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Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice: antidepressant effects beyond the brain Open

Mylène Fefeu, Michael Blatzer, Anita Kneppers, David Briand, Pierre Rocheteau , et al. · 2025

Introduction Fluoxetine, the first selective serotonin reuptake inhibitor, is the world’s most prescribed antidepressant. Several mechanisms of action underpin the effect of this antidepressant, such as enhancing serotonin (5-HT) neurotran…

Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice Open

Mylène Fefeu, Michael Blatzer, Anita Kneppers, David Briand, Pierre Rocheteau , et al. · 2024

Elevated Effort Cost Identified by Computational Modeling as a Distinctive Feature Explaining Multiple Behaviors in Patients With Depression Open

Fabien Vinckier, Claire Jaffré, Claire Gauthier, Sarah Smajda, Pierre Abdel-Ahad , et al. · 2022

These results highlight effort cost as a critical dimension that might explain multiple behavioral changes in patients with depression. More generally, they validate a test battery for computational phenotyping of motivational states, whic…

Effects of fluoxetine, a serotonin reuptake inhibitor, on muscle stem cells and muscle regeneration Open

Mylène Fefeu · 2021

Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration Open

David Hardy, Mylène Fefeu, Aurore Besnard, David Briand, Paméla Gasse , et al. · 2019

MOESM5 of Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration Open

David Hardy, Mylène Fefeu, Aurore Besnard, David Briand, Paméla Gasse , et al. · 2019

Additional file 5: Figure S4. (Related to Figure 3). Quantitative histological and cytometric parameters of the muscle one month post NTX injury in the WT and the CXCL12Gagtm/Gagtm mice. (A) Quantification of calcium deposits number by Von…

MOESM7 of Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration Open

David Hardy, Mylène Fefeu, Aurore Besnard, David Briand, Paméla Gasse , et al. · 2019

Additional file 7: Figure S6. (Related to Figure 5). Quantitative histological and ultrastructure parameters of the vascular network of muscle one month post FI in WT and KI mice. (A) Quantification of the sprouting vessels number one mont…

MOESM3 of Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration Open

David Hardy, Mylène Fefeu, Aurore Besnard, David Briand, Paméla Gasse , et al. · 2019

Additional file 3: Figure S2. (Related to Figure 2). CXCL12gagtm/gagtm and WT satellite cells show identical behavior. (A) Heat map of the three most up- and down-regulated genes identified by the genome-wide microarray analysis on FACS-so…

MOESM4 of Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration Open

David Hardy, Mylène Fefeu, Aurore Besnard, David Briand, Paméla Gasse , et al. · 2019

Additional file 4: Figure S3. (Related to Figure 2). KI ECs display an increased angiogenic response. (A) Heat map of the three most up- and down-regulated genes identified by the genome-wide microarray analysis on FACS-sorted ECs from the…

MOESM2 of Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration Open

David Hardy, Mylène Fefeu, Aurore Besnard, David Briand, Paméla Gasse , et al. · 2019

Additional file 2: Figure S1. (Related to Figure 1). Quantitative histological and cytometric parameters of the resting muscle from WT and CXCL12Gagtm/Gagtm mice. Quantification of (A) fibers number and (B) fibers diameter by Hematoxylin-e…

MOESM1 of Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration Open

David Hardy, Mylène Fefeu, Aurore Besnard, David Briand, Paméla Gasse , et al. · 2019

Additional file 1: Table S1. Oligonucleotide primers for RTqPCR, Related to Figures 5, S2, S3.

MOESM6 of Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration Open

David Hardy, Mylène Fefeu, Aurore Besnard, David Briand, Paméla Gasse , et al. · 2019

Additional file 6: Figure S5. (Related to Figure 4). Quantitative histological and cytometric parameters of the muscle one month post FI in WT and CXCL12Gagtm/Gagtm mice. RTqPCR gene expression in FACS-sorted MPs, FAPs, SCs, ECs from TA mu…

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