Muyan Chen
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View article: Author response: Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome
Author response: Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome Open
View article: Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome
Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome Open
The calcitonin (CT) family of related peptides exerts diverse physiological effects in mammals via two G-protein coupled receptors: CTR and the CTR-like receptor CLR. Phylogenetic analysis of CT-type signaling has revealed the presence of …
View article: Author response: Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome
Author response: Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome Open
View article: Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome
Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome Open
The calcitonin (CT) family of related peptides exerts diverse physiological effects in mammals via two G-protein coupled receptors: CTR and the CTR-like receptor CLR. Phylogenetic analysis of CT-type signaling has revealed the presence of …
View article: Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by reducing CCL2-mediated macrophage infiltration in sensory ganglia and sciatic nerve
Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by reducing CCL2-mediated macrophage infiltration in sensory ganglia and sciatic nerve Open
View article: Dual-Axis Innovation in Sea Cucumber Reproduction: A High-Efficiency Spawning Protocol and Sex-Specific Stress Response Mechanism
Dual-Axis Innovation in Sea Cucumber Reproduction: A High-Efficiency Spawning Protocol and Sex-Specific Stress Response Mechanism Open
View article: Genome-Wide DNA Methylation Profiling Reveals Epigenetic Regulation of Sex Differentiation and Gonadal Development in Apostichopus Japonicus
Genome-Wide DNA Methylation Profiling Reveals Epigenetic Regulation of Sex Differentiation and Gonadal Development in Apostichopus Japonicus Open
View article: Genome-Wide DNA Methylation Profiling Reveals Epigenetic Regulation of Sex Differentiation and Gonadal Development in Apostichopus Japonicus
Genome-Wide DNA Methylation Profiling Reveals Epigenetic Regulation of Sex Differentiation and Gonadal Development in Apostichopus Japonicus Open
View article: Aaopsin4 Drives Dual Phototransduction Pathways and Blue-Light-Induced Behavior in Asterias Amurensis: Molecular Structure, Expression Profile and Function Insights
Aaopsin4 Drives Dual Phototransduction Pathways and Blue-Light-Induced Behavior in Asterias Amurensis: Molecular Structure, Expression Profile and Function Insights Open
View article: Identification of a candidate sex determination region and sex-specific molecular markers based on whole-genome re‑sequencing in the sea star <i>Asterias amurensis</i>
Identification of a candidate sex determination region and sex-specific molecular markers based on whole-genome re‑sequencing in the sea star <i>Asterias amurensis</i> Open
Sex determination systems are diverse in echinoderms, however, our understanding is still very limited in this research field, especially for Asteroidea species. The northern Pacific seastar, Asterias amurensis, has attracted widespread co…
View article: Functional evolution of thyrotropin-releasing hormone neuropeptides: Insights from an echinoderm
Functional evolution of thyrotropin-releasing hormone neuropeptides: Insights from an echinoderm Open
Feeding behavior is regulated by a complex network of endogenous neuropeptides. In chordates, this role is suggested to be under the control of diverse factors including thyrotropin-releasing hormone (TRH). However, whether this regulatory…
View article: Chemokine CXCL13–CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases
Chemokine CXCL13–CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases Open
Chronic pain dramatically affects life qualities of the sufferers. It has posed a heavy burden to both patients and the health care system. However, the current treatments for chronic pain are usually insufficient and cause many unwanted s…
View article: Identification of research gaps to improve care for healthy ageing:<b>a scoping review</b>
Identification of research gaps to improve care for healthy ageing:<b>a scoping review</b> Open
Objective Several research gaps affect the improvement of care for healthy ageing. Their identification is crucial to developing a specific research prioritisation agenda supporting progress at the micro (clinical), meso (service delivery)…
View article: Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome
Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome Open
The calcitonin (CT) family of related peptides exert their diverse physiological effects in mammals via two G-protein coupled receptors, CTR and the CTR-like receptor CLR. Analysis of the phylogenetic distribution of CT-type signaling has …
View article: Author response: Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome
Author response: Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome Open
View article: Functional characterization of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome
Functional characterization of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome Open
The calcitonin (CT) family of related peptides exerts diverse physiological effects in mammals via two G-protein-coupled receptors: CTR and the CTR-like receptor CLR. Phylogenetic analysis of CT-type signaling has revealed the presence of …
View article: Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome
Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome Open
