Óscar Arias-Carrión
YOU?
Author Swipe
Overexpression of ITGB3 in Peripheral Blood Mononuclear Cells of Relapsing-Remitting Multiple Sclerosis Patients Open
Multiple sclerosis (MS), the most prevalent chronic inflammatory, demyelinating and neurodegenerative disease of the central nervous system in young adults, exhibits marked sexual dimorphism, with a 3:1 female-to-male ratio, but more sever…
Treatment strategies for motor fluctuations in Parkinson’s disease: a systematic review of efficacy, functionality, and drug accessibility with a focus on Latin America Open
Background Motor fluctuations represent a major therapeutic challenge in Parkinson’s disease, particularly among individuals on long-term levodopa therapy. Although diverse pharmacological and device-aided strategies are available, their c…
Neuroscience of Behavior Open
Behavior is not a mere sequence of responses to stimuli but the dynamic expression of internal processes such as planning, prediction, valuation, and inference. These functions arise from distributed and metabolically costly neural systems…
Animal Models of Narcolepsy: From Orexin Deficiency to Immune Mechanisms and Regenerative Therapies Open
Animal models have been pivotal in uncovering the orexin (hypocretin) system as the fulcrum of sleep–wake regulation and in shaping therapeutic discovery for narcolepsy. Early canine and murine models established that orexin loss underlies…
Toward Biology-Driven Diagnosis of Atypical Parkinsonian Disorders Open
Atypical parkinsonian disorders—progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and multiple system atrophy (MSA)—are rare, rapidly progressive neurodegenerative syndromes characterized by distinct molecular patholog…
Decoding the structural and functional diversity of GABAA receptors: from ensemble logic to therapeutic opportunities Open
GABA A receptors (GABA A Rs) are no longer viewed as uniform inhibitory switches but as structurally diverse, dynamically regulated ensembles that decode inhibitory signals with remarkable spatial and temporal precision. Their heterogeneit…
View article: Aurora: a mobile-based cognitive behavioral therapy intervention for anxiety and depression in Mexico
Aurora: a mobile-based cognitive behavioral therapy intervention for anxiety and depression in Mexico Open
Background Anxiety and depression are leading contributors to disability worldwide. In Mexico, an upper-middle-income country (UMIC) with health-system constraints resembling those of low- and middle-income countries (LMICs), access to psy…
Animal Models of Narcolepsy: From Hypocretin Deficiency to Immune Mechanisms and Regenerative Therapies Open
Animal models have been pivotal in uncovering the hypocretin (orexin) system as the fulcrum of sleep–wake regulation and in shaping therapeutic discovery for narcolepsy. Early canine and murine models established that hypocretin loss under…
Conscious breathing enhances bidirectional cortical-autonomic modulation: dynamics of EEG band power and heart rate variability Open
Introduction The mechanisms by which conscious breathing influences brain-body signaling remain largely unexplored. Understanding how controlled breathing modulates neural and autonomic activity can offer insights into self-regulation and …
Pharmacokinetics and safety of a fixed-dose combination of pregabalin and thioctic acid in healthy volunteers: a randomized, open-label, phase 1 crossover study Open
Background Pregabalin (PGB) is a first-line therapy for painful diabetic neuropathy (PDN), but its adverse effects limit use. Thioctic acid, also known as α-lipoic acid (ALA), exhibits antioxidant and neuroprotective properties. The pharma…
View article: Sex-Specific Association Between XPC rs2228001 Polymorphism and Parkinson’s Disease Risk in a Mexican Population: A Case–Control Study Exploring Gene–Environment Interactions
Sex-Specific Association Between XPC rs2228001 Polymorphism and Parkinson’s Disease Risk in a Mexican Population: A Case–Control Study Exploring Gene–Environment Interactions Open
Background/Objectives: Emerging evidence implicates impaired DNA repair mechanisms in the pathogenesis of Parkinson’s disease (PD), particularly in the context of oxidative stress and environmental exposures. This study investigated the as…
Precision Diagnostic Strategies for Atypical Parkinsonian Disorders Open
Atypical parkinsonian disorders—progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and multiple system atrophy (MSA)—are rare, rapidly progressive neurodegenerative syndromes with complex clinical presentations, distinc…
Elevated Mean Corpuscular Hemoglobin Concentration as a Potential Peripheral Biomarker of Parkinson’s Disease: A Pilot Case–Control Study in a Mexican Population Open
Background: Alterations in peripheral red blood cell (RBC) indices have been proposed as potential biomarkers for Parkinson’s disease (PD), but their diagnostic utility and relation to clinical features remain uncertain. Methods: We conduc…
Synergistic antiallodynic effects of pregabalin and thioctic acid in a rat model of neuropathic pain Open
Background Neuropathic pain is a chronic and often disabling condition that remains refractory to monotherapy because of limited efficacy and dose-limiting adverse effects. Combination therapies that engage complementary mechanisms of acti…
Tremor: Clinical Frameworks, Network Dysfunction and Therapeutics Open
Background: Tremor is a common but diagnostically challenging movement disorder due to its clinical heterogeneity and overlapping aetiologies. The 2018 consensus introduced a two-axis classification system that redefined tremor syndromes b…
Brain–Computer Interfaces in Parkinson’s Disease Rehabilitation Open
Parkinson’s disease (PD) is a progressive neurological disorder with motor and non-motor symptoms that are inadequately addressed by current pharmacological and surgical therapies. Brain–computer interfaces (BCIs), particularly those based…
Translating Exosomal microRNAs from Bench to Bedside in Parkinson’s Disease Open
Parkinson’s disease (PD) is a progressive neurodegenerative disorder marked by dopaminergic neuronal loss, α-synuclein aggregation, and chronic neuroinflammation. Recent evidence suggests that exosomal microRNAs (miRNAs)—small, non-coding …
Differential methylation of SNCA and MAPT genes associated with Parkinson’s disease in Mexican Mestizos Open
Introduction Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rigidity, and tremor. Despite its prevalence, genetic and epigenetic studies in the Mexican Mestizo population (ind…
Artificial Intelligence in Systematic Reviews: Overcoming Reproducibility, Bias and Validation Challenges Open
Artificial Intelligence (AI) is rapidly changing how systematic reviews are conducted by accelerating the processes of literature retrieval and screening. While these ad-vancements enhance researchers’ productivity, the complete scope of A…
The ReHand-BCI trial: a randomized controlled trial of a brain-computer interface for upper extremity stroke neurorehabilitation Open
Background Brain-computer interfaces (BCI) are a promising complementary therapy for stroke rehabilitation due to the close-loop feedback that can be provided with these systems, but more evidence is needed regarding their clinical and neu…
α-Synuclein Pathology in Synucleinopathies: Mechanisms, Biomarkers, and Therapeutic Challenges Open
Parkinson’s disease and related synucleinopathies, including dementia with Lewy bodies and multiple system atrophy, are characterised by the pathological aggregation of the α-synuclein (aSyn) protein in neuronal and glial cells, leading to…
View article: Functional Movement Disorder: Evolving Mechanisms, Diagnostic Precision, and Personalized Multidisciplinary Care
Functional Movement Disorder: Evolving Mechanisms, Diagnostic Precision, and Personalized Multidisciplinary Care Open
Background Functional movement disorder (FMD) is a neuropsychiatric condition characterized by involuntary motor symptoms that are inconsistent with known neurological diseases and linked to dysfunction in brain networks involved in motor …
Longitudinal Dynamics of Clinical and Neurophysiological Changes in Parkinson's Disease: A 4.5-Year Cohort Study Open
Parkinson's disease (PD) is characterized by progressive motor and non-motor symptoms, yet the longitudinal interplay between clinical progression and neurophysiological alterations remains underexplored. In this four-and-a-half-year longi…
Redefining Non-Motor Symptoms in Parkinson’s Disease Open
Parkinson’s disease involves widespread neurodegeneration that extends far beyond the basal ganglia, giving rise to a diverse range of non-motor symptoms that frequently emerge before motor onset. These include autonomic dysfunction, cogni…
α-Synuclein Pathology in Synucleinopathies: Mechanisms, Biomarkers, and Therapeutic Challenges Open
Parkinson's disease and related synucleinopathies, including dementia with Lewy bodies and multiple system atrophy, are characterized by the pathological aggregation of the α-synuclein (aSyn) protein in neuronal and glial cells, leading to…
α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies Open
Neurodegenerative diseases are characterized by protein aggregation and overlapping pathologies, challenging traditional classifications and highlighting shared underlying mechanisms. Parkinson’s disease and related synucleinopathies, incl…
Non-Motor Symptoms in Parkinson’s Disease Open
Parkinson’s disease encompasses a spectrum of motor and non-motor manifestations, with the latter often preceding motor symptoms and influencing disease trajectory. Sensory dysfunction, sleep-related disorders, autonomic impairment, neurop…
Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders Open
Advanced magnetic resonance imaging (MRI) techniques are transforming the study of movement disorders by providing valuable insights into disease mechanisms. This narrative review presents a comprehensive overview of their applications in …
Advanced MRI in Movement Disorders: A Promising Tool for Early Diagnosis and Monitoring Disease Progression Open
Advanced magnetic resonance imaging (MRI) techniques are transforming the study of movement disorders, offering unprecedented opportunities for early diagnosis, disease monitoring, and therapeutic evaluation. Emerging modalities such as ne…