore the molecular interactions of phenolic compounds towards the levels of constituents that contribute to the bio…
View article: Selenium Organic Content Prediction in Jengkol (Archidendron pauciflorum) and Its Molecular Interaction with Cardioprotection Receptors PPAR-γ, NF-κB, and PI3K
Selenium Organic Content Prediction in Jengkol (Archidendron pauciflorum) and Its Molecular Interaction with Cardioprotection Receptors PPAR-γ, NF-κB, and PI3K Open
Selenium (Se) is a trace mineral found in plants with a distinct sulfuric odor that is cardioprotective and reported to have low toxicity. West Java, Indonesia, has a variety of plants with a distinct odor that are consumed raw, such as je…
View article: Synthesis of Mesoporous Silica Imprinted Salbutamol with Two TEOS/MTES Ratio Compositions through the Direct Incorporation Method for Salbutamol Separation
Synthesis of Mesoporous Silica Imprinted Salbutamol with Two TEOS/MTES Ratio Compositions through the Direct Incorporation Method for Salbutamol Separation Open
Molecularly imprinted mesoporous silica (MIPMS) is one of the methods to improve site accessibility molecule target on molecularly imprinted polymer (MIP) for application in solid-phase extraction (SPE). The MIPMS was prepared using salbut…
View article: The Oral Health and Comorbid Diseases Knowledge Between Urban and Rural Community during Pandemic
The Oral Health and Comorbid Diseases Knowledge Between Urban and Rural Community during Pandemic Open
The restriction of social mobility and activity during the COVID-19 pandemic has been implemented to stop the deadly transmission of the SARS-CoV2 virus. People are forced to stay at home and strictly perform the COVID-19 health protocol i…
View article: Molecular Dynamic Study of Mechanism Underlying Nature of Molecular Recognition and the Role of Crosslinker in the Synthesis of Salmeterol-Targeting Molecularly Imprinted Polymer for Analysis of Salmeterol Xinafoate in Biological Fluid
Molecular Dynamic Study of Mechanism Underlying Nature of Molecular Recognition and the Role of Crosslinker in the Synthesis of Salmeterol-Targeting Molecularly Imprinted Polymer for Analysis of Salmeterol Xinafoate in Biological Fluid Open
The rational preparation of molecularly imprinted polymers (MIPs) in order to have selective extraction of salmeterol xinafoate (SLX) from serum was studied. SLX is an acting β-adrenergic receptor agonist used in the treatment of asthma an…
View article: An Update on the Use of Molecularly Imprinted Polymers in Beta-Blocker Drug Analysis as a Selective Separation Method in Biological and Environmental Analysis
An Update on the Use of Molecularly Imprinted Polymers in Beta-Blocker Drug Analysis as a Selective Separation Method in Biological and Environmental Analysis Open
Beta-blockers are antihypertensive drugs and can be abused by athletes in some sport competitions; it is therefore necessary to monitor beta-blocker levels in biological samples. In addition, beta-blocker levels in environmental samples ne…
View article: Pharmacological Activities of Soursop (Annona muricata Lin.)
Pharmacological Activities of Soursop (Annona muricata Lin.) Open
Soursop (Annona muricata Lin.) is a plant belonging to the Annonaceae family that has been widely used globally as a traditional medicine for many diseases. In this review, we discuss the traditional use, chemical content, and pharmacologi…
View article: Genetic variation of ABCB1 (rs1128503, rs1045642) and CYP2E1 rs3813867 with the duration of tuberculosis therapy: a pilot study among tuberculosis patients in Indonesia
Genetic variation of ABCB1 (rs1128503, rs1045642) and CYP2E1 rs3813867 with the duration of tuberculosis therapy: a pilot study among tuberculosis patients in Indonesia Open
Objective The risk of contracting tuberculosis (TB) and the efficacy of TB therapy are affected by several factors, including genetic variation among populations. In the Indonesian population, data on the genes involved in drug transport a…
View article: Antiproliferation Activity and Apoptotic Mechanism of Soursop (Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells
Antiproliferation Activity and Apoptotic Mechanism of Soursop (Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells Open
Therefore, the leaves of the medicinal plant A. muricata contained compounds that on extraction exerted a highly effective activity as an anticancer treatment for breast cancer via induced apoptotic cell death.