The calcitonin (CT) family of related peptides exerts diverse physiological effects in mammals via two G-protein coupled receptors: CTR and the CTR-like receptor CLR. Phylogenetic analysis of CT-type signaling has revealed the presence of …
View article: Development and application of molecular markers in fisheries, aquaculture, and industry of representative temperate and tropical sea cucumbers: a review
Development and application of molecular markers in fisheries, aquaculture, and industry of representative temperate and tropical sea cucumbers: a review Open
Sea cucumber has emerged as a crucial economic species in aquaculture in China because of its remarkable nutritional and medicinal value. However, wild sea cucumber populations have experienced a decline due to overfishing and environmenta…
View article: Electroacupuncture Alleviates Paclitaxel-induced Peripheral Neuropathy by Reducing CCL2-mediated Macrophage Infiltration in Sensory Ganglia and Sciatic Nerve
Electroacupuncture Alleviates Paclitaxel-induced Peripheral Neuropathy by Reducing CCL2-mediated Macrophage Infiltration in Sensory Ganglia and Sciatic Nerve Open
Background: Paclitaxel-induced peripheral neuropathy (PIPN) is a common side effect accompanying paclitaxel chemotherapy, resulting in sensory abnormality and neuropathic pain. Conventional medications lack effectiveness on PIPN. Clinical …
View article: Evaluation of different types of adjuvants in a malaria transmission-blocking vaccine
Evaluation of different types of adjuvants in a malaria transmission-blocking vaccine Open
View article: IL-33/ST2 induces macrophage-dependent ROS production and TRPA1 activation that mediate pain-like responses by skin incision in mice
IL-33/ST2 induces macrophage-dependent ROS production and TRPA1 activation that mediate pain-like responses by skin incision in mice Open
Background: Insufficiently managed incisional (INC) pain severely affects patients' life quality and rehabilitation after a major operation. However, mechanisms underlying INC pain still remain poorly understood. Methods: A m…
View article: A dual-antigen malaria vaccine targeting Pb22 and Pbg37 was able to induce robust transmission-blocking activity
A dual-antigen malaria vaccine targeting Pb22 and Pbg37 was able to induce robust transmission-blocking activity Open
View article: Chromosome-level genome assembly of the northern Pacific seastar Asterias amurensis
Chromosome-level genome assembly of the northern Pacific seastar Asterias amurensis Open
Asterias amurensis has attracted widespread concern because of its population outbreaks, which has impacted fisheries and aquaculture, as well as disrupting local ecosystems. A high-quality reference genome is necessary to better investiga…
View article: Morphology and Chemical Messenger Regulation of Echinoderm Muscles
Morphology and Chemical Messenger Regulation of Echinoderm Muscles Open
The muscular systems of echinoderms play important roles in various physiological and behavioral processes, including feeding, reproduction, movement, respiration, and excretion. Like vertebrates, echinoderm muscle systems can be subdivide…
View article: A Putative Role of Vasopressin/Oxytocin-Type Neuropeptide in Osmoregulation and Feeding Inhibition of Apostichopus japonicus
A Putative Role of Vasopressin/Oxytocin-Type Neuropeptide in Osmoregulation and Feeding Inhibition of Apostichopus japonicus Open
Vasopressin/oxytocin (VP/OT)-type neuropeptide is an ancient neurophysin-associated neuropeptide and has been intensively studied to be involved in multiple physiological processes in protostomian and deuterostome vertebrates. However, lit…
View article: Characterization and expression profile of transient receptor potential channels in sea cucumber Apostichopus japonicus
Characterization and expression profile of transient receptor potential channels in sea cucumber Apostichopus japonicus Open
Background In the past few decades, heat waves and seasonal variation linked with global warming are causing frequent fluctuations of water temperature in aquatic environments, resulting in further challenges for marine organisms. As a poi…
View article: Chromosome-level genome assembly of <em>Asterias amurensis</em>
Chromosome-level genome assembly of <em>Asterias amurensis</em> Open
The final chromosome assembly and genome annotation information of northern Pacific seastar Asterias amurensis
View article: Chromosome-level genome assembly of <em>Asterias amurensis</em>
Chromosome-level genome assembly of <em>Asterias amurensis</em> Open
The final chromosome assembly and genome annotation information of northern Pacific seastar Asterias amurensis
View article: Nervous System Development and Neuropeptides Characterization in Embryo and Larva: Insights from a Non-Chordate Deuterostome, the Sea Cucumber Apostichopus japonicus
Nervous System Development and Neuropeptides Characterization in Embryo and Larva: Insights from a Non-Chordate Deuterostome, the Sea Cucumber Apostichopus japonicus Open
Here, we described the complex nervous system at five early developmental stages (blastula, gastrula, auricularia, doliolaria and pentactula) of a holothurian species with highly economic value, Apostichopus japonicus. The results revealed…
View article: Metabolic response of the sea cucumber Apostichopus japonicus during the estivation-arousal cycles
Metabolic response of the sea cucumber Apostichopus japonicus during the estivation-arousal cycles Open
Estivation is a widespread survival strategy for dealing with adverse environmental conditions such as high temperature, low oxygen and lack of water or food, which has been reported across multiple vertebrate and invertebrate species. The…