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View article: High-phosphate causes endothelial extracellular matrix calcification by inducing endothelial cell mesenchymal transition and osteoblastic differentiation
High-phosphate causes endothelial extracellular matrix calcification by inducing endothelial cell mesenchymal transition and osteoblastic differentiation Open
The significance of this study is the demonstration that, in chronic kidney disease (CKD), intima is not a passive actor but undergoes deep changes up to osteoblastic-like differentiation and calcification. Considering these new findings, …
View article: Comparative effects of polyvinyl chloride microplastics on the brittle star Ophiactis virens and the amphibian Xenopus laevis
Comparative effects of polyvinyl chloride microplastics on the brittle star Ophiactis virens and the amphibian Xenopus laevis Open
In this study, we investigated the effects of PVC microplastics (PVC-MPs) using two different animal models: the brittle star Ophiactis virens, and the African clawed frog Xenopus laevis. This is the first study using an environmental rele…
View article: Teratogenic and neuro-behavioural toxic effects of bisphenol A (BPA) and B (BPB) on Xenopus laevis development
Teratogenic and neuro-behavioural toxic effects of bisphenol A (BPA) and B (BPB) on Xenopus laevis development Open
Bisphenol A (BPA) is a plastic additive with endocrine disruptive activity, classified in 2017 by EU ECHA as substance of very high concern. A correlation between environmental exposure to BPA and congenital defects has been described in h…
View article: Acid-derived bacterial cellulose nanocrystals as organic filler for the generation of high-oxygen barrier bio-nanocomposite coatings
Acid-derived bacterial cellulose nanocrystals as organic filler for the generation of high-oxygen barrier bio-nanocomposite coatings Open
This study investigates the effect of the hydrolysis process on bacterial cellulose (BC) to obtain bacterial cellulose nanocrystals (BCNCs) used to create high oxygen barrier nanocomposite coatings for food packaging applications.
View article: In Vitro Activity of the Arylaminoartemisinin GC012 against Helicobacter pylori and Its Effects on Biofilm
In Vitro Activity of the Arylaminoartemisinin GC012 against Helicobacter pylori and Its Effects on Biofilm Open
This study evaluated the in vitro activity of the arylaminoartemisinin GC012, readily obtained from dihydroartemisinin (DHA), against clinical strains of Helicobacter pylori (H. pylori) with different antibiotic susceptibilities in the pla…
View article: The Toxicity of Polyester Fibers in Xenopuslaevis
The Toxicity of Polyester Fibers in Xenopuslaevis Open
Microplastics are practically ubiquitous and pose a serious survival challenge for many species. Most of the exposure experiments for determining the toxicological effects of microplastics were performed with a microplastic varying little …
View article: Inner Ear and Muscle Developmental Defects in Smpx-Deficient Zebrafish Embryos
Inner Ear and Muscle Developmental Defects in Smpx-Deficient Zebrafish Embryos Open
The last decade has witnessed the identification of several families affected by hereditary non-syndromic hearing loss (NSHL) caused by mutations in the SMPX gene and the loss of function has been suggested as the underlying mechanism. In …
View article: Myocardial hypoxic stress mediates functional cardiac extracellular vesicle release
Myocardial hypoxic stress mediates functional cardiac extracellular vesicle release Open
Aims Increased shedding of extracellular vesicles (EVs)—small, lipid bilayer-delimited particles with a role in paracrine signalling—has been associated with human pathologies, e.g. atherosclerosis, but whether this is true for cardiac dis…
View article: Lung organoids and microplastic fibers: a new exposure model for emerging contaminants
Lung organoids and microplastic fibers: a new exposure model for emerging contaminants Open
Background Three-dimensional (3D) structured organoids are the most advanced in vitro models for studying human health effects, but they have been applied only once to evaluate the biological effects associated with microplastic exposure. …
View article: Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena
Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena Open
A disintegrin and metalloproteinase 10 (ADAM10) is a synaptic enzyme that has been previously shown to limit amyloid-β1-42 (Aβ1-42) peptide formation in Alzheimer's disease (AD). