Noorjahan Banu Alitheen
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View article: Synthesis of CNP-SAR405 delivery system for improved therapeutics anticancer activity using A549 human lung cancer cell lines
Synthesis of CNP-SAR405 delivery system for improved therapeutics anticancer activity using A549 human lung cancer cell lines Open
Autophagy, a critical homeostatic process, is increasingly implicated in cancer progression and therapy resistance. SAR405 is a potent inhibitor of the autophagy related PIK3C3/VPS34 complex, offering potential as an anticancer agent. This…
View article: ExRNA as theranostic agents in cancer: current progress and future perspectives
ExRNA as theranostic agents in cancer: current progress and future perspectives Open
View article: Comparative analysis of microbial diversity in various kombucha starter cultures in Malaysia using the random amplified polymorphic DNA (RAPD) approach
Comparative analysis of microbial diversity in various kombucha starter cultures in Malaysia using the random amplified polymorphic DNA (RAPD) approach Open
Kombucha is sweetened black tea fermented with symbiotic culture of bacteria and yeasts (SCOBY) and has been widely consumed for its purported health benefits. The microbial consortium in kombucha is dominated by yeasts such as Brettanomyc…
View article: Determination of the Pathogenicity of the Variant UPM 1432/2019 IBDV in SPF Chicken Eggs and Chicken Fibroblast Cell Line
Determination of the Pathogenicity of the Variant UPM 1432/2019 IBDV in SPF Chicken Eggs and Chicken Fibroblast Cell Line Open
The infectious bursal disease virus (IBDV) is a nuisance to chicken productivity in the global poultry industry due to its high pathogenicity. In this study, the pathogenicity of the UPM 1432/2019 variant was evaluated using specific patho…
View article: Synthesis and Characterization of 5-Fluoroacil Loaded Calcium Carbonate Nanoparticles for Targeted Cancer Therapy
Synthesis and Characterization of 5-Fluoroacil Loaded Calcium Carbonate Nanoparticles for Targeted Cancer Therapy Open
Chemotherapy is often limited by its systemic toxicity and lack of specificity, necessitating the development of targeted drug delivery systems that can enhance therapeutic efficacy while minimizing adverse effects. Addressing this, our s…
View article: Screening of microbial population in Sabah tea kombucha pellicle for its potential as prebiotic and probiotic supplement
Screening of microbial population in Sabah tea kombucha pellicle for its potential as prebiotic and probiotic supplement Open
This research aimed to determine and analyze the microbial population in kombucha pellicles derived from Sabah black tea, specifically focusing on bacteria and yeast, to gain insights into their abundance, diversity, and potential as prebi…
View article: Signalling Mechanism in TRPM2-dependent Copper- induced HT22 Cell Death
Signalling Mechanism in TRPM2-dependent Copper- induced HT22 Cell Death Open
Copper (Cu) is one of the critical elements needed by the human body. However, this metal can cause cytotoxicity when present in excess amounts. In this study, we used HT22 hippocampus cells to examine the function of the Ca2+-permeable tr…
View article: Effect of Secretion Efficiency of Mutant KRAS Neoantigen by Lactococcus lactis on the Immune Response of a Mucosal Vaccine Delivery Vehicle Targeting Colorectal Cancer
Effect of Secretion Efficiency of Mutant KRAS Neoantigen by Lactococcus lactis on the Immune Response of a Mucosal Vaccine Delivery Vehicle Targeting Colorectal Cancer Open
Colorectal cancer (CRC) is often caused by mutations in the KRAS oncogene, making KRAS neoantigens a promising vaccine candidate for immunotherapy. Secreting KRAS antigens using live Generally Recognized as Safe (GRAS) vaccine delivery hos…
View article: Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical TGF-β/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review
Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical TGF-β/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review Open
MicroRNAs (miRNAs) are a family of small, single-stranded, and non-protein coding RNAs about 19 to 22 nucleotides in length, that have been reported to have important roles in the control of bone development. MiRNAs have a strong influence…
View article: Expression of Influenza M2e-NP Recombinant Fusion Protein in Escherichia coli BL21 (DE3) and Its Binding to Antibodies
Expression of Influenza M2e-NP Recombinant Fusion Protein in Escherichia coli BL21 (DE3) and Its Binding to Antibodies Open
