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View article: Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma
Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma Open
Leptomeningeal metastasis remains a difficult clinical challenge. Some success has been achieved by direct administration of therapeutics into the cerebrospinal fluid (CSF) circumventing limitations imposed by the blood brain barrier. Here…