Bhaskar Dasgupta
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View article: Population Pharmacokinetics and Exposure‐Response Analyses of Sarilumab in Patients with Polymyalgia Rheumatica
Population Pharmacokinetics and Exposure‐Response Analyses of Sarilumab in Patients with Polymyalgia Rheumatica Open
Sarilumab (interleukin‐6 receptor inhibitor) is approved in the United States and Europe for polymyalgia rheumatica (PMR). This study characterized sarilumab pharmacokinetics (PK) and assessed the influence of intrinsic and extrinsic facto…
View article: Reliability of the OMERACT Giant cell arteritis Ultrasonography Score (OGUS): results of a patient-based exercise involving experts and non-experts in vascular ultrasonography
Reliability of the OMERACT Giant cell arteritis Ultrasonography Score (OGUS): results of a patient-based exercise involving experts and non-experts in vascular ultrasonography Open
Objective To test the reliability of the Outcome Measures in Rheumatology Giant cell arteritis (GCA) Ultrasonography Score (OGUS) and other composite scores in a patient-based exercise involving experts and non-experts in vascular ultrason…
View article: Enhancing rheumatology training: The POCRUS model for integrating ultrasound into clinical practice. (From APLAR imaging SIG)
Enhancing rheumatology training: The POCRUS model for integrating ultrasound into clinical practice. (From APLAR imaging SIG) Open
The use of ultrasound (US) has increasingly become an established part of routine clinical practice in rheumatology. However, there is still a debate over whether all rheumatologists should learn US examination skills. Nonetheless, all rhe…
View article: Diagnostic accuracy of OGUS, Southend halo score and halo count in giant cell arteritis
Diagnostic accuracy of OGUS, Southend halo score and halo count in giant cell arteritis Open
Objectives Ultrasound has a paramount role in the diagnostic assessment of giant cell arteritis (GCA); Southend halo score (HS), halo count (HC), and OMERACT GCA Ultrasonography Score (OGUS) are the first quantitative scores proposed in th…
View article: Estimating overdiagnosis in giant cell arteritis diagnostic pathways using genetic data: genetic association study
Estimating overdiagnosis in giant cell arteritis diagnostic pathways using genetic data: genetic association study Open
Objectives GCA can be confirmed by temporal artery biopsy (TAB) but false negatives can occur. GCA may be overdiagnosed in TAB-negative cases, or if neither TAB nor imaging is done. We used HLA genetic association of TAB-positive GCA as an…
View article: An innovative hybrid training method for ultrasound in giant cell arteritis, polymyalgia rheumatica and large vessel vasculitis
An innovative hybrid training method for ultrasound in giant cell arteritis, polymyalgia rheumatica and large vessel vasculitis Open
To circumvent the lack of hands-on ultrasound training resulting from inability to conduct face-to-face workshops during the COVID-19 pandemic, especially as local expertise was not available, we developed a novel hybrid method combining v…
View article: Treat-to-target recommendations in giant cell arteritis and polymyalgia rheumatica
Treat-to-target recommendations in giant cell arteritis and polymyalgia rheumatica Open
These are the first T2T recommendations for GCA and PMR. Treatment targets, as well as strategies to assess, achieve and maintain these targets have been defined. The research agenda highlights the gaps in evidence and the need for future …
View article: An international survey of current management practices for polymyalgia rheumatica by general practitioners and rheumatologists
An international survey of current management practices for polymyalgia rheumatica by general practitioners and rheumatologists Open
Objectives To explore current management practices for PMR by general practitioners (GPs) and rheumatologists including implications for clinical trial recruitment. Methods An English language questionnaire was constructed by a working gro…
View article: Dimensional synthesis of spatial manipulators for velocity and force transmission for operation around a specified task point
Dimensional synthesis of spatial manipulators for velocity and force transmission for operation around a specified task point Open
Dimensional synthesis refers to design of the dimensions of manipulators by optimising different kinds of performance indices. The motivation of this study is to perform dimensional synthesis for a wide set of spatial manipulators by optim…
View article: Enumeration of spatial manipulators by using the concept of Adjacency Matrix
Enumeration of spatial manipulators by using the concept of Adjacency Matrix Open
This study is on the enumeration of spatial robotic manipulators, which is an essential basis for a companion study on dimensional synthesis, both of which together present a wider utility in manipulator synthesis. The enumeration of manip…