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View article: Linking multicenter electronic health records with socioeconomic data to examine receipt of standard versus premium intraocular lenses
Linking multicenter electronic health records with socioeconomic data to examine receipt of standard versus premium intraocular lenses Open
Purpose: Premium intraocular lenses (IOLs) can improve visual outcomes and reduce dependence on glasses but often require out-of-pocket payment. The socioeconomic factors influencing their selection remain poorly understood. Leveraging a m…
View article: Quality of Care in Patients With Newly Diagnosed Glaucoma
Quality of Care in Patients With Newly Diagnosed Glaucoma Open
Importance Various communities continue to experience relatively high rates of glaucoma-related visual impairment and blindness. Identifying potential nonmedical influences on glaucoma outcomes may lead to strategies to improve glaucoma ca…
View article: Critical temperature thresholds for identifying vulnerability to heat-related excess cardiovascular morbidity and mortality
Critical temperature thresholds for identifying vulnerability to heat-related excess cardiovascular morbidity and mortality Open
Background Extreme heat is a known environmental hazard linked to increased cardiovascular disease (CVD) morbidity and mortality, yet most studies fail to evaluate both acute and long-term effects. We assessed heat-related CVD, and its sub…
View article: Preoperative Factors Associated With Falls Following Total Hip Arthroplasty in Older Adults
Preoperative Factors Associated With Falls Following Total Hip Arthroplasty in Older Adults Open
Objective Falls are common after total hip arthroplasty (THA) and can cause serious complications. Understanding preoperative factors linked to falls post‐THA can inform discharge planning and management to lower fall risk. We aimed to ide…
View article: Evaluating the Performance and Potential Bias of Predictive Models for Detection of Transthyretin Cardiac Amyloidosis
Evaluating the Performance and Potential Bias of Predictive Models for Detection of Transthyretin Cardiac Amyloidosis Open
Deep learning, echo-based models to detect ATTR-CM demonstrated best overall discrimination when compared to 2 other models in external validation with low risk of harms due to racial bias.
View article: Barriers and Facilitators to Heart Failure Guideline-Directed Medical Therapy in an Integrated Health System and Federally Qualified Health Centers: A Thematic Qualitative Analysis
Barriers and Facilitators to Heart Failure Guideline-Directed Medical Therapy in an Integrated Health System and Federally Qualified Health Centers: A Thematic Qualitative Analysis Open
Background Clinical guidelines recommend medications from four drug classes, collectively referred to as quadruple therapy, to improve outcomes for patients with heart failure with reduced ejection fraction (HFrEF). Wide gaps in uptake of …
View article: Daily Heart Rate per Step: A Wearables Metric Associated With Cardiovascular Disease in a Cross‐Sectional Study of the <i>All of Us</i> Research Program
Daily Heart Rate per Step: A Wearables Metric Associated With Cardiovascular Disease in a Cross‐Sectional Study of the <i>All of Us</i> Research Program Open
Background Simple biometrics such as peak heart rate and exercise duration remain core predictors of cardiovascular disease (CVD). Commercial wearable devices track physical and cardiac electrical activity. Detailed, longitudinal data coll…
View article: The Association of Social Determinants of Health on Monitoring for Disease Progression Among Patients With Primary Open-Angle Glaucoma
The Association of Social Determinants of Health on Monitoring for Disease Progression Among Patients With Primary Open-Angle Glaucoma Open
This study aimed to determine the association between SDH and receiving POAG testing according to clinical practice guidelines, with a goal of identifying factors contributing to disparities in care. This should facilitate development of t…
View article: Change in address in electronic health records as an early marker of homelessness
Change in address in electronic health records as an early marker of homelessness Open
Introduction Housing stability is a key health determinant and there is a need for early screening for instability with existing electronic health record (EHR) data to improve health outcomes. We aim to establish recorded address changes a…
View article: Data linkage multiplies research insights across diverse healthcare sectors
Data linkage multiplies research insights across diverse healthcare sectors Open
In all fields of study, as well as government and commerce, high-quality data enables informed decision-making. Linking data from disparate sources multiplies the opportunities for novel insights and evidence-based decision-making for an i…
View article: Cohort study examining social determinants of health and their association with mortality among hospitalised adults in New York and California
Cohort study examining social determinants of health and their association with mortality among hospitalised adults in New York and California Open
Background Adults in the US face significant disparities in health as a result of the social determinants of health (SDOH). While the link between SDOH and mortality is well-established, their impact on outcomes after hospitalisation is le…
View article: Barriers and Facilitators to Heart Failure Guideline-Directed Medical Therapy in an Integrated Health System and Federally-Qualified Health Centers: A Thematic Qualitative Analysis