View article: Isolation and Characterization Chemical Compounds From N-Hexane Extract of Zodia Leaves (Evodia suaveolens Scheff.)
Isolation and Characterization Chemical Compounds From N-Hexane Extract of Zodia Leaves (Evodia suaveolens Scheff.) Open
Zodia (Evodia suaveolens Scheff.) (Rutaceae) is one of Indonesia's native plants, which comes from Papua which is widely used as traditional medicine. Empirically, zodia leaves are used as anti-mosquitoes, dysentery drugs, boiled bark is u…
View article: An Update on Molecularly Imprinted Polymer Design through a Computational Approach to Produce Molecular Recognition Material with Enhanced Analytical Performance
An Update on Molecularly Imprinted Polymer Design through a Computational Approach to Produce Molecular Recognition Material with Enhanced Analytical Performance Open
Molecularly imprinted polymer (MIP) computational design is expected to become a routine technique prior to synthesis to produce polymers with high affinity and selectivity towards target molecules. Furthermore, using these simulations red…
View article: Formulation of Coated Tablets Film of Jengkol Fruit Seeds (Pithecellobium lobatum Benth.) as A Selenium Herbal Supplement
Formulation of Coated Tablets Film of Jengkol Fruit Seeds (Pithecellobium lobatum Benth.) as A Selenium Herbal Supplement Open
The correlation between the high content of selenium (Se) in plasma and the low prevalence of cardiovascular disease has been published in previous epidemiological studies. The content of Se in the plasma is determined by daily intake. A p…
View article: Flavonoids of Morus, Ficus, and Artocarpus (Moraceae): A review on their antioxidant activity and the influence of climate on their biosynthesis
Flavonoids of Morus, Ficus, and Artocarpus (Moraceae): A review on their antioxidant activity and the influence of climate on their biosynthesis Open
Pharmacognostical studies on the leaves of Ficus altissima blumeNagiat T Hwisa, Babu Rao Chandu, Prakash Katakam and Srikanth Nama
View article: Selenium species in vegetables: benefits and toxicity for the body
Selenium species in vegetables: benefits and toxicity for the body Open
Background: Selenium is one of the essential trace elements in various biological body functions. The main source of Selenium in the body is food, one of which is vegetables. Vegetables collect Selenium from the soil which is then converte…
View article: The role of selenium in cell survival and its correlation with protective effects against cardiovascular disease: A literature review
The role of selenium in cell survival and its correlation with protective effects against cardiovascular disease: A literature review Open
Selenium is a trace element that provides protection against cellular damage and death. Previous research using several types of cells identified anti-oxidant, anti-inflammatory, and anti-apoptotic effects for selenium. One of the diseases…
View article: Correlation study between gastronomy culture and content of selenium towards prevalence of cardiovascular and diabetes in West Java, Indonesia
Correlation study between gastronomy culture and content of selenium towards prevalence of cardiovascular and diabetes in West Java, Indonesia Open
Different areas have varying concentrations of Se in plants that grow in the region. The gastronomy culture and Se content may play a role to increase or decrease cardiovascular and diabetes prevalence in that area.
View article: The Pharmacokinetic Drug-Drug Interactions of Andrographis paniculata and Ibuprofen in the Plasma of Healthy Oryctolagus cuniculus Rabbits
The Pharmacokinetic Drug-Drug Interactions of Andrographis paniculata and Ibuprofen in the Plasma of Healthy Oryctolagus cuniculus Rabbits Open
An HPLC method was developed and validated for the pharmacokinetic drug-drug interaction between Andrographis paniculata and ibuprofen in the plasma of Oryctolagus cuniculus rabbits after a single oral administration of the mixture. Nine h…
View article: Quality of life of patients receiving a single or combination of calcium channel blocker-angiotensin receptor blocker: A cross-sectional study in West Java, Indonesia
Quality of life of patients receiving a single or combination of calcium channel blocker-angiotensin receptor blocker: A cross-sectional study in West Java, Indonesia Open
The prevalence of hypertension, based on the Indonesian Basic Health Research 2018, was 34.1%.Hypertensive patients usually show a low quality of life (QoL) due to their lifelong drug dependence.This cross-sectional study was conducted to …
View article: Modification of Extraction Methods on Determining Simeticone Suspension Using FTIR Method
Modification of Extraction Methods on Determining Simeticone Suspension Using FTIR Method Open
Antacids dosage form are a class of drugs used to chemically bind and neutralize stomach acid. Simethicone is one of the antacids that works as an antiflatulant. In an effort to guarantee the quality of a preparation, a valid analysis meth…
View article: Potential Natural Dual Agonist PPARα/γ-induced Antidiabetic and Antidyslipidemic Properties of Safrole-Free Nutmeg Seed (Myristica fragrans Houtt) Extract
Potential Natural Dual Agonist PPARα/γ-induced Antidiabetic and Antidyslipidemic Properties of Safrole-Free Nutmeg Seed (Myristica fragrans Houtt) Extract Open
Background: Nutmeg (Myristica fragrans Houtt) has the potential to control blood glucose and lipid levels. However, it contains safrole compounds, which are dangerous when humans consume them. Objective: In this study, we eliminated safrol…
View article: Quantification of Formaldehyde Residue in Wet Noodles Marketed in Indonesia using RP-HPLC Derivatization Method
Quantification of Formaldehyde Residue in Wet Noodles Marketed in Indonesia using RP-HPLC Derivatization Method Open
Illegal practices of formaldehyde as preservatives in wet noodles have been proven. These formaldehyde-preserved wet noodles are sold in West Java, Indonesia. This compound may be harmful to the body due to a decreasing of blood pressure, …
View article: Pharmacophore modeling and molecular docking of phytoconstituents in Morus sp. and Arcangelisia flava against nitric oxide synthase for antiinflammatory discovery
Pharmacophore modeling and molecular docking of phytoconstituents in Morus sp. and Arcangelisia flava against nitric oxide synthase for antiinflammatory discovery Open
Structure activity relationship studies of synthesised pyrazolone derivatives of imidazole, benzimidazole and benztriazole moiety for anti-inflammatory activityJulee P. Soni,Dhrubo Jyoti Sen, Kamal M. Modh
View article: Pharmacokinetics of 10‑gingerol and 6‑shogaol in the plasma of healthy subjects treated with red ginger (Zingiber officinale var. Rubrum) suspension
Pharmacokinetics of 10‑gingerol and 6‑shogaol in the plasma of healthy subjects treated with red ginger (Zingiber officinale var. Rubrum) suspension Open
Red ginger (Zingiber officinale var. Rubrum) is among the most widely consumed medicinal herbs in Indonesia. Ginger rhizome contains phenol compounds including gingerol and shogaol. 10-gingerol has been reported to exhibit the greatest ant…
View article: <i>Lactobacillus plantarum</i> IS-10506 probiotic administration increases amlodipine absorption in a rabbit model
<i>Lactobacillus plantarum</i> IS-10506 probiotic administration increases amlodipine absorption in a rabbit model Open
Objective Probiotics are beneficial in human health. In this study, we investigated the effect of probiotics on absorption of amlodipine, a dihydropyridine calcium antagonist used in the treatment of angina and hypertension, in a rabbit mo…
View article: Modulation of Caspase-3 Expression by Arcangelisia flava Post Acetaminophen-Induced Hepatotoxicity in Rat’s Liver
Modulation of Caspase-3 Expression by Arcangelisia flava Post Acetaminophen-Induced Hepatotoxicity in Rat’s Liver Open
BACKGROUND: Acetaminophen, when used at low doses is a safe drug, but at higher doses it induces apoptosis in hepatoma cells. Arcangelisia flava that grows widely in Kalimantan Island, Indonesia, contains berberine which is effective in pr…