Nancy E. Davidson
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View article: Drug screening in 3D microtumors reveals DDR1/2-MAPK12-GLI1 as a vulnerability in cancer-associated fibroblasts
Drug screening in 3D microtumors reveals DDR1/2-MAPK12-GLI1 as a vulnerability in cancer-associated fibroblasts Open
View article: RecOVARY? Using anti-Müllerian hormone to predict ovarian function after anti-HER2 therapy for early breast cancer
RecOVARY? Using anti-Müllerian hormone to predict ovarian function after anti-HER2 therapy for early breast cancer Open
View article: Gonadal Hormone Changes with Aging and Their Impact on Chronic Pain
Gonadal Hormone Changes with Aging and Their Impact on Chronic Pain Open
Chronic pain, pain that lasts beyond three months, is a common finding in the elderly. It is often due to musculoskeletal conditions but can be precipitated by other factors as well. While physiological systems decline with aging, chronic …
View article: Fluoroestradiol (FES) and Fluorodeoxyglucose (FDG) PET imaging in patients with ER+, HER2-positive or HER2-negative metastatic breast cancer
Fluoroestradiol (FES) and Fluorodeoxyglucose (FDG) PET imaging in patients with ER+, HER2-positive or HER2-negative metastatic breast cancer Open
Background 18F-Fluorodeoxyglucose (FDG) and 18F-Fluorestradiol (FES) have been FDA approved for measuring tumor glycolytic activity and estrogen receptor (ER) uptake, respectively, in clinical positron emission tomogr…
View article: Breast Cancer Index in Premenopausal Women With Early-Stage Hormone Receptor–Positive Breast Cancer
Breast Cancer Index in Premenopausal Women With Early-Stage Hormone Receptor–Positive Breast Cancer Open
Importance Adjuvant ovarian function suppression (OFS) with oral endocrine therapy improves outcomes for premenopausal patients with hormone receptor–positive (HR + ) breast cancer but adds adverse effects. A genomic biomarker for selectin…
View article: Computational pathology improves risk stratification of a multi-gene assay for early stage ER+ breast cancer
Computational pathology improves risk stratification of a multi-gene assay for early stage ER+ breast cancer Open
View article: Supplementary Figure 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplementary Figure S1. Experimental design and quality control analysis for Methyl-Seq data. (A) FVB mice were bred to become pregnant (parous, P) and underwent a complete pregnancy (Pr), lactation (L), and Involution (I). Animals were t…
View article: Table S3 from AACR Project GENIE: Powering Precision Medicine through an International Consortium
Table S3 from AACR Project GENIE: Powering Precision Medicine through an International Consortium Open
Table S3
View article: Supplementary Figure 4 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 4 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Figure S4. Full representation of CpG methylation analysis in the confirmation of Methyl-Seq DNA methylation by bisulfite sequencing. (A) The percent methylation for each CpG site after bisulfite sequencing on mammary gland ge…
View article: Supplementary Figure 2 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 2 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Figure S2. All samples from both time points were used in a hierarchal clustering analysis. 10 samples at the early time point and 11 samples at the late time point were included.(E=early, L=late, P=parous, NP=nulliparous)
View article: Supplementary Figure Legends from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure Legends from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
All Supplementary Figure legends are included in this document.
View article: Supplementary Figure 3 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 3 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Figure S3. Mapping efficiency was above 50 for all samples in both time points. One sample was an outlier in the early time point (P12) and one at the late time point (NP4) and were removed from further analysis. Both Pearson …
View article: Supplementary methods, tables and figures. from Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative
Supplementary methods, tables and figures. from Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative Open
File with the supplementary material & methods, supplementary tables and supplementary figure.
View article: Supplemental Methods, Supplemental Tables 1-2, Supplemental Figures 1-4 from AACR Project GENIE: Powering Precision Medicine through an International Consortium
Supplemental Methods, Supplemental Tables 1-2, Supplemental Figures 1-4 from AACR Project GENIE: Powering Precision Medicine through an International Consortium Open
Supplemental Methods. Supplemental Table 1: ââ,¬â€¹Genomic Data Characterization by Center. Supplemental Table 2: ââ,¬â€¹Gene Panels Submitted by Each Center. Figure S1: Number of putative germline SNPs per sample, before and after unifo…
View article: Supplementary file - liver genes from Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative
Supplementary file - liver genes from Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening Initiative Open
Supplementary file with the listing of the liver genes excluded from transcriptomic analyses.