Barriers and Facilitators to Heart Failure Guideline-Directed Medical Therapy in an Integrated Health System and Federally-Qualified Health Centers: A Thematic Qualitative Analysis Open
Background Clinical guidelines recommend medications from four drug classes, collectively referred to as quadruple therapy, to improve outcomes for patients with heart failure with reduced ejection fraction (HFrEF). Wide gaps in uptake of …
View article: Contextual factors and implementation strategies for a multi-level community-based sodium reduction intervention in Chicago’s South Side: A qualitative study
Contextual factors and implementation strategies for a multi-level community-based sodium reduction intervention in Chicago’s South Side: A qualitative study Open
Background Excessive sodium intake exacerbates rates of hypertension. African American adults have higher rates of hypertension in part due to a higher-sodium diet. The multi-level Communication for Behavioral Impact for Sodium Reduction (…
View article: Evaluating the performance and potential bias of predictive models for detection of transthyretin cardiac amyloidosis
Evaluating the performance and potential bias of predictive models for detection of transthyretin cardiac amyloidosis Open
Background Delays in the diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) contribute to the significant morbidity of the condition, especially in the era of disease-modifying therapies. Screening for ATTR-CM with AI and other al…
View article: Race, Social Determinants of Health, and the Quality of Diabetic Eye Care
Race, Social Determinants of Health, and the Quality of Diabetic Eye Care Open
Importance Besides race, little is known about how other social determinants of health (SDOH) affect quality of diabetic eye care. Objective To evaluate the association between multiple SDOH and monitoring for diabetic retinopathy (DR) in …
View article: Methodological Approaches for Measuring the Association Between Heat Exposure and Health Outcomes: A Comprehensive Global Scoping Review
Methodological Approaches for Measuring the Association Between Heat Exposure and Health Outcomes: A Comprehensive Global Scoping Review Open
Objective: To synthesize the methodologies of studies that evaluate the impacts of heat exposure on morbidity and mortality. Methods: Embase, MEDLINE, Web of Science, and Scopus were searched from date of inception until 1 March 2023 for E…
View article: Northwestern University resource and education development initiatives to advance collaborative artificial intelligence across the learning health system
Northwestern University resource and education development initiatives to advance collaborative artificial intelligence across the learning health system Open
Introduction The rapid development of artificial intelligence (AI) in healthcare has exposed the unmet need for growing a multidisciplinary workforce that can collaborate effectively in the learning health systems. Maximizing the synergy a…
View article: Rapid identification of inflammatory arthritis and associated adverse events following immune checkpoint therapy: a machine learning approach
Rapid identification of inflammatory arthritis and associated adverse events following immune checkpoint therapy: a machine learning approach Open
Introduction Immune checkpoint inhibitor-induced inflammatory arthritis (ICI-IA) poses a major clinical challenge to ICI therapy for cancer, with 13% of cases halting ICI therapy and ICI-IA being difficult to identify for timely referral t…
View article: Natural language processing to identify lupus nephritis phenotype in electronic health records
Natural language processing to identify lupus nephritis phenotype in electronic health records Open
Background Systemic lupus erythematosus (SLE) is a rare autoimmune disorder characterized by an unpredictable course of flares and remission with diverse manifestations. Lupus nephritis, one of the major disease manifestations of SLE for o…
View article: The National Heart Lung and Blood Institute Disparities Elimination through Coordinated Interventions to Prevent and Control Heart and Lung Disease Alliance
The National Heart Lung and Blood Institute Disparities Elimination through Coordinated Interventions to Prevent and Control Heart and Lung Disease Alliance Open
Objective: To describe the National Heart Lung and Blood Institute (NHLBI) sponsored Disparities Elimination through Coordinated Interventions to Prevent and Control Heart and Lung Disease (DECIPHeR) Alliance to support late-stage implemen…
View article: Privacy‐preserving record linkage across disparate institutions and datasets to enable a learning health system: The national <scp>COVID</scp> cohort collaborative (<scp>N3C</scp>) experience
Privacy‐preserving record linkage across disparate institutions and datasets to enable a learning health system: The national <span>COVID</span> cohort collaborative (<span>N3C</span>) experience Open
Introduction Research driven by real‐world clinical data is increasingly vital to enabling learning health systems, but integrating such data from across disparate health systems is challenging. As part of the NCATS National COVID Cohort C…
View article: Process of Engaging Community and Scientific Partners in the Development of the CIRCL-Chicago Study Protocol
Process of Engaging Community and Scientific Partners in the Development of the CIRCL-Chicago Study Protocol Open
Objectives Hypertension affects 1 in 3 adults in the United States and disproportionately affects African Americans. Kaiser Permanente demonstrated that a “bundle” of evidence-based interventions significantly increased blood pressure cont…