Mutian Zhang
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View article: Mechanism-driven strengthening of MAX phase ceramics by Ti <sub>3</sub>C <sub>2</sub>T <sub> <i>x</i> </sub> MXene: A comparative study on Cr <sub>2</sub>AlC and Ta <sub>2</sub>AlC
Mechanism-driven strengthening of MAX phase ceramics by Ti <sub>3</sub>C <sub>2</sub>T <sub> <i>x</i> </sub> MXene: A comparative study on Cr <sub>2</sub>AlC and Ta <sub>2</sub>AlC Open
MAX-phase ceramics combine metallic and ceramic characteristics, while their two-dimensional (2D) derivatives, MXenes, have shown great potential as reinforcements for high-temperature structural applications. Leveraging the structural sim…
View article: CROSS-COUNTRY COMPARISONS OF FUNCTIONING AND CARDIOVASCULAR RISKS IN OLDER ADULTS
CROSS-COUNTRY COMPARISONS OF FUNCTIONING AND CARDIOVASCULAR RISKS IN OLDER ADULTS Open
Life expectancy at birth in China has increased more than 20 years over the past 50 years and is one year higher than in the US in 2021. Whether the rapid improvement in Chinese life expectancy has been accompanied by similar changes in ot…
View article: Social network and mental health of Chinese immigrants in affordable senior housing during the COVID-19 pandemic: a mixed-methods study
Social network and mental health of Chinese immigrants in affordable senior housing during the COVID-19 pandemic: a mixed-methods study Open
Knowledge built in this study can inform respondence to future crises like the COVID-19 pandemic in affordable housing settings serving older immigrant populations.
View article: Improving the solubility of pseudo-hydrophobic Alzheimer’s Disease medicinal chemicals through co-crystal formulation
Improving the solubility of pseudo-hydrophobic Alzheimer’s Disease medicinal chemicals through co-crystal formulation Open
Natural products are ligands and potential inhibitors of Alzheimer’s disease (AD) tau. Dihydromyricetin (DHM) is a CNS active natural product. Despite having signature polyphenolic character, DHM is ostensibly hydrophobic owing to intermol…
View article: Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition
Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition Open
There continues to be interest in targeting epigenetic “readers, writers, and erasers” for the treatment of cancer and other pathologies. However, a mechanistic understanding is frequently lacking for the synergy observed when combining de…
View article: Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition
Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition Open
There continues to be interest in targeting epigenetic “readers, writers, and erasers” for the treatment of cancer and other pathologies. However, a mechanistic understanding is frequently lacking for the synergy observed when combining de…
View article: Supplementary Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition
Supplementary Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition Open
Fig S1 shows HDAC3 knockdown, Fig S2 shows CCAR2 acetylation in SW480 colon cancer cells. Fig S3 shows mass spectrometry data, Fig S4 shows acetylation mutant data, Fig S5 shows a Working model, Fig S6 shows genetically encoded acetylation…
View article: Supplementary Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition
Supplementary Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition Open
Fig S1 shows HDAC3 knockdown, Fig S2 shows CCAR2 acetylation in SW480 colon cancer cells. Fig S3 shows mass spectrometry data, Fig S4 shows acetylation mutant data, Fig S5 shows a Working model, Fig S6 shows genetically encoded acetylation…
View article: Explainable Predictions of Multi-Component Oxides Enabled by Attention-Based Neural Networks
Explainable Predictions of Multi-Component Oxides Enabled by Attention-Based Neural Networks Open
View article: SOCIAL NETWORK AND MENTAL HEALTH OF OLDER CHINESE IMMIGRANTS IN AFFORDABLE SENIOR HOUSING DURING THE COVID-19 PANDEMIC
SOCIAL NETWORK AND MENTAL HEALTH OF OLDER CHINESE IMMIGRANTS IN AFFORDABLE SENIOR HOUSING DURING THE COVID-19 PANDEMIC Open
Chinese older immigrants who live in senior housing communities are at high risks of experiencing discrimination and social isolation during the COVID-19 pandemic. This study examines how and to what extent the pandemic has affected this p…
View article: A SCOPING REVIEW OF HOW NURSING HOME STAFFING LEVELS AND QUALITY OF CARE ARE MEASURED
A SCOPING REVIEW OF HOW NURSING HOME STAFFING LEVELS AND QUALITY OF CARE ARE MEASURED Open
The Centers for Medicare & Medicaid Services (CMS) is the largest payer of nursing home care in the US. CMS defines staffing levels as hours per resident day (HPRD) and staff turnover rates; it defines quality of care as nurse staffing lev…
View article: DOES RACE MATTER IN HEALTH MESSAGING? IMPACT OF RACE CONCORDANCE ON PALLIATIVE CARE KNOWLEDGE SCORE
DOES RACE MATTER IN HEALTH MESSAGING? IMPACT OF RACE CONCORDANCE ON PALLIATIVE CARE KNOWLEDGE SCORE Open
Palliative care (PC) programs have expanded rapidly across the United States in the last decade. However, there remains a wide disparity in access to PC among ethnic minorities. Therefore, it is necessary and critical to develop specific h…
View article: A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis Open
View article: Effects of bromelain on the quality of smoked salted duck
Effects of bromelain on the quality of smoked salted duck Open
This study was aimed to assess the effects of bromelain on the eating quality of smoked salted duck. Whole ducks were marinated with different doses of bromelain (300 U/g, 600 U/g, 900 U/g, 1,200 U/g and 1,500 U/g), while the group without…
View article: Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells
Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells Open
There is growing evidence that DNA repair factors have clinical value for cancer treatment. Nucleotide excision repair (NER) proteins, including excision repair cross-complementation group 2 (ERCC2), play a critical role in maintaining gen…
View article: Genome-wide DNA methylation profiling of leukocytes identifies CpG methylation signatures of aggressive prostate cancer.
