Myra Guo
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View article: Evaluation of immune responses to Tdap booster during pregnancy in women who received whole cell or acellular pertussis vaccines during childhood
Evaluation of immune responses to Tdap booster during pregnancy in women who received whole cell or acellular pertussis vaccines during childhood Open
Pertussis, caused by Bordetella pertussis (Bp), results in severe morbidity and mortality in infants. Since 2012, the tetanus, diphtheria and pertussis (Tdap) booster vaccine is recommended during every pregnancy to protect infants who are…
View article: The adjuvant BcfA activates antigen presenting cells through TLR4 and supports TFH and TH1 while attenuating TH2 gene programming
The adjuvant BcfA activates antigen presenting cells through TLR4 and supports TFH and TH1 while attenuating TH2 gene programming Open
Introduction Adjuvants added to subunit vaccines augment antigen-specific immune responses. One mechanism of adjuvant action is activation of pattern recognition receptors (PRRs) on innate immune cells. Bordetella colonization factor A (Bc…
View article: Opposing effects of acellular and whole cell pertussis vaccines on<i>Bordetella pertussis</i>biofilm formation, Siglec-F+ neutrophil recruitment and bacterial clearance in mouse nasal tissues
Opposing effects of acellular and whole cell pertussis vaccines on<i>Bordetella pertussis</i>biofilm formation, Siglec-F+ neutrophil recruitment and bacterial clearance in mouse nasal tissues Open
Despite global vaccination, pertussis caused by Bordetella pertussis ( Bp ) is resurging. Pertussis resurgence is correlated with the switch from whole cell vaccines (wPV) that elicit T H 1/T H 17 polarized immune responses to acellular pe…
View article: Systemic priming and intranasal booster with a BcfA-adjuvanted acellular pertussis vaccine generates CD4+ IL-17+ nasal tissue resident T cells and reduces B. pertussis nasal colonization
Systemic priming and intranasal booster with a BcfA-adjuvanted acellular pertussis vaccine generates CD4+ IL-17+ nasal tissue resident T cells and reduces B. pertussis nasal colonization Open
Introduction Resurgence of pertussis, caused by Bordetella pertussis, necessitates novel vaccines and vaccination strategies to combat this disease. Alum-adjuvanted acellular pertussis vaccines (aPV) delivered intramuscularly reduce bacter…