Christopher N. Bowman
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View article: Digital light processing of photoresponsive and programmable hydrogels
Digital light processing of photoresponsive and programmable hydrogels Open
Light-mediated manipulation of hydrogel physicochemical properties is attractive for numerous applications, yet the processing of such hydrogels via vat photopolymerization [e.g., digital light processing (DLP)] is challenging as photoresp…
View article: Mechanophore Integration in Crosslinked Step‐ and Chain‐Polymerized Polymers and the Resulting Material Properties
Mechanophore Integration in Crosslinked Step‐ and Chain‐Polymerized Polymers and the Resulting Material Properties Open
A facile synthesis, preparation, and integration of a diacrylate‐functionalized mechanophore is presented to demonstrate that a single, identical mechanophore is readily incorporated into polymer networks of various origins as a tool for i…
View article: Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response
Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response Open
Plant homeodomain (PHD) fingers are critical effectors of histone post-translational modifications (PTMs), regulating gene expression and genome integrity, and are frequently implicated in human disease. While most PHD fingers recognize un…
View article: 1,2-Dithiolane/yne photopolymerizations to generate high refractive index polymers
1,2-Dithiolane/yne photopolymerizations to generate high refractive index polymers Open
Photoinitiated copolymerization of dithiolanes and alkynes results in copolymers with high refractive indices. Transmission holography performed via this reaction results in stable, high diffraction efficiency gratings with low haze, biref…
View article: Multifunctional dithiolane monomers for multi-scale, recyclable light-driven additive manufacturing
Multifunctional dithiolane monomers for multi-scale, recyclable light-driven additive manufacturing Open
Multifunctional dithiolane monomers were prepared, polymerized, printed across multiple length scales, and recycled.
View article: Photodegradable polyacrylamide tanglemers enable spatiotemporal control over chain lengthening in high-strength and low-hysteresis hydrogels
Photodegradable polyacrylamide tanglemers enable spatiotemporal control over chain lengthening in high-strength and low-hysteresis hydrogels Open
Polyacrylamide tanglemers with photodegradable crosslinkers afford spatiotemporal control over the stability of entanglement-trapping crosslinks, influencing regional swelling and increased extensibility via chain lengthening.
View article: Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response
Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response Open
Plant homeodomain (PHD) fingers are critical effectors of histone post-translational modifications (PTMs), acting as regulators of gene expression and genome integrity, and frequently presenting in human disease. While most PHD fingers rec…
View article: Abstracts of the 2024 50th Annual NATAS Conference
Abstracts of the 2024 50th Annual NATAS Conference Open
The 50th annual conference of the North American Thermal Analysis Society is being held jointly with the 8th Baekeland Symposium to bring those communities together. NATAS offers scientists and practitioners the opportunity to explore the …
View article: Photochemical Control of Network Topology in PEG Hydrogels
Photochemical Control of Network Topology in PEG Hydrogels Open
Hydrogels are often synthesized through photoinitiated step‐, chain‐, and mixed‐mode polymerizations, generating diverse network topologies and resultant material properties that depend on the underlying network connectivity. While many ph…
View article: Radical‐Mediated Degradation of Thiol–Maleimide Hydrogels
Radical‐Mediated Degradation of Thiol–Maleimide Hydrogels Open
Michael addition between thiol‐ and maleimide‐functionalized molecules is a long‐standing approach used for bioconjugation, hydrogel crosslinking, and the functionalization of other advanced materials. While the simplicity of this chemistr…
View article: Sonication labile PEG-based hydrogel system for biological component suspension and subsequent degradation
Sonication labile PEG-based hydrogel system for biological component suspension and subsequent degradation Open
Phthalaldehyde incorporation in hydrogels to yield mechanically degradable materials shown to be compatible with biological component suspension and release.
View article: Reversible Intracellular Gelation of MCF10A Cells Enables Programmable Control Over 3D Spheroid Growth
Reversible Intracellular Gelation of MCF10A Cells Enables Programmable Control Over 3D Spheroid Growth Open
In nature, some organisms survive extreme environments by inducing a biostatic state wherein cellular contents are effectively vitrified. Recently, a synthetic biostatic state in mammalian cells is achieved via intracellular network format…
View article: Facile Physicochemical Reprogramming of PEG‐Dithiolane Microgels
Facile Physicochemical Reprogramming of PEG‐Dithiolane Microgels Open
Granular biomaterials have found widespread applications in tissue engineering, in part because of their inherent porosity, tunable properties, injectability, and 3D printability. However, the assembly of granular hydrogels typically relie…
View article: Photoinduced Dithiolane Crosslinking for Multiresponsive Dynamic Hydrogels
Photoinduced Dithiolane Crosslinking for Multiresponsive Dynamic Hydrogels Open
While many hydrogels are elastic networks crosslinked by covalent bonds, viscoelastic hydrogels with adaptable crosslinks are increasingly being developed to better recapitulate time and position‐dependent processes found in many tissues. …
View article: Leaping liquid crystal elastomers
Leaping liquid crystal elastomers Open
Snap-through mechanisms are pervasive in everyday life in biological systems, engineered devices, and consumer products. Snap-through transitions can be realized in responsive materials via stimuli-induced mechanical instability. Here, we …
View article: Discontinuous metric programming in liquid crystalline elastomers
Discontinuous metric programming in liquid crystalline elastomers Open
Liquid crystalline elastomers (LCEs) are shape-changing materials that exhibit large deformations in response to applied stimuli. Local control of the orientation of LCEs spatially directs the deformation of these materials to realize spon…
View article: Surface‐Enforced Alignment of Reprogrammable Liquid Crystalline Elastomers
Surface‐Enforced Alignment of Reprogrammable Liquid Crystalline Elastomers Open
Liquid crystalline elastomers (LCEs) are stimuli‐responsive materials capable of undergoing large deformations. The thermomechanical response of LCEs is attributable to the coupling of polymer network properties and disruption of order bet…
View article: Intracellular Crowding by Bio‐Orthogonal Hydrogel Formation Induces Reversible Molecular Stasis
Intracellular Crowding by Bio‐Orthogonal Hydrogel Formation Induces Reversible Molecular Stasis Open
To survive extreme conditions, certain animals enter a reversible protective stasis through vitrification of the cytosol by polymeric molecules such as proteins and polysaccharides. In this work, synthetic gelation of the cytosol in living…
View article: Tunable Surfaces and Films from Thioester Containing Microparticles
Tunable Surfaces and Films from Thioester Containing Microparticles Open
This document is the unedited Author's version of a Submitted Work that was subsequently accepted for publication in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review. To access the final edited an…
View article: Synthesis, selective decoration and photocrosslinking of <scp>self‐immolative</scp> poly(thioester)‐PEG hydrogels
Synthesis, selective decoration and photocrosslinking of <span>self‐immolative</span> poly(thioester)‐PEG hydrogels Open
Self‐immolative polymers are a class of polymers that undergo linear depolymerization of the main chain, often triggered by a single initial degradation event. Chain‐unzipping immolation processes followed by low‐ceiling‐temperature polyme…
View article: Athermal, Chemically Triggered Release of RNA from Thioester Nucleic Acids
Athermal, Chemically Triggered Release of RNA from Thioester Nucleic Acids Open
An athermal approach to mRNA enrichment from total RNA using a self‐immolative thioester linked nucleic acids (TENA) is described. Oligo(thymine) (oT) TENA has a six‐atom spacing between bases which allowed TENA to selectively base‐pair wi…
View article: 3D printing of sacrificial thioester elastomers using digital light processing for templating 3D organoid structures in soft biomatrices
3D printing of sacrificial thioester elastomers using digital light processing for templating 3D organoid structures in soft biomatrices Open
Biofabrication allows for the templating of structural features in materials on cellularly-relevant size scales, enabling the generation of tissue-like structures with controlled form and function. This is particularly relevant for growing…
View article: Photoclick Chemistry: A Bright Idea
Photoclick Chemistry: A Bright Idea Open
At its basic conceptualization, photoclick chemistry embodies a collection of click reactions that are performed via the application of light. The emergence of this concept has had diverse impact over a broad range of chemical and biologic…
View article: Synthesis and Characterization of Click Nucleic Acid Conjugated Polymeric Microparticles for DNA Delivery Applications
Synthesis and Characterization of Click Nucleic Acid Conjugated Polymeric Microparticles for DNA Delivery Applications Open
Microparticle-mediated nucleic acid delivery is a popular strategy to achieve therapeutic outcomes via antisense gene therapy. However, current methods used to fabricate polymeric microparticles suffer from suboptimal properties such as pa…
View article: Charged Poly(<i>N</i>-isopropylacrylamide) Nanogels for the Stabilization of High Isoelectric Point Proteins
Charged Poly(<i>N</i>-isopropylacrylamide) Nanogels for the Stabilization of High Isoelectric Point Proteins Open
Storage and transportation of protein therapeutics using refrigeration is a costly process; a reliable electrical supply is vital, expensive equipment is needed, and unique transportation is required. Reducing the reliance on the cold chai…
View article: Effects of Network Structures on the Tensile Toughness of Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC)-Based Photopolymers
Effects of Network Structures on the Tensile Toughness of Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC)-Based Photopolymers Open
In the present study, the photo-initiated copper-catalyzed azide-alkyne cycloaddition (CuAAC) polymerization was utilized to form structurally diverse glassy polymer networks. Systematic alterations in the monomer backbone rigidity (e.g., …
View article: Determining Michael acceptor reactivity from kinetic, mechanistic, and computational analysis for the base-catalyzed thiol-Michael reaction
Determining Michael acceptor reactivity from kinetic, mechanistic, and computational analysis for the base-catalyzed thiol-Michael reaction Open
A systematic investigation extends the fundamental understanding of the structure–property relationships between vinyl functionality and the reaction kinetics for the thiol-Michael reactions.
View article: The contribution of intermolecular forces to phototropic actuation of liquid crystalline elastomers
The contribution of intermolecular forces to phototropic actuation of liquid crystalline elastomers Open
Azobenzene-functionalized crystalline elastomers containing a monomer with reduced aromatic content exhibits enhanced phototropic response.
View article: Surface Modification of (Non)‐Fluorinated Vitrimers through Dynamic Transamination
Surface Modification of (Non)‐Fluorinated Vitrimers through Dynamic Transamination Open
Surface modifications are typically permanent in shape and chemistry. Herein, vinylogous urethane (VU) chemistry is presented as an easily accessible and versatile platform for rapid, facile, and reworkable surface modification. It is demo…