The current influenza vaccines only confer protection against the circulating influenza subtypes, therefore universal vaccines are needed to prevent upcoming influenza outbreaks caused by emerging influenza subtypes. The extracellular doma…
View article: Interleukin-27 Disrupts the Crosstalk of Apoptotic Activities between 4T1 Breast Cancer Cells and M2 Macrophages
Interleukin-27 Disrupts the Crosstalk of Apoptotic Activities between 4T1 Breast Cancer Cells and M2 Macrophages Open
Introduction: Cytokine immunotherapy such as Interleukin-27 (IL-27) has been foreseen as a promising alternative anti-cancer treatment. Thus, this study aimed to investigate whether IL-27 gene therapy regulates crosstalk between breast can…
View article: Fermented Black Tea and Its Relationship with Gut Microbiota and Obesity: A Mini Review
Fermented Black Tea and Its Relationship with Gut Microbiota and Obesity: A Mini Review Open
Fermentation is one of the world’s oldest techniques for food preservation, nutrient enhancement, and alcohol manufacturing. During fermentation, carbohydrates such as glucose and starch are converted into other molecules, such as alcohol …
View article: Morphological and Anatomical Studies on Glycosmis perakensis V.Naray (Rutaceae)
Morphological and Anatomical Studies on Glycosmis perakensis V.Naray (Rutaceae) Open
There are a number of underexplored plant species from the family of Rutaceae despite their economic importance, including Glycosmis perakensis V.Naray. Therefore, the main purpose of this study is to enhance its taxonomic characterization…
View article: Optimization of Signal Peptide via Site-Directed Mutagenesis for Enhanced Secretion of Heterologous Proteins in Lactococcus lactis
Optimization of Signal Peptide via Site-Directed Mutagenesis for Enhanced Secretion of Heterologous Proteins in Lactococcus lactis Open
Secretion efficiency of heterologous proteins in the Generally Regarded As Safe (GRAS) Lactococcus lactis is often reported to be insufficiently low due to limitations such as poor targeting and translocation by the signal peptide or degra…
View article: Clinical and Preclinical Studies of Fermented Foods and Their Effects on Alzheimer’s Disease
Clinical and Preclinical Studies of Fermented Foods and Their Effects on Alzheimer’s Disease Open
The focus on managing Alzheimer’s disease (AD) is shifting towards prevention through lifestyle modification instead of treatments since the currently available treatment options are only capable of providing symptomatic relief marginally …
View article: Morphology and Anatomy of Leaf, Stem and Petiole of Luvunga crassifolia Tanaka (Rutaceae)
Morphology and Anatomy of Leaf, Stem and Petiole of Luvunga crassifolia Tanaka (Rutaceae) Open
Luvunga crassifolia is an underutilized plant in the Citrus family. Other than brief morphological descriptions, there are no published reports on other identification features of this plant. Thus, the current study was aimed to investigat…
View article: Synergistic Cytotoxicity between Elephantopus scaber and Tamoxifen on MCF-7-Derived Multicellular Tumor Spheroid
Synergistic Cytotoxicity between Elephantopus scaber and Tamoxifen on MCF-7-Derived Multicellular Tumor Spheroid Open
Elephantopus scaber Linn, a traditional herb, exhibited anticancer properties, and it was cytotoxic against the monolayer estrogen receptor-positive breast cancer cell line, MCF-7, in the previous study. In order to determine the potential…
View article: Physicochemical characterization, cytotoxic effect and toxicity evaluation of nanostructured lipid carrier loaded with eucalyptol
Physicochemical characterization, cytotoxic effect and toxicity evaluation of nanostructured lipid carrier loaded with eucalyptol Open
View article: M2e-Based Influenza Vaccines with Nucleoprotein: A Review
M2e-Based Influenza Vaccines with Nucleoprotein: A Review Open
Discovery of conserved antigens for universal influenza vaccines warrants solutions to a number of concerns pertinent to the currently licensed influenza vaccines, such as annual reformulation and mismatching with the circulating subtypes.…
View article: Metagenomic and phytochemical analyses of kefir water and its subchronic toxicity study in BALB/c mice
Metagenomic and phytochemical analyses of kefir water and its subchronic toxicity study in BALB/c mice Open
View article: Selected Kefir Water from Malaysia Attenuates Hydrogen Peroxide-Induced Oxidative Stress by Upregulating Endogenous Antioxidant Levels in SH-SY5Y Neuroblastoma Cells
