Joon Sig Choi
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View article: Crystal structures of the μ2 subunit of clathrin-adaptor protein 2 in complex with peptides derived from human papillomavirus 16 E7
Crystal structures of the μ2 subunit of clathrin-adaptor protein 2 in complex with peptides derived from human papillomavirus 16 E7 Open
Human papillomaviruses (HPVs) cause abnormal cellular proliferation, leading to malignant or benign lesions, such as cervical cancer and warts. The genome of HPV16, the most prevalent high-risk oncogenic genotype within the Alphapapillomav…
View article: Exosome-membrane and polymer-based hybrid-complex for systemic delivery of plasmid DNA into brains for the treatment of glioblastoma
Exosome-membrane and polymer-based hybrid-complex for systemic delivery of plasmid DNA into brains for the treatment of glioblastoma Open
View article: Development of a Power Generation Forecast Model that Reflects the Degradation Conditions of Solar Modules: For AI Technique Approach
Development of a Power Generation Forecast Model that Reflects the Degradation Conditions of Solar Modules: For AI Technique Approach Open
View article: Second-Generation Polyamidoamine Dendrimer Conjugated with Oligopeptides Can Enhance Plasmid DNA Delivery In Vitro
Second-Generation Polyamidoamine Dendrimer Conjugated with Oligopeptides Can Enhance Plasmid DNA Delivery In Vitro Open
Poly(amidoamine) (PAMAM) dendrimers have attracted considerable attention in the field of gene therapy due to their flexibility in introducing different functional moieties and reduced toxicity at low generations. However, their transfecti…
View article: Crystal structure of Bak bound to the <scp>BH3</scp> domain of Bnip5, a noncanonical <scp>BH3</scp> domain‐containing protein
Crystal structure of Bak bound to the <span>BH3</span> domain of Bnip5, a noncanonical <span>BH3</span> domain‐containing protein Open
The activation or inactivation of B‐cell lymphoma‐2 (Bcl‐2) antagonist/killer (Bak) is critical for controlling mitochondrial outer membrane permeabilization‐dependent apoptosis. Its pro‐apoptotic activity is controlled by intermolecular i…
View article: Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1
Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1 Open
Bak is a critical executor of apoptosis belonging to the Bcl-2 protein family. Bak contains a hydrophobic groove where the BH3 domain of proapoptotic Bcl-2 family members can be accommodated, which initiates its activation. Once activated,…
View article: Conjugation of Short Oligopeptides to a Second-Generation Polyamidoamine Dendrimer Shows Antibacterial Activity
Conjugation of Short Oligopeptides to a Second-Generation Polyamidoamine Dendrimer Shows Antibacterial Activity Open
The growing evolution of bacterial resistance to antibiotics represents a global issue that not only impacts healthcare systems but also political and economic processes. This necessitates the development of novel antibacterial agents. Ant…
View article: Nanoemulsion Composed of α-Tocopherol Succinate and Dequalinium Shows Mitochondria-Targeting and Anticancer Effects
Nanoemulsion Composed of α-Tocopherol Succinate and Dequalinium Shows Mitochondria-Targeting and Anticancer Effects Open
Targeted drugs have been used to treat mitochondrial dysfunction-related diseases, including metabolic disorders and cancer; however, targeting and penetrating intracellular organelles remains a challenge. Dominant targeting approaches for…
View article: Structural and biochemical analyses of Bcl-xL in complex with the BH3 domain of peroxisomal testis-specific 1
Structural and biochemical analyses of Bcl-xL in complex with the BH3 domain of peroxisomal testis-specific 1 Open
Antiapoptotic B-cell lymphoma-2 (Bcl-2) proteins suppress apoptosis by interacting with proapoptotic regulators. They commonly contain a hydrophobic groove where the Bcl-2 homology 3 (BH3) domain of Bcl-2 family members or BH3 domain-conta…
View article: Enzyme-Responsive Amphiphilic Peptide Nanoparticles for Biocompatible and Efficient Drug Delivery
Enzyme-Responsive Amphiphilic Peptide Nanoparticles for Biocompatible and Efficient Drug Delivery Open
Self-assembled peptide nanostructures recently have gained much attention as drug delivery systems. As biomolecules, peptides have enhanced biocompatibility and biodegradability compared to polymer-based carriers. We introduce a peptide na…
