Liliana N. Berti‐Mattera
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Effects of p38 MAPK Inhibition on Early Stages of Diabetic Retinopathy and Sensory Nerve Function Open
Purpose. p38 mitogen-activated protein kinase (MAPK) is known to play a regulatory role in inflammatory processes in disease. Inflammation has been linked also to the development of diabetic retinopathy in rodents. This study was conducted…
Delayed restoration of Mg<sup>2+</sup>content and transport in liver cells following ethanol withdrawal Open
Liver cells from rats chronically fed a Lieber-De Carli diet for 3 wk presented a marked decreased in tissue Mg 2+ content and an inability to extrude Mg 2+ into the extracellular compartment upon stimulation with catecholamine, isoprotere…
Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats Open
OBJECTIVE—Diabetic neuropathy is manifested either by loss of nociception (painless syndrome) or by mechanical hyperalgesia and tactile allodynia (pain in response to nonpainful stimuli). While therapies with vasodilators or neurotrophins …
Activin Induces Tactile Allodynia and Increases Calcitonin Gene-Related Peptide after Peripheral Inflammation Open
Calcitonin gene-related peptide (CGRP) is a sensory neuropeptide important in inflammatory pain that conveys pain information centrally and dilates blood vessels peripherally. Previous studies indicate that activin A increases CGRP-immunor…
Proliferative and morphological effects of endothelins in Schwann cells: roles of p38 mitogen‐activated protein kinase and Ca<sup>2+</sup>‐independent phospholipase A<sub>2</sub> Open
The regulation of Schwann cell (SC) proliferation and morphology is critical to nerve homeostasis. We have previously reported that endothelins (ETs) regulate the activity of different effectors in SC including adenylyl cyclase, phospholip…
The Human V<sub>3</sub>Pituitary Vasopressin Receptor: Ligand Binding Profile and Density-Dependent Signaling Pathways<sup>1</sup> Open
The vasopressin (AVP) V3 pituitary receptor (V3R) is a G protein-coupled corticotropic phenotypic marker that is overexpressed in ACTH-hypersecreting tumors. Studies of the agonist/antagonist binding profile and signal transduction pathway…
P2-purigenic receptors regulate phospholipase C and adenylate cyclase activities in immortalized Schwann cells Open
Schwann cells play an important role in both the development and regeneration of peripheral nerves. Proliferation and differentiation of Schwann cells are critically dependent on changes in the levels of cAMP. ATP is a fast excitatory tran…
Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor. Open
Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonapeptide that acts through binding to G protein-coupled specific membrane receptors pharmacologically divided into three subtypes (V1a, V1b, and V2) linked to distinct second mess…
Proximal tubular epithelial cells possess a novel 42-kilodalton guanine nucleotide-binding regulatory protein. Open
The proximal tubule of the kidney represents an important location where adenylate cyclase regulates salt and water transport; yet a detailed characterization of the distribution and classification of guanine nucleotide-binding protein (G …