Perry Barrett
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A missense mutation in zinc finger homeobox‐3 ( <span>ZFHX3</span> ) impedes growth and alters metabolism and hypothalamic gene expression in mice Open
A protein altering variant in the gene encoding zinc finger homeobox‐3 ( ZFHX3 ) has recently been associated with lower BMI in a human genome‐wide association study. We investigated metabolic parameters in mice harboring a missense mutati…
A missense mutation in zinc finger homeobox-3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in mice Open
A protein altering variant in the gene encoding zinc finger homeobox-3 ( ZFHX3 ) has recently been associated with lower BMI in a human genome-wide association study. We investigated metabolic parameters in mice harbouring a missense mutat…
Ovarian hormones induce de novo DNA methyltransferase expression in the Siberian hamster suprachiasmatic nucleus Open
The present study investigated neuroanatomically localised changes in de novo DNA methyltransferase expression in the female Siberian hamster ( Phodopus sungorus ). The objectives were to identify the neuroendocrine substrates that exhibit…
View article: Genome sequencing and transcriptome analyses of the Siberian hamster hypothalamus identify mechanisms for seasonal energy balance
Genome sequencing and transcriptome analyses of the Siberian hamster hypothalamus identify mechanisms for seasonal energy balance Open
Synthesis of triiodothyronine (T 3 ) in the hypothalamus induces marked seasonal neuromorphology changes across taxa. How species-specific responses to T 3 signaling in the CNS drive annual changes in body weight and energy balance remains…
Genetic, epigenetic and pharmacological influences modulating tissue specific regulation of the cannabinoid receptor-1 gene (CB <sub>1</sub> ); implications for cannabinoid pharmacogenetics Open
Cannabinoid receptor-1 (CB 1 ) represents a potential drug target against conditions that include obesity and substance abuse. However, drug trials targeting CB 1 (encoded by the CNR1 gene) have been compromised by differences in patient r…
A unifying hypothesis for control of body weight and reproduction in seasonally breeding mammals Open
Animals have evolved diverse seasonal variations in physiology and reproduction to accommodate yearly changes in environmental and climatic conditions. These changes in physiology are initiated by changes in photoperiod (daylength) and are…
View article: Correction: Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain
Correction: Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain Open
[This corrects the article DOI: 10.1371/journal.pone.0172724.].
View article: Alternation between short‐ and long photoperiod reveals hypothalamic gene regulation linked to seasonal body weight changes in Djungarian hamsters (<i>Phodopus sungorus</i>)
Alternation between short‐ and long photoperiod reveals hypothalamic gene regulation linked to seasonal body weight changes in Djungarian hamsters (<i>Phodopus sungorus</i>) Open
Djungarian hamsters are able to reduce their body weight by more than 30% in anticipation of the winter season. This particular adaptation to extreme environmental conditions is primarily driven by a natural reduction in day length and con…
Safety, Pharmacokinetics, and Antiviral Activity of a Novel HIV Antiviral, ABX464, in Treatment-Naive HIV-Infected Subjects in a Phase 2 Randomized, Controlled Study Open
We investigated the safety and antiviral effects of an anti-HIV compound (ABX464) with a unique mechanism of viral replication inhibition. This was a randomized, double-blind, placebo-controlled, dose-ranging study in treatment-naive HIV-i…
View article: Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain
Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain Open
[This corrects the article DOI: 10.1371/journal.pone.0172724.].
Steady-state energy balance in animal models of obesity and weight loss Open
Objective: We wanted to exam the steady-state energy balance by using high-fat diet-induced obese (DIO) rats and mice as models for positive energy balance, and gastric bypassed (GB) rats and gene knockout of muscarinic acetylcholine M3 re…
Randomized Trial of Food Effect on Pharmacokinetic Parameters of ABX464 Administered Orally to Healthy Male Subjects Open
ABX464 is an antiviral that provides a novel approach to the reduction and control of HIV infection. Investigation of food influence is important in the optimization of treatment. An open-label, food effect, randomized study which included…
Preclinical models for obesity research Open
A multi-dimensional strategy to tackle the global obesity epidemic requires an in-depth understanding of the mechanisms that underlie this complex condition. Much of the current mechanistic knowledge has arisen from preclinical research pe…
View article: Seasonal Control of Mammalian Energy Balance: Recent Advances in the Understanding of Daily Torpor and Hibernation
Seasonal Control of Mammalian Energy Balance: Recent Advances in the Understanding of Daily Torpor and Hibernation Open
Endothermic mammals and birds require intensive energy turnover to sustain high body temperatures and metabolic rates. To cope with the energetic bottlenecks associated with the change of seasons, and to minimise energy expenditure, comple…
Pharmacokinetics and tolerability of ABX464, a novel first-in-class compound to treat HIV infection, in healthy HIV-uninfected subjects Open
These studies confirmed that ABX464 is well tolerated and rapidly and substantially metabolized into ABX464-NGlc in human subjects.