Nicola Elvassore
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View article: Functional <scp>CRISPR</scp> ‐ <scp>Cas9</scp> knockout screening of the genetic determinants of human fibroblast migration propensity
Functional <span>CRISPR</span> ‐ <span>Cas9</span> knockout screening of the genetic determinants of human fibroblast migration propensity Open
Directional cell migration plays a central role in a wide range of physiological and pathological conditions, such as embryonic development or tumor metastasis. Steps involved in cell migration include cell polarization, formation of membr…
View article: Early Reprogramming Intermediates Enable Direct Neuronal Conversion via NGN2
Early Reprogramming Intermediates Enable Direct Neuronal Conversion via NGN2 Open
The generation of engineered neurons via Neurogenin-2 (NGN2) overexpression, starting from human induced pluripotent stem cells (hiPSCs), is a powerful tool for modeling neurological diseases. However, using stabilized hiPSCs as a starting…
View article: Early Reprogramming Intermediates Enable Direct Neuronal Conversion via NGN2
Early Reprogramming Intermediates Enable Direct Neuronal Conversion via NGN2 Open
The generation of engineered neurons via Neurogenin-2 (NGN2) overexpression, starting from human induced pluripotent stem cells (hiPSCs), is a powerful tool for modeling neurological diseases. However, using stabilized hiPSCs as a starting…
View article: Tissue-engineered neuromuscular organoids
Tissue-engineered neuromuscular organoids Open
Skeletal muscle development, homeostasis, and function rely on complex interactions among multiple cell types and the extracellular matrix (ECM). Developing in vitro models that recapitulate both intrinsic cellular and extrinsic ECM elemen…
View article: Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction (Adv. Healthcare Mater. 17/2025)
Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction (Adv. Healthcare Mater. 17/2025) Open
View article: Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation
Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation Open
Spina bifida and anencephaly are neural tube defects caused by failure of embryonic neural tube closure. Successful closure requires elongation and apical constriction of neuroepithelial cells. These critical behaviours have not been studi…
View article: Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction
Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction Open
Skeletal muscle (SkM) tissue engineering aims to generate in vitro 3D products that can be implanted in patients to replace or repair damaged muscles. Having a humanized in vitro model able to mimic the interaction between the innervated r…
View article: In situ tailored confining microenvironment for lung cancer spheroids
In situ tailored confining microenvironment for lung cancer spheroids Open
View article: Engineering assembloids to mimic graft-host skeletal muscle interaction
Engineering assembloids to mimic graft-host skeletal muscle interaction Open
Skeletal muscle (SkM) tissue engineering aims to generate in vitro three-dimensional (3D) products that can be implanted in patients to replace or repair damaged muscles. Having a humanized in vitro model able to mimic the interaction betw…
View article: From naïve pluripotency to human neural organoids through a three-dimensional morphogenetic continuum
From naïve pluripotency to human neural organoids through a three-dimensional morphogenetic continuum Open
Summary Human central nervous system (CNS) development involves complex transitions from pluripotency to regionalised neural tissues. The early phases of this process are inaccessible in humans but can potentially be modelled in vitro usin…
View article: Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer Open
View article: Functional CRISPR-Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity
Functional CRISPR-Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity Open
Directional cell migration plays a central role in a wide range of physiological and pathological conditions, such as embryonic development or tumor metastasis. Steps involved in cell migration include cell polarization, formation of membr…
View article: Quantifying mechanical forces during vertebrate morphogenesis
Quantifying mechanical forces during vertebrate morphogenesis Open
View article: Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition
Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition Open
During neural tube (NT) development, the notochord induces an organizer, the floorplate, which secretes Sonic Hedgehog (SHH) to pattern neural progenitors. Conversely, NT organoids (NTOs) from embryonic stem cells (ESCs) spontaneously form…
View article: Functional CRISPR-Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity
Functional CRISPR-Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity Open
