Explanipedia

miRNA‐6236 Regulation of Postischemic Skeletal Muscle Angiogenesis Open

Arul M. Mani, Victor Lamin, Ronan C. Peach, Erwin Friesen, Thomas Wong , et al. · 2024

Background Peripheral arterial disease affects >200 million people worldwide and is characterized by impaired blood flow to the lower extremities. There are no effective medical treatments available. Using the mouse hind‐limb ischemia mode…

Novel components in the nuclear factor-kappa B (NF-κB) signaling pathways of endothelial cells under hyperglycemic-ischemic conditions Open

Madhu V. Singh, Thomas K. S. Wong, Sonia Moorjani, Arul M. Mani, Ayotunde O. Dokun · 2024

Diabetes worsens the outcomes of a number of vascular disorders including peripheral arterial disease (PAD) at least in part through induction of chronic inflammation. However, in experimental PAD, recovery requires the nuclear factor-kapp…

FRI625 Diabetic Ischemic Skeletal Muscle Injury Occurs Through Pkc-beta/sp1 Regulation Of Bag3 Expression Open

Arul M. Mani, Victor Lamin, Thomas Wong, Madhu V. Singh, Ayotunde O. Dokun · 2023

Disclosure: A. Mani: None. V. Lamin: None. T. Wong: None. M.V. Singh: None. A.O. Dokun: None. Peripheral arterial disease (PAD) affects more than 200 million people worldwide and is characterized by impaired blood flow to the lower extremi…

Diabetes mellitus in peripheral artery disease: Beyond a risk factor Open

Madhu V. Singh, Ayotunde O. Dokun · 2023

Peripheral artery disease (PAD) is one of the major cardiovascular diseases that afflicts a large population worldwide. PAD results from occlusion of the peripheral arteries of the lower extremities. Although diabetes is a major risk facto…

Endothelial Progenitor Cells and Macrophage Subsets Recruitment in Postischemic Mouse Hind Limbs Open

Victor Lamin, Arul M. Mani, Madhu V. Singh, Ayotunde O. Dokun · 2023

Introduction: Peripheral arterial disease (PAD) occurs from atherosclerotic obstruction of arteries in the lower extremities. Restoration of perfusion requires angiogenesis and arteriogenesis through migration and differentiation of endoth…

BAG3 Attenuates Ischemia-Induced Skeletal Muscle Necroptosis in Diabetic Experimental Peripheral Artery Disease Open

Arul M. Mani, Karthik Dhanabalan, Victor Lamin, Thomas Wong, Madhu V. Singh , et al. · 2022

Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, resulting in ischemic limb injuries. Individuals with diabetes and PAD typically have more severe ischemic limb injuries and limb amputations…

MicroRNA regulation of BAG3 Open

Madhu V. Singh, Karthik Dhanabalan, Joseph Verry, Ayotunde O. Dokun · 2022

B-cell lymphoma 2 (Bcl-2)-associated athanogene 3 (BAG3) protein is a member of BAG family of co-chaperones that modulates major biological processes, including apoptosis, autophagy, and development to promote cellular adaptive responses t…

Altering Early Life Gut Microbiota Has Long-Term Effect on Immune System and Hypertension in Spontaneously Hypertensive Rats Open

François M. Abboud, Michael Z. Cicha, Aaron C. Ericsson, Mark W. Chapleau, Madhu V. Singh · 2021

Hypertension is regulated by immunological components. Spontaneously hypertensive rats (SHR) display a large population of proinflammatory CD161 + immune cells. We investigated the effect of early post-natal gut microbiota on the developme…

GENOMIC EVIDENCES FOR THE OCCURRENCE OF LEARNING DISABILITIES Open

Sana Fatima, Madhu V. Singh · 2021

It is a well-established fact strongly supported by various studies that the occurrence of any sort of disorder since birth is a result of some or the other interference with the genetic setup of the child.Whether it is a direct inheritanc…

BLNK/BTK: Novel Components in the NF-kappa B Pathways of Endothelial Cells in Diabetic Condition Open

Madhu V. Singh, Thomas Wong, Ayotunde O. Dokun · 2021

Peripheral artery disease (PAD) is atherosclerotic occlusion of vessel outside the heart that most commonly affects the lower extremities. The effects of PAD-related ischemia are exacerbated under diabetic hyperglycemic conditions. Under i…

Inhibition of protein kinase C beta phosphorylation activates nuclear factor-kappa B and improves postischemic recovery in type 1 diabetes Open

Satyanarayana Alleboina, Thomas Wong, Madhu V. Singh, Ayotunde O. Dokun · 2020

Peripheral artery disease (PAD) is a major health problem and is caused by atherosclerosis in arteries outside the heart leading to impaired blood flow. The presence of diabetes significantly increases the likelihood of having worse outcom…

OR14-06 Inhibition of Protein Kinase C-beta2 Phosphorylation Restores Nuclear Factor-Kappa B Activation and Improves Peripheral Arterial Disease in Diabetes Open

Satyanarayana Alleboina, Madhu V. Singh, Thomas Wong, Ayotunde O. Dokun · 2020

Peripheral artery disease (PAD) is atherosclerotic occlusion of vessel outside the heart and most commonly affects the lower extremities. Diabetes (DM) accelerates the course and severity of PAD. Studies have shown that vascular endothelia…

SAT-632 Involvement of NF-κB-p65 in BAG3 Regulation After Stress Stimuli Open

Karthik Dhanabalan, Madhu V. Singh, Thomas Wong, Ayotunde O. Dokun · 2020

We previously identified the limb salvage QTL1 (LSQ-1) on mouse chromosome 7 as a locus that offered protection against ischemic injury following induction of hind limb ischemia (HLI) a model of experimental peripheral arterial disease (PA…

TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons Open

Runping Wang, Yongjun Lu, Michael Z. Cicha, Madhu V. Singh, Christopher J. Benson , et al. · 2019

The satiety effects and metabolic actions of cholecystokinin (CCK) have been recognized as potential therapeutic targets in obesity for decades. We identified a potentially novel Ca2+-activated chloride (Cl-) current (CaCC) that is induced…

Angiotensin II-induced hypertension and cardiac hypertrophy are differentially mediated by TLR3- and TLR4-dependent pathways Open

Madhu V. Singh, Michael Z. Cicha, Sarah Nunez, David K. Meyerholz, Mark W. Chapleau , et al. · 2019

Toll-like receptors (TLR) are key components of the innate immune system that elicit inflammatory responses through the adaptor proteins myeloid differentiation protein 88 (MyD88) and Toll-interleukin receptor domain-containing adaptor pro…

Autonomic regulation of the immune system in cardiovascular diseases Open

François M. Abboud, Madhu V. Singh · 2017

The autonomic nervous system is a powerful regulator of circulatory adjustments to acute hemodynamic stresses. Here we focus on new concepts that emphasize the chronic influence of the sympathetic and parasympathetic systems on cardiovascu…

Abnormal CD161+ immune cells and retinoic acid receptor–related orphan receptor γt–mediate enhanced IL-17F expression in the setting of genetic hypertension Open

Madhu V. Singh, Michael Z. Cicha, Santosh Kumar, David K. Meyerholz, Kaikobad Irani , et al. · 2017

Toll-Like Receptors, Hypertension, and an Antimalarial Drug Open

Madhu V. Singh · 2016

The role of the immune system in the pathogenesis of hypertensionis a growing area of research. Although the immunesystem had long been suspected to contribute to hypertension,only in the last decade have studies begun to define the roleso…

Dual Activation of TRIF and MyD88 Adaptor Proteins by Angiotensin II Evokes Opposing Effects on Pressure, Cardiac Hypertrophy, and Inflammatory Gene Expression Open

Madhu V. Singh, Michael Z. Cicha, David K. Meyerholz, Mark W. Chapleau, François M. Abboud · 2015

Hypertension is recognized as an immune disorder whereby immune cells play a defining role in the genesis and progression of the disease. The innate immune system and its component toll-like receptors are key determinants of the immunologi…

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