Mai P. Hoang
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View article: Dualistic Role of MITF in Uveal Melanoma: Defining Two Distinct Cellular Subpopulations With Prognostic and Therapeutic Implications
Dualistic Role of MITF in Uveal Melanoma: Defining Two Distinct Cellular Subpopulations With Prognostic and Therapeutic Implications Open
MITF delineates two UM subpopulations: (1) MITF-low tumors-slow proliferators with high invasive potential and inflammatory phenotype, and (2) MITF-high tumors-rapidly dividing cells with lower invasiveness and immunosuppressive properties…
View article: Cultural Adaptation of the World Health Organization’s iSupport Dementia Program for Family Carers of People Living with Dementia in Vietnam
Cultural Adaptation of the World Health Organization’s iSupport Dementia Program for Family Carers of People Living with Dementia in Vietnam Open
Introduction: Supporting carers is a key priority in the Global Action Plan on Dementia. The World Health Organization (WHO) developed iSupport, an online education and support program for family carers of people with dementia that can be …
View article: Hanoi Air Quantitative Report: A Cross-Sectional Study of Knowledge, Awareness, and Sustainable Practices Related to Air Pollution Among Residents of Hanoi, Vietnam
Hanoi Air Quantitative Report: A Cross-Sectional Study of Knowledge, Awareness, and Sustainable Practices Related to Air Pollution Among Residents of Hanoi, Vietnam Open
This study contributes to the broader sustainability discourse by evaluating public knowledge, awareness, and practices regarding air pollution among residents of Hanoi, Vietnam, focusing on its causes, health impacts, and mitigation strat…
View article: HARDMath2: A Benchmark for Applied Mathematics Built by Students as Part of a Graduate Class
HARDMath2: A Benchmark for Applied Mathematics Built by Students as Part of a Graduate Class Open
Large language models (LLMs) have shown remarkable progress in mathematical problem-solving, but evaluation has largely focused on problems that have exact analytical solutions or involve formal proofs, often overlooking approximation-base…
View article: Hanoi Air Quantitative Report: A Cross-Sectional Study of Knowledge, Awareness and Practices related to Air Pollution among Residents of Hanoi, Vietnam
Hanoi Air Quantitative Report: A Cross-Sectional Study of Knowledge, Awareness and Practices related to Air Pollution among Residents of Hanoi, Vietnam Open
The study on which this paper is based assessed public knowledge, awareness, and practices regarding air pollution among residents of Hanoi, Vietnam, focusing on its causes, health impacts, and mitigation strategies. It sought to provide e…
View article: Precise control of tibial nerve stimulation for bladder regulation via evoked compound action potential feedback mechanisms
Precise control of tibial nerve stimulation for bladder regulation via evoked compound action potential feedback mechanisms Open
Optimizing stimulation protocols for peripheral neuromodulation often depends on patient feedback, which can result in inconsistent clinical outcomes. Here we present a closed-loop control system for peripheral nerve stimulation (PNS) that…
View article: Precision Control of Tibial Nerve Stimulation for Bladder Regulation via Evoked Compound Action Potential Feedback Mechanisms
Precision Control of Tibial Nerve Stimulation for Bladder Regulation via Evoked Compound Action Potential Feedback Mechanisms Open
Optimizing stimulation protocols for peripheral neuromodulation often depends on patient feedback, which can result in inconsistent clinical outcomes. Here we present a closed-loop control system for peripheral nerve stimulation (PNS) that…
View article: Co-Targeting of DTYMK and PARP1 as a Potential Therapeutic Approach in Uveal Melanoma
Co-Targeting of DTYMK and PARP1 as a Potential Therapeutic Approach in Uveal Melanoma Open
Uveal melanoma (UM) is the most common primary intraocular tumor in adults, with no standardized treatment for advanced disease. Based on preliminary bioinformatical analyses DTYMK and PARP1 were selected as potential therapeutic targets. …
View article: Cutaneous Intravascular Hematolymphoid Entities: A Review
Cutaneous Intravascular Hematolymphoid Entities: A Review Open
Intravascular lymphomas are rare disease conditions that exhibit neoplastic lymphoid cells that are confined mainly to the lumens of small capillaries and medium-sized vessels. The majority of the intravascular lymphomas are of B-cell orig…
View article: Deep spatial context: when attention-based models meet spatial regression
Deep spatial context: when attention-based models meet spatial regression Open