Directional cell migration plays a central role in a wide range of physiological and pathological conditions, such as inflammation and cancer. Steps involved in cell migration include cell polarization, formation of membrane protrusions at…
View article: Prenatal VEGF Nano-Delivery Reverses Congenital Diaphragmatic Hernia-Associated Pulmonary Abnormalities
Prenatal VEGF Nano-Delivery Reverses Congenital Diaphragmatic Hernia-Associated Pulmonary Abnormalities Open
Rationale Congenital diaphragmatic hernia (CDH) results in lung hypoplasia. In severe cases, tracheal occlusion (TO) can be offered to promote lung growth. However the benefit is limited, and novel treatments are required to supplement TO.…
View article: Insight and Recommendations for Fragile X-Premutation-Associated Conditions from the Fifth International Conference on FMR1 Premutation
Insight and Recommendations for Fragile X-Premutation-Associated Conditions from the Fifth International Conference on FMR1 Premutation Open
The premutation of the fragile X messenger ribonucleoprotein 1 (FMR1) gene is characterized by an expansion of the CGG trinucleotide repeats (55 to 200 CGGs) in the 5’ untranslated region and increased levels of FMR1 mRNA. Molecular mechan…
View article: Insight and Recommendations for Fragile X Premutation Associated Conditions from the 5th International Conference on <em>FMR1</em> Premutation
Insight and Recommendations for Fragile X Premutation Associated Conditions from the 5th International Conference on <em>FMR1</em> Premutation Open
The premutation of the fragile X messenger ribonucleoprotein 1 (FMR1) gene is characterized by an expansion of the CGG trinucleotide repeats (55 to 200 CGGs) in the 5' untranslated region, and increased levels of FMR1 mRNA. Molecular …
View article: Neural tube organoids self-organise floorplate through BMP-mediated cluster competition
Neural tube organoids self-organise floorplate through BMP-mediated cluster competition Open
The neural tube (NT) has been a hallmark example of embryonic induction and patterning whereby the notochord induces an organiser, the floorplate, that secretes Sonic Hedgehog (SHH) to pattern the surrounding field of neural progenitors. O…
View article: Lung viral infection modelling in a bioengineered whole-organ
Lung viral infection modelling in a bioengineered whole-organ Open
View article: Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures
Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures Open
Three-dimensional hydrogel-based organ-like cultures can be applied to study development, regeneration, and disease in vitro. However, the control of engineered hydrogel composition, mechanical properties and geometrical constraints tends …
View article: Native extracellular matrix promotes human neuromuscular organoid morphogenesis and function
Native extracellular matrix promotes human neuromuscular organoid morphogenesis and function Open
Human neuromuscular organoids (NMOs) derived from induced pluripotent stem cells (hiPSCs) hold a great potential to study (dys)functional human skeletal muscle (SkM) in vitro. The three-dimensional (3D) self-assembly of NMOs leads to the g…
View article: Cellular population dynamics shape the route to human pluripotency
Cellular population dynamics shape the route to human pluripotency Open
Human cellular reprogramming to induced pluripotency is still an inefficient process, which has hindered studying the role of critical intermediate stages. Here we take advantage of high efficiency reprogramming in microfluidics and tempor…
View article: Lung viral infection modelling in a bioengineered whole-organ
Lung viral infection modelling in a bioengineered whole-organ Open
Lung infections are one of the leading causes of death worldwide, and this situation has been exacerbated by the emergence of COVID-19. Pre-clinical modelling of viral infections has relied on cell cultures that lack 3D structure and the c…
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View article: Synchronisation of apical constriction and cell cycle progression is a conserved behaviour of pseudostratified neuroepithelia informed by their tissue geometry
Synchronisation of apical constriction and cell cycle progression is a conserved behaviour of pseudostratified neuroepithelia informed by their tissue geometry Open
View article: 3D ECM-rich environment sustains the identity of naive human iPSCs
3D ECM-rich environment sustains the identity of naive human iPSCs Open
View article: Cellular population dynamics shape the route to human pluripotency
Cellular population dynamics shape the route to human pluripotency Open
Human cellular reprogramming to induced pluripotency is still an inefficient process and this has long hindered the study of the role of critical intermediate stages. We take advantage of high efficiency reprogramming in microfluidics and …
View article: Establishment of a human 3D pancreatic adenocarcinoma model based on a patient-derived extracellular matrix scaffold
Establishment of a human 3D pancreatic adenocarcinoma model based on a patient-derived extracellular matrix scaffold Open