Genome-wide DNA methylation profiling of leukocytes identifies CpG methylation signatures of aggressive prostate cancer. Open
Most of screening-detected prostate cancer (PCa) are indolent and not lethal. Biomarkers that can predict aggressive diseases independently of clinical features are needed to improve risk stratification of localized PCa patients and reduce…
View article: Hydroxylated high-entropy alloy as highly efficient catalyst for electrochemical oxygen evolution reaction
Hydroxylated high-entropy alloy as highly efficient catalyst for electrochemical oxygen evolution reaction Open
View article: Targeting of KDM5A by miR-421 in Human Ovarian Cancer Suppresses the Progression of Ovarian Cancer Cells
Targeting of KDM5A by miR-421 in Human Ovarian Cancer Suppresses the Progression of Ovarian Cancer Cells Open
Fang Ren, Christina Shrestha, Huirong Shi, Fangfang Sun, Minghui Zhang, Yuan Cao, Gailing Li Department of Gynecology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Fang RenDe…
View article: Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia
Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia Open
View article: LiBis: An ultrasensitive alignment method for low-input bisulfite sequencing
LiBis: An ultrasensitive alignment method for low-input bisulfite sequencing Open
The cell-free DNA (cfDNA) methylation profile in liquid biopsies has been utilized to diagnose early-stage disease and estimate therapy response. However, in typical clinical settings, only very small amounts of cfDNA can be purified. Whol…
View article: GsmPlot: a web server to visualize epigenome data in NCBI
GsmPlot: a web server to visualize epigenome data in NCBI Open
View article: Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition
Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition Open
There continues to be interest in targeting epigenetic “readers, writers, and erasers” for the treatment of cancer and other pathologies. However, a mechanistic understanding is frequently lacking for the synergy observed when combining de…
View article: pH and redox dual-responsive copolymer micelles with surface charge reversal for co-delivery of all-trans-retinoic acid and paclitaxel for cancer combination chemotherapy
pH and redox dual-responsive copolymer micelles with surface charge reversal for co-delivery of all-trans-retinoic acid and paclitaxel for cancer combination chemotherapy Open
Yanqiu Zhang,1,2,* Lianjun Peng,3,* Jiahui Chu,4 Ming Zhang,5 Lizhu Sun,1,2 Bin Zhong,5 Qiyong Wu5 1Department of Oncology and Hematology, Shuyang Hospital Affiliated to Xuzhou Medical University, Suqian 223600, China; 2Department of Oncol…
View article: ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer
ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer Open
View article: A Quality Assurance Approach for Linear Accelerator Mechanical Isocenters with Portal Images
A Quality Assurance Approach for Linear Accelerator Mechanical Isocenters with Portal Images Open
Purpose: With usually a millimeter-level PTV margin, stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) pose a stringent requirement on the isocentricity of the Linac. This requirement is partly fulfilled by rou…
View article: Using weighted power mean for equivalent square estimation
Using weighted power mean for equivalent square estimation Open
Purpose Equivalent Square ( ES ) enables the calculation of many radiation quantities for rectangular treatment fields, based only on measurements from square fields. While it is widely applied in radiotherapy, its accuracy, especially for…
View article: A review of nonstandardized applicators digitization in Nucletron™ <scp>HDR</scp> procedures
A review of nonstandardized applicators digitization in Nucletron™ <span>HDR</span> procedures Open
The major errors in HDR procedures were failures to enter the correct treatment distance, which could be caused by either entering wrong transmission lengths or imprecisely digitizing the dwelling positions. Most of those errors were not e…
View article: Comparison of the Role of a Central Location Test versus a Home Usage Test on Consumer Perception of Ready-to-Mix Protein Beverages.
Comparison of the Role of a Central Location Test versus a Home Usage Test on Consumer Perception of Ready-to-Mix Protein Beverages. Open
View article: Response to the comments on “The feasibility study of a hybrid coplanar arc technique versus hybrid intensity-modulated radiotherapy in treatment of early-stage left-sided breast cancer with simultaneous-integrated boost. J Med Phys 2017;42:1-8”
Response to the comments on “The feasibility study of a hybrid coplanar arc technique versus hybrid intensity-modulated radiotherapy in treatment of early-stage left-sided breast cancer with simultaneous-integrated boost. J Med Phys 2017;42:1-8” Open
View article: A feasibility study of applying thermal imaging to assist quality assurance of high-dose rate brachytherapy
A feasibility study of applying thermal imaging to assist quality assurance of high-dose rate brachytherapy Open
Aim: High-dose rate (HDR) brachytherapy poses a special challenge to radiation safety and quality assurance (QA) due to its high radioactivity, and it is thus critical to verify the HDR source location and its radioactive strength. This st…