Nigel Curtis
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View article: Dental Caries Detection in Children Using Intraoral Scanners Featuring Fluorescence: Diagnostic Agreement Study
Dental Caries Detection in Children Using Intraoral Scanners Featuring Fluorescence: Diagnostic Agreement Study Open
Background Dental caries is a common chronic disease in children. Digital tools such as intraoral scanners (IOSs) may offer an efficient, scalable alternative to conventional visual examination for dental caries detection. IOSs are handhel…
View article: Neonatal Bacillus Calmette‐Guérin Vaccination Decreases Eczema Incidence at 5 years: The <scp>MIS BAIR</scp> Randomised Controlled Trial
Neonatal Bacillus Calmette‐Guérin Vaccination Decreases Eczema Incidence at 5 years: The <span>MIS BAIR</span> Randomised Controlled Trial Open
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View article: Dental caries detection in children using intraoral scans and deep learning
Dental caries detection in children using intraoral scans and deep learning Open
This study represents an exploratory effort towards developing AI-assisted caries detection using intraoral scanner data in children. While the long-term potential of such technology could include support for early diagnosis, enhanced cari…
View article: Neonatal <scp>BCG</scp> vaccination to prevent asthma: Results from the <scp>MIS BAIR</scp> randomized controlled trial
Neonatal <span>BCG</span> vaccination to prevent asthma: Results from the <span>MIS BAIR</span> randomized controlled trial Open
Background Asthma has a significant impact worldwide, but prevention strategies remain limited. We aimed to evaluate the efficacy of neonatal BCG vaccination in preventing asthma by modulating early‐life immunity. Methods The Melbourne Inf…
View article: Immune impacts of infant whole-cell and acellular pertussis vaccination on co-administered vaccines
Immune impacts of infant whole-cell and acellular pertussis vaccination on co-administered vaccines Open
A mixed wP/aP schedule resulted in non-inferior IgG responses to co-administered vaccine antigens compared to the standard aP-only schedule for pertussis primary immunisation.
View article: Optimising COVID-19 Episode Identification Using Serology and PCR/Rapid Antigen Testing: Insights from the BRACE Trial
Optimising COVID-19 Episode Identification Using Serology and PCR/Rapid Antigen Testing: Insights from the BRACE Trial Open
Background Accurately identifying COVID-19 episodes was crucial during the pandemic for evaluating interventions. Results from diagnostic tools like PCR, rapid antigen test (RAT) and serology are affected by factors such as timing of tests…
View article: Relationship between posaconazole concentrations and clinical outcomes in paediatric cancer and haematopoietic stem cell transplant recipients
Relationship between posaconazole concentrations and clinical outcomes in paediatric cancer and haematopoietic stem cell transplant recipients Open
Background Posaconazole is used to prevent and treat invasive fungal infections (IFIs) in immunocompromised children, including those undergoing cancer treatment or HSCT. Despite differences in pharmacokinetics and IFI epidemiology between…
View article: Immunogenicity of co-administered vaccine antigens with whole-cell or acellular pertussis vaccines in infancy: a randomised controlled trial
Immunogenicity of co-administered vaccine antigens with whole-cell or acellular pertussis vaccines in infancy: a randomised controlled trial Open
Summary Background Whole-cell pertussis (wP) and acellular pertussis (aP) vaccines evoke different immune responses to pertussis vaccine antigens. We compared the effect of a heterologous wP/aP/aP primary series (hereafter mixed wP/aP) ver…
View article: Characterising the SARS-CoV-2 nucleocapsid (N) protein antibody response
Characterising the SARS-CoV-2 nucleocapsid (N) protein antibody response Open
OBJECTIVES: SARS-CoV-2 nucleocapsid (N) protein antibodies can be used to detect the serological response to natural infection in those previously receiving a COVID-19 spike-based vaccine. Anti-N antibody responses can also be detected in …
View article: Effect of Bacille Calmette–Guérin vaccination on immune responses to SARS‐CoV‐2 and COVID‐19 vaccination
Effect of Bacille Calmette–Guérin vaccination on immune responses to SARS‐CoV‐2 and COVID‐19 vaccination Open
Objectives Bacille Calmette–Guérin (BCG) vaccination has off‐target effects on disease risk for unrelated infections and immune responses to vaccines. This study aimed to determine the immunomodulatory effects of BCG vaccination on immune …
View article: Systematic review of the impact of intestinal microbiota on vaccine responses
Systematic review of the impact of intestinal microbiota on vaccine responses Open
The intestinal microbiota plays a critical role in host immunity and might contribute to the significant variation between individuals’ vaccine responses. A systematic search was done using MEDLINE and Embase to identify original human stu…
View article: The association between prenatal antibiotic exposure and adverse long-term health outcomes in children: A systematic review and meta-analysis
The association between prenatal antibiotic exposure and adverse long-term health outcomes in children: A systematic review and meta-analysis Open
Although causality cannot be implied, these findings support antibiotic stewardship efforts to ensure judicious use of antibiotics during pregnancy to avoid potential long-term health risks.
View article: The effect of antibiotics on the intestinal microbiota in children - a systematic review
The effect of antibiotics on the intestinal microbiota in children - a systematic review Open
Background Children are the age group with the highest exposure to antibiotics (ABX). ABX treatment changes the composition of the intestinal microbiota. The first few years of life are crucial for the establishment of a healthy microbiota…
View article: BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial
BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial Open
ClinicalTrials.gov NCT04327206.
View article: Neonatal BCG Vaccination for Prevention of Allergy in Infants: The MIS BAIR Randomised Controlled Trial
Neonatal BCG Vaccination for Prevention of Allergy in Infants: The MIS BAIR Randomised Controlled Trial Open
Background The beneficial off‐target effects of Bacille Calmette–Guérin (BCG) vaccination potentially include protection against allergy. Objective In the MIS BAIR trial, we aimed to determine whether neonatal BCG vaccination reduces atopi…
View article: Immunogenicity, reactogenicity, and IgE-mediated immune responses of a mixed whole-cell and acellular pertussis vaccine schedule in Australian infants: A randomised, double-blind, noninferiority trial
Immunogenicity, reactogenicity, and IgE-mediated immune responses of a mixed whole-cell and acellular pertussis vaccine schedule in Australian infants: A randomised, double-blind, noninferiority trial Open
Background In many countries, infant vaccination with acellular pertussis (aP) vaccines has replaced use of more reactogenic whole-cell pertussis (wP) vaccines. Based on immunological and epidemiological evidence, we hypothesised that subs…
View article: Accelerated Bacille Calmette-Guérin reactions: More than meets the eye
Accelerated Bacille Calmette-Guérin reactions: More than meets the eye Open
An accelerated local injection site reaction following Bacille Calmette-Guérin (BCG) vaccination has been associated with underlying active tuberculosis (TB) in high TB-prevalence settings. The clinical significance of this accelerated BCG…
View article: Posaconazole in paediatric malignancy and haematopoietic stem cell transplant: dosing to achieve therapeutic concentration
Posaconazole in paediatric malignancy and haematopoietic stem cell transplant: dosing to achieve therapeutic concentration Open
Objectives Posaconazole is increasingly used for the treatment and prophylaxis of invasive fungal infections in immunocompromised children. We aimed to review evidence for paediatric posaconazole dosing regimens focusing on attainment of t…
View article: Factors influencing adverse events following COVID-19 vaccination
Factors influencing adverse events following COVID-19 vaccination Open
Various novel platform technologies have been used for the development of COVID-19 vaccines. In this nested cohort study among healthcare workers in Australia and Brazil who received three different COVID-19-specific vaccines, we (a) evalu…
View article: Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial
Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial Open
For the Portuguese translation of the abstract see Supplementary Materials section.
View article: Humoral and cellular immune responses in vaccinated and unvaccinated children following SARS‐CoV‐2 Omicron infection
Humoral and cellular immune responses in vaccinated and unvaccinated children following SARS‐CoV‐2 Omicron infection Open
Objectives The immune response in children elicited by SARS‐CoV‐2 Omicron infection alone or in combination with COVID‐19 vaccination (hybrid immunity) is poorly understood. We examined the humoral and cellular immune response following SA…
View article: Immunogenicity, reactogenicity, and IgE-mediated immune responses of a mixed whole-cell and acellular pertussis vaccine schedule in Australian infants: a randomised, double-blind, non-inferiority trial
Immunogenicity, reactogenicity, and IgE-mediated immune responses of a mixed whole-cell and acellular pertussis vaccine schedule in Australian infants: a randomised, double-blind, non-inferiority trial Open
Summary Background In most high-income countries, infant vaccination with acellular pertussis (aP) vaccines is the standard of care for the prevention of pertussis disease. Based on immunological and epidemiological evidence, we hypothesis…
View article: 475. "The Outcomes and Adverse Effects of COVID-19 Therapies in High-Risk Children"
475. "The Outcomes and Adverse Effects of COVID-19 Therapies in High-Risk Children" Open
Background Numerous international studies have focused on the outcomes of COVID-19 therapies in adults, however data are limited on the outcomes for high-risk paediatric patients treated with similar agents. Methods Data was collected retr…
View article: 2904. Use Of Biofire® Joint Infection Filmarray for the Microbiological Diagnosis of Acute Hematogenous Septic Arthritis in Children
2904. Use Of Biofire® Joint Infection Filmarray for the Microbiological Diagnosis of Acute Hematogenous Septic Arthritis in Children Open
Background Making a microbiological diagnosis in paediatric joint infections is challenging due to the high proportion of fastidious pathogens, in particular Kingella kingae. The Biofire® Joint Infection (JI) Panel allows the rapid molecul…