Mwelwa Chibuye
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View article: Whole genome characterisation of Enterotoxigenic<i>Escherichia coli</i>circulating in Zambia
Whole genome characterisation of Enterotoxigenic<i>Escherichia coli</i>circulating in Zambia Open
Background Enterotoxigenic Escherichia coli (ETEC) is a significant cause of diarrheal disease, particularly in low—and middle-income countries, including Zambia. ETEC pathogenesis is driven by colonisation factors (CF) and enterotoxins, a…
View article: Systematic review of associations between gut microbiome composition and stunting in under-five children
Systematic review of associations between gut microbiome composition and stunting in under-five children Open
View article: The Incidence and Risk Factors for Enterotoxigenic E. coli Diarrheal Disease in Children under Three Years Old in Lusaka, Zambia
The Incidence and Risk Factors for Enterotoxigenic E. coli Diarrheal Disease in Children under Three Years Old in Lusaka, Zambia Open
This study aimed to estimate the incidence and risk factors for Enterotoxigenic Escherichia coli (ETEC) diarrhea. This was a prospective cohort study of children recruited in a household census. Children were enrolled if they were 36 month…
View article: PA-836 Antimicrobial resistance patterns and molecular characterisation of shigella isolates from under-five children in Zambia
PA-836 Antimicrobial resistance patterns and molecular characterisation of shigella isolates from under-five children in Zambia Open
Background Shigella is one of the top five causative agents of childhood diarrhoea, particularly in lower-middle-income countries, and is one of the vaccine-preventable diseases prioritised for vaccine development by the WHO. The emergence…
View article: Association of biomarkers of enteric dysfunction, systemic inflammation, and growth hormone resistance with seroconversion to oral rotavirus vaccine: A lasso for inference approach
Association of biomarkers of enteric dysfunction, systemic inflammation, and growth hormone resistance with seroconversion to oral rotavirus vaccine: A lasso for inference approach Open
Background Rotavirus gastroenteritis remains a leading cause of morbidity and mortality despite the introduction of vaccines. Research shows there are several factors contributing to the reduced efficacy of rotavirus vaccines in low- and m…
View article: Prevalence of Diarrhoeagenic Escherichia coli among Children Aged between 0–36 Months in Peri-Urban Areas of Lusaka
Prevalence of Diarrhoeagenic Escherichia coli among Children Aged between 0–36 Months in Peri-Urban Areas of Lusaka Open
Diarrhoea is a major contributor to childhood morbidity and mortality in developing countries, with diarrhoeagenic Escherichia coli being among the top aetiological agents. We sought to investigate the burden and describe the diarrhoeageni…
View article: Safety, tolerability, and immunogenicity of an oral inactivated ETEC vaccine (ETVAX®) with dmLT adjuvant in healthy adults and children in Zambia: An age descending randomised, placebo-controlled trial
Safety, tolerability, and immunogenicity of an oral inactivated ETEC vaccine (ETVAX®) with dmLT adjuvant in healthy adults and children in Zambia: An age descending randomised, placebo-controlled trial Open
The trial is registered with the Pan African Clinical Trials Registry (PACTR Ref. 201905764389804) and a description of this clinical trial is available on: https://pactr.samrc.ac.za/Trial Design.
View article: Maternal and Infant Histo-Blood Group Antigen (HBGA) Profiles and Their Influence on Oral Rotavirus Vaccine (RotarixTM) Immunogenicity among Infants in Zambia
Maternal and Infant Histo-Blood Group Antigen (HBGA) Profiles and Their Influence on Oral Rotavirus Vaccine (RotarixTM) Immunogenicity among Infants in Zambia Open
Live-attenuated, oral rotavirus vaccines have significantly reduced rotavirus-associated diarrhoea morbidity and infant mortality. However, vaccine immunogenicity is diminished in low-income countries. We investigated whether maternal and …
View article: Impact of antibiotics on gut microbiome composition and resistome in the first years of life in low- to middle-income countries: A systematic review
Impact of antibiotics on gut microbiome composition and resistome in the first years of life in low- to middle-income countries: A systematic review Open
Background Inappropriate antimicrobial usage is a key driver of antimicrobial resistance (AMR). Low- and middle-income countries (LMICs) are disproportionately burdened by AMR and young children are especially vulnerable to infections with…
View article: Maternal and Infant Histo-Blood Group Antigens (Hbga) Profiles and It’s Influence on Oral Rotavirus Vaccine (Rotarix®) Immunogenicity Among Infants in Zambia
Maternal and Infant Histo-Blood Group Antigens (Hbga) Profiles and It’s Influence on Oral Rotavirus Vaccine (Rotarix®) Immunogenicity Among Infants in Zambia Open
Live-attenuated, oral rotavirus vaccines have significantly reduced rotavirus-associated diarrhoea morbidity and infant mortality. However, vaccine immunogenicity is diminished in low-income countries. We investigated whether maternal and …
View article: Depression-Mediating Pathways From Household Adversity to Antiretroviral Therapy Nonadherence Among Children and Adolescents Living With HIV in Zambia: A Structural Equation Modeling Approach
Depression-Mediating Pathways From Household Adversity to Antiretroviral Therapy Nonadherence Among Children and Adolescents Living With HIV in Zambia: A Structural Equation Modeling Approach Open
Background: In Zambia, half of children and adolescents living with HIV (CALWH) on antiretroviral therapy (ART) are virologically unsuppressed. Depressive symptoms are associated with ART nonadherence but have received insufficient attenti…
View article: Sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in Zambia
Sensitivity and predictive value of dysentery in diagnosing shigellosis among under five children in Zambia Open
Background Shigella is a leading cause of bacterial diarrhea morbidity and mortality affecting mainly children under five in the developing world. In Zambia, Shigella has a high prevalence of 34.7% in children with diarrhea and an attribut…
View article: Evaluation of ROTARIX® Booster Dose Vaccination at 9 Months for Safety and Enhanced Anti-Rotavirus Immunity in Zambian Children: A Randomised Controlled Trial
Evaluation of ROTARIX® Booster Dose Vaccination at 9 Months for Safety and Enhanced Anti-Rotavirus Immunity in Zambian Children: A Randomised Controlled Trial Open
Oral rotavirus vaccines show diminished immunogenicity in low-resource settings where rotavirus burden is highest. This study assessed the safety and immune boosting effect of a third dose of oral ROTARIX® (GlaxoSmithKline) vaccine adminis…
View article: Development of a diarrhoea severity scoring scale in a passive health facility-based surveillance system
Development of a diarrhoea severity scoring scale in a passive health facility-based surveillance system Open
Background Diarrhoeal disease remains a leading cause of death among children mostly in low and middle-income countries. Factors contributing to disease severity are complex and there is currently no consensus on a scoring tool for use in …
View article: Antimicrobial Susceptibility Patterns of Escherichia coli and Shigella Isolated from Stool Samples from Adults and Children in Zambia
Antimicrobial Susceptibility Patterns of Escherichia coli and Shigella Isolated from Stool Samples from Adults and Children in Zambia Open
Introduction Antimicrobial resistance (AMR) is a growing public health problem in low-to-middle income countries which have a high burden of infectious diseases. Poor antimicrobial stewardship in these regions has resulted in a rise in rep…
View article: Sexual debut and risk behaviors among orphaned and vulnerable children in Zambia: which protective deficits shape HIV risk?
Sexual debut and risk behaviors among orphaned and vulnerable children in Zambia: which protective deficits shape HIV risk? Open
Orphaned and vulnerable children (OVC) are not only affected by, but also rendered at-risk of, HIV due to overlapping deficits in protective assets, from school to household financial security. Drawing from a protective deficit framework, …
View article: Comparable exposure to SARS-CoV-2 in young children and healthcare workers in Zambia
Comparable exposure to SARS-CoV-2 in young children and healthcare workers in Zambia Open
Background:Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing global health crisis that has caused large scale morbidity and mortality. We aimed to determine the exposur…
View article: Integrated psychosocial, economic strengthening, and clinical service-delivery to improve health and resilience of adolescents living with HIV and their caregivers: Findings from a prospective cohort study in Zambia
Integrated psychosocial, economic strengthening, and clinical service-delivery to improve health and resilience of adolescents living with HIV and their caregivers: Findings from a prospective cohort study in Zambia Open
Background Children and youth are profoundly impacted groups in Zambia’s HIV epidemic. To evaluate delivery of integrated psychosocial, economic strengthening, and clinical services to HIV-affected households through the Zambia Family (ZAM…
View article: Zambia Family (ZAMFAM) cohort study
Zambia Family (ZAMFAM) cohort study Open
To evaluate delivery of integrated psychosocial, economic strengthening, and clinical services to HIV-affected households through the Zambia Family (ZAMFAM) Project, a prospective cohort study compared socio-economic, psychosocial, and hea…
View article: Benchmark assessment of orphaned and vulnerable children in areas of the Zambia Family (ZAMFAM) Project
Benchmark assessment of orphaned and vulnerable children in areas of the Zambia Family (ZAMFAM) Project Open
The US Agency for International Development and US President’s Emergency Plan for AIDS Relief (PEPFAR) are supporting the Zambia Family (ZAMFAM) project to strengthen comprehensive, integrated service delivery and support to children livin…