View article: Apoptin gene delivery by a PAMAM dendrimer modified with a nuclear localization signal peptide as a gene carrier for brain cancer therapy
Apoptin gene delivery by a PAMAM dendrimer modified with a nuclear localization signal peptide as a gene carrier for brain cancer therapy Open
In this study, we aimed to synthesize PAMAMG3 derivatives (PAMAMG3-KRRR and PAMAMG3-HKRRR), using KRRR peptides as a nuclear localization signal and introduced histidine residues into the KRRR-grafted PAMAMG3 for delivering a therapeutic, …
View article: Cathepsin B-Responsive Liposomes for Controlled Anticancer Drug Delivery in Hep G2 Cells
Cathepsin B-Responsive Liposomes for Controlled Anticancer Drug Delivery in Hep G2 Cells Open
In recent decades, several types of anticancer drugs that inhibit cancer cell growth and cause cell death have been developed for chemotherapeutic application. However, these agents are usually associated with side effects resulting from n…
View article: Comparison of lipid profiles in head and brain samples of drosophila melanogaster using electrospray ionization mass spectrometry (ESI-MS)
Comparison of lipid profiles in head and brain samples of drosophila melanogaster using electrospray ionization mass spectrometry (ESI-MS) Open
Drosophila melanogaster (fruits fly) is a representative model system widely used in biological studies because its\nbrain function and basic cellular processes are similar to human beings. The whole head of the fly is often used to obtain…
View article: Polyplexes of Functional PAMAM Dendrimer/Apoptin Gene Induce Apoptosis of Human Primary Glioma Cells In Vitro
Polyplexes of Functional PAMAM Dendrimer/Apoptin Gene Induce Apoptosis of Human Primary Glioma Cells In Vitro Open
Highly efficient and safe gene delivery has become an important aspect of neuronal gene therapy. We evaluated the ability of polyamidoamine (PAMAM) dendrimer grafted with phenylalanine, histidine, and arginine (PAMAM-FHR), a nonviral gene …
View article: Gold nanorods-conjugated TiO2 nanoclusters for the synergistic combination of phototherapeutic treatments of cancer cells
Gold nanorods-conjugated TiO2 nanoclusters for the synergistic combination of phototherapeutic treatments of cancer cells Open
View article: Polyamidoamine (PAMAM) Dendrimers Modified with Cathepsin-B Cleavable Oligopeptides for Enhanced Gene Delivery
Polyamidoamine (PAMAM) Dendrimers Modified with Cathepsin-B Cleavable Oligopeptides for Enhanced Gene Delivery Open
Because of the complex mechanisms mediating cancer onset, prognosis, and metastatic behavior, different therapeutic approaches targeting these mechanisms have been investigated. Recent advancements in nanocarrier-based drug and gene delive…
View article: Apoptin Gene Delivery by the Functionalized Polyamidoamine (PAMAM) Dendrimer Modified with Ornithine Induces Cell Death of HepG2 Cells
Apoptin Gene Delivery by the Functionalized Polyamidoamine (PAMAM) Dendrimer Modified with Ornithine Induces Cell Death of HepG2 Cells Open
The use of tumor-specific therapeutic agents is a promising option for efficient and safe nonviral gene transfer in gene therapy. In this study, we describe the efficacy of polyamidoamine (PAMAM)-based nonviral gene delivery carriers, name…
View article: Antibacterial Films: Mussel‐Inspired Approach to Constructing Robust Multilayered Alginate Films for Antibacterial Applications (Adv. Funct. Mater. 23/2016)
Antibacterial Films: Mussel‐Inspired Approach to Constructing Robust Multilayered Alginate Films for Antibacterial Applications (Adv. Funct. Mater. 23/2016) Open
A novel method for generating a multilayered alginate film by mimicking the special properties of mussels was developed by J. S. Choi, W. K. Cho, S. M. Kang, and co-workers, as described on page 4099. Generated multilayered alginate films …
View article: Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0
Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0 Open
EGFR is a key player in cell proliferation and survival signaling, and its sorting into MVBs for eventual lysosomal degradation is controlled by the coordination of multiple ESCRT complexes on the endosomal membrane. HD-PTP is a cytosolic …
View article: Multi-dimensional TOF-SIMS analysis for effective profiling of disease-related ions from the tissue surface
Multi-dimensional TOF-SIMS analysis for effective profiling of disease-related ions from the tissue surface Open