Selected Kefir Water from Malaysia Attenuates Hydrogen Peroxide-Induced Oxidative Stress by Upregulating Endogenous Antioxidant Levels in SH-SY5Y Neuroblastoma Cells Open
Kefir, a fermented probiotic drink was tested for its potential anti-oxidative, anti-apoptotic, and neuroprotective effects to attenuate cellular oxidative stress on human SH-SY5Y neuroblastoma cells. Here, the antioxidant potentials of th…
View article: Anti-Metastatic and Anti-Angiogenic Effects of Curcumin Analog DK1 on Human Osteosarcoma Cells In Vitro
Anti-Metastatic and Anti-Angiogenic Effects of Curcumin Analog DK1 on Human Osteosarcoma Cells In Vitro Open
Osteosarcoma (OS) is a life-threatening malignant bone tumor associated with poor prognosis among children. The survival rate of the patient is still arguably low even with intensive treatment provided, plus with the inherent side effects …
View article: Kefir and Its Biological Activities
Kefir and Its Biological Activities Open
Kefir is a fermented beverage with renowned probiotics that coexist in symbiotic association with other microorganisms in kefir grains. This beverage consumption is associated with a wide array of nutraceutical benefits, including anti-inf…
View article: Recombinant human Erythropoietin enhanced the cytotoxic effects of tamoxifen toward the spheroid MCF-7 breast cancer cells
Recombinant human Erythropoietin enhanced the cytotoxic effects of tamoxifen toward the spheroid MCF-7 breast cancer cells Open
Erythropoietin (EPO) is widely used to treat anemia in patients undergoing chemotherapy for cancers. The main objective of this study was to investigate the effect of rHuEPO on the response of spheroid breast cancer, MCF-7, cells to tamoxi…
View article: Regulation of Cellular and Cancer Stem Cell-Related Putative Gene Expression of Parental and CD44+CD24− Sorted MDA-MB-231 Cells by Cisplatin
Regulation of Cellular and Cancer Stem Cell-Related Putative Gene Expression of Parental and CD44+CD24− Sorted MDA-MB-231 Cells by Cisplatin Open
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that promotes a higher risk of metastasis and cancer reoccurrence. Cisplatin is one of the potential anticancer drugs for treating TNBC. However, the occurrence of…
View article: Cytotoxicity and Apoptosis Effects of Curcumin Analogue (2E,6E)-2,6-Bis(2,3-Dimethoxybenzylidine) Cyclohexanone (DMCH) on Human Colon Cancer Cells HT29 and SW620 In Vitro
Cytotoxicity and Apoptosis Effects of Curcumin Analogue (2E,6E)-2,6-Bis(2,3-Dimethoxybenzylidine) Cyclohexanone (DMCH) on Human Colon Cancer Cells HT29 and SW620 In Vitro Open
Colorectal cancer (CRC) is the third most common type of cancer worldwide and a leading cause of cancer death. According to the Malaysian National Cancer Registry Report 2012–2016, colorectal cancer was the second most common cancer in Mal…
View article: Induction of Apoptosis and Regulation of MicroRNA Expression by (2E,6E)-2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) Treatment on MCF-7 Breast Cancer Cells
Induction of Apoptosis and Regulation of MicroRNA Expression by (2E,6E)-2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) Treatment on MCF-7 Breast Cancer Cells Open
(2E,6E)-2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) is a synthetic curcumin analogue, which has been reported to possess anti-tumor, anti-metastatic, and anti-invasion properties on estrogen receptor (ER) negative breast …
View article: Recombinant Human erythropoietin reduces viability of MCF-7 breast cancer cells from 3D culture without caspase activation
Recombinant Human erythropoietin reduces viability of MCF-7 breast cancer cells from 3D culture without caspase activation Open
View article: Ethanol Induces Microglial Cell Death via the NOX/ROS/PARP/TRPM2 Signalling Pathway
Ethanol Induces Microglial Cell Death via the NOX/ROS/PARP/TRPM2 Signalling Pathway Open
Microglial cells are the primary immune cell resident in the brain. Growing evidence indicates that microglial cells play a prominent role in alcohol-induced brain pathologies. However, alcohol-induced effects on microglial cells and the u…
View article: Mixed Alkyltrimethylammonium-Alkylcarboxylate Surfactants Systems: A Potential Anti-Proliferation Agent for MDA-MB-231 Cancer Cell Line
Mixed Alkyltrimethylammonium-Alkylcarboxylate Surfactants Systems: A Potential Anti-Proliferation Agent for MDA-MB-231 Cancer Cell Line Open
Series of catanionic based alkyltrimethylammonium-alkylcarboxylate surfactants systems having different degree of alkyl chain length asymmetry were prepared and tested for their cytotoxicity against both fibroblast 3T3 and breast cancer MD…