Muya Chen
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View article: Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs
Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs Open
The genetic basis of complex traits and phenotypic differentiation remains unclear in pigs. Using nine genomes—seven of which were newly generated, high‐quality de novo assembled genomes—and 1081 resequencing genomes, we built a pan‐genome…
View article: Multi-omics analysis reveals signatures of selection and loci associated with complex traits in pigs
Multi-omics analysis reveals signatures of selection and loci associated with complex traits in pigs Open
Selection signatures that contribute to phenotypic diversity, especially morphogenesis in pigs, remain to be further elucidated. To reveal the regulatory role of genetic variations in phenotypic differences between Eastern and Western pig …
View article: Integration of multi-omics data reveals cis-regulatory variants that are associated with phenotypic differentiation of eastern from western pigs
Integration of multi-omics data reveals cis-regulatory variants that are associated with phenotypic differentiation of eastern from western pigs Open
Background The genetic mechanisms that underlie phenotypic differentiation in breeding animals have important implications in evolutionary biology and agriculture. However, the contribution of cis-regulatory variants to pig phenotypes is p…
View article: Additional file 2 of Integration of multi-omics data reveals cis-regulatory variants that are associated with phenotypic differentiation of eastern from western pigs
Additional file 2 of Integration of multi-omics data reveals cis-regulatory variants that are associated with phenotypic differentiation of eastern from western pigs Open
Additional file 2: Table S1. Statistics of the resequencing data produced by this study. Table S2. Overview of the data that were downloaded from NCBI. Table S3. Statistics of the NCBI data—according to run_ID. Table S4. Primers used in th…
View article: Landscape of tissue-specific RNA Editome provides insight into co-regulated and altered gene expression in pigs (<i>Sus-scrofa</i>)
Landscape of tissue-specific RNA Editome provides insight into co-regulated and altered gene expression in pigs (<i>Sus-scrofa</i>) Open
RNA editing generates genetic diversity in mammals by altering amino acid sequences, miRNA targeting site sequences, influencing the stability of targeted RNAs, and causing changes in gene expression. However, the extent to which RNA editi…
View article: Landscape of tissue-specific RNA Editome provides insight into co-regulated and altered gene expression in pigs (<i>Sus-scrofa</i>)
Landscape of tissue-specific RNA Editome provides insight into co-regulated and altered gene expression in pigs (<i>Sus-scrofa</i>) Open
RNA editing generates genetic diversity in mammals by altering amino acid sequences, miRNA targeting site sequences, influencing the stability of targeted RNAs, and causing changes in gene expression. However, the extent to which RNA editi…
View article: Landscape of tissue-specific RNA Editome provides insight into co-regulated and altered gene expression in pigs (<i>Sus-scrofa</i>)
Landscape of tissue-specific RNA Editome provides insight into co-regulated and altered gene expression in pigs (<i>Sus-scrofa</i>) Open
RNA editing generates genetic diversity in mammals by altering amino acid sequences, miRNA targeting site sequences, influencing the stability of targeted RNAs, and causing changes in gene expression. However, the extent to which RNA editi…
View article: A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development
A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development Open
DNA methylation is important for the epigenetic regulation of gene expression and plays a critical role in mammalian development. However, the dynamic regulation of genome-wide DNA methylation in skeletal muscle development remains largely…
View article: Comprehensive Profiles of mRNAs and miRNAs Reveal Molecular Characteristics of Multiple Organ Physiologies and Development in Pigs
Comprehensive Profiles of mRNAs and miRNAs Reveal Molecular Characteristics of Multiple Organ Physiologies and Development in Pigs Open
The pig (Sus scrofa) is not only an important livestock animal but also widely used as a biomedical model.However, the understanding of the molecular characteristics of organs and of the developmental skeletal muscle of the pig is severely…
View article: Chromosome-scale<i>de novo</i>assembly and phasing of a Chinese indigenous pig genome
Chromosome-scale<i>de novo</i>assembly and phasing of a Chinese indigenous pig genome Open
Chinese indigenous pigs differ significantly from Western commercial pig breeds in phenotypic and genomic characteristics. Thus, building a high-quality reference genome for Chinese indigenous pigs is pivotal to exploring gene function, ge…
View article: Comprehensive Profiles of mRNAs and miRNAs Reveal Molecular Characteristics of Multiple Organ Physiologies and Development in Pigs
Comprehensive Profiles of mRNAs and miRNAs Reveal Molecular Characteristics of Multiple Organ Physiologies and Development in Pigs Open
The pig (Sus scrofa) is not only an important livestock animal but also widely used as a biomedical model. However, the understanding of the molecular characteristics of organs and of the developmental skeletal muscle of the pig is severel…
View article: IS<em>Ecp1</em>-mediated transposition of chromosome-borne <em>bla</em><sub>CMY-2</sub> into an endogenous ColE1-like plasmid in <em>Escherichia coli</em>
IS<em>Ecp1</em>-mediated transposition of chromosome-borne <em>bla</em><sub>CMY-2</sub> into an endogenous ColE1-like plasmid in <em>Escherichia coli</em> Open
Our results firstly demonstrated that ISEcp1 mediated a transposition of chromosome-borne blaCMY-2 into an endogenous ColE1-like plasmid by electroporation. Amplification of the blaCMY-2 gene facilitates the strain adaptation to a changed …
View article: Multilevel selection of bcrABDR-mediated bacitracin resistance in Enterococcus faecalis from chicken farms
Multilevel selection of bcrABDR-mediated bacitracin resistance in Enterococcus faecalis from chicken farms Open
In this study we isolated 109 Enterococcus faecalis from chicken faecal samples in 6 provinces of China to investigate the prevalence and transmission mechanism of the bacitracin resistance locus bcrABDR in E. faecalis . Thirty-seven bcrAB…