We propose 'Deep spatial context' (DSCon) method, which serves for investigation of the attention-based vision models using the concept of spatial context. It was inspired by histopathologists, however, the method can be applied to various…
View article: SATB2, CKAE1/AE3, and synaptophysin as a sensitive immunohistochemical panel for the detection of lymph node metastases of Merkel cell carcinoma
SATB2, CKAE1/AE3, and synaptophysin as a sensitive immunohistochemical panel for the detection of lymph node metastases of Merkel cell carcinoma Open
Histopathological evaluation of lymph nodes in Merkel cell carcinoma has become crucial in progression estimation and treatment modification. This study was undertaken to determine the most sensitive immunohistochemical panel for detecting…
View article: Ki67 is a better marker than PRAME in risk stratification of BAP1-positive and BAP1-loss uveal melanomas
Ki67 is a better marker than PRAME in risk stratification of BAP1-positive and BAP1-loss uveal melanomas Open
Background Accurate risk stratification of uveal melanoma (UM) patients is important for determining the interval and frequency of surveillance. Loss of BAP1 expression has been shown to be strongly associated with UM-related death and met…
View article: Combinations of EGFR and MET inhibitors reduce proliferation and invasiveness of mucosal melanoma cells
Combinations of EGFR and MET inhibitors reduce proliferation and invasiveness of mucosal melanoma cells Open
Mucosal melanoma (MM) is a very rare and aggressive type of cancer for which immunotherapy or targeted therapy such as BRAF/MEK inhibitors, used in cutaneous melanoma, usually fail. Due to our earlier experience showing the high effectiven…
View article: Sweet syndrome following routine orthopedic surgeries: A case series of 7 patients with surgical rechallenges
Sweet syndrome following routine orthopedic surgeries: A case series of 7 patients with surgical rechallenges Open
Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is characterized by the abrupt onset of edematous, erythematous to violaceous plaques, fever, leukocytosis, and dense neutrophilic infiltrate on histopathology. Patients experi…
View article: Epidermolysis bullosa acquisita following skin graft in donor and graft sites: A case report
Epidermolysis bullosa acquisita following skin graft in donor and graft sites: A case report Open
Epidermolysis bullosa acquisita is a rare mucocutaneous autoimmune blistering disorder which usually presents in adulthood. The disease is mediated by antibodies against type VII collagen, though the precise inciting factors for autoantibo…
View article: Prognostic biomarkers for survival in mucosal melanoma
Prognostic biomarkers for survival in mucosal melanoma Open
Mucosal melanoma (MM) is a rare subtype of melanoma with an aggressive clinical course. In cutaneous melanoma (CM), the absence of pigmentation and presence of NRAS/KRAS mutations are biomarkers indicating an aggressive clinical course wit…
View article: Supplementary Data from <i>Ex Vivo</i> Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids
Supplementary Data from <i>Ex Vivo</i> Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids Open
Supplementary Figure Legends and Figures
View article: Supplementary Methods, Figures S1 - S20 from Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
Supplementary Methods, Figures S1 - S20 from Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets Open
Supplementary Methods, Figures S1 - S20. Figure S1. Branched evolution leads to tissue-sampling bias in primary tumor samples. Figure S2. Results of ABSOLUTE on samples from patient 418. Figure S3. 2D Bayesian clustering analysis of point-…
View article: Table S4 from <i>Ex Vivo</i> Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids
Table S4 from <i>Ex Vivo</i> Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids Open
TCGA Source Data
View article: Supp. Movie 1 from <i>Ex Vivo</i> Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids
Supp. Movie 1 from <i>Ex Vivo</i> Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids Open
PDOTS Movie
View article: Supplementary Table S3 from Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
Supplementary Table S3 from Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets Open
Summary of clinically informative (TARGET) genes.
View article: Supplementary File 3 from Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
Supplementary File 3 from Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets Open
Supplementary File 3. Detailed plots of the data used for phylogenetic inference in each case. The description for the plots in Supplementary File 3 can be found in the Legend of Supplementary Figure S13-S17.