View article: Table S4 from AACR Project GENIE: Powering Precision Medicine through an International Consortium
Table S4 from AACR Project GENIE: Powering Precision Medicine through an International Consortium Open
Table S4
View article: Data from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Data from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
The most effective natural prevention against breast cancer is an early first full-term pregnancy. Understanding how the protective effect is elicited will inform the development of new prevention strategies. To better understand the role …
View article: Data from AACR Project GENIE: Powering Precision Medicine through an International Consortium
Data from AACR Project GENIE: Powering Precision Medicine through an International Consortium Open
The AACR Project GENIE is an international data-sharing consortium focused on generating an evidence base for precision cancer medicine by integrating clinical-grade cancer genomic data with clinical outcome data for tens of thousands of c…
View article: Supplementary Figure 9 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 9 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S9. Differentially methylated regions of IGF pathway genes align with histone methylation sites. The UCSC Genome Browser was used to align the Irs1, Igf1, and Igfbp4 with other epigenetic modifications. The red bars indica…
View article: Supplementary Figure 8 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 8 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S8. Hypermethylation of the Igf1r aligns with sites of histone methylation. (A) The UCSC Genome Browser was used to align the Igf1r with other epigenetic modifications. The red bar indicates the region of differential DNA …
View article: Supplementary Table 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Table 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Primers used for quantitative PCR and bisulfite sequencing.
View article: Supplementary Figure 5 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 5 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S5. Imprinted genes display approximately 50% DNA methylation. Gene regions known to be imprinted were chosen to confirm the validity of the Methyl-Seq assay. For each gene a β value was calculated for each window. The fre…
View article: Supplementary Figure 9 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 9 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S9. Differentially methylated regions of IGF pathway genes align with histone methylation sites. The UCSC Genome Browser was used to align the Irs1, Igf1, and Igfbp4 with other epigenetic modifications. The red bars indica…
View article: Supplementary Figure 5 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 5 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S5. Imprinted genes display approximately 50% DNA methylation. Gene regions known to be imprinted were chosen to confirm the validity of the Methyl-Seq assay. For each gene a β value was calculated for each window. The fre…
View article: Supplemental File 1 from AACR Project GENIE: Powering Precision Medicine through an International Consortium
Supplemental File 1 from AACR Project GENIE: Powering Precision Medicine through an International Consortium Open
AACR GENIE Data Guide
View article: Table S3 from AACR Project GENIE: Powering Precision Medicine through an International Consortium
Table S3 from AACR Project GENIE: Powering Precision Medicine through an International Consortium Open
Table S3
View article: Supplemental Methods, Supplemental Tables 1-2, Supplemental Figures 1-4 from AACR Project GENIE: Powering Precision Medicine through an International Consortium
Supplemental Methods, Supplemental Tables 1-2, Supplemental Figures 1-4 from AACR Project GENIE: Powering Precision Medicine through an International Consortium Open
Supplemental Methods. Supplemental Table 1: ââ,¬â€¹Genomic Data Characterization by Center. Supplemental Table 2: ââ,¬â€¹Gene Panels Submitted by Each Center. Figure S1: Number of putative germline SNPs per sample, before and after unifo…
View article: Supplementary Figure 3 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 3 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Figure S3. Mapping efficiency was above 50 for all samples in both time points. One sample was an outlier in the early time point (P12) and one at the late time point (NP4) and were removed from further analysis. Both Pearson …
View article: Supplementary Figure 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplementary Figure S1. Experimental design and quality control analysis for Methyl-Seq data. (A) FVB mice were bred to become pregnant (parous, P) and underwent a complete pregnancy (Pr), lactation (L), and Involution (I). Animals were t…
View article: Supplementary Figure Legends from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure Legends from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
All Supplementary Figure legends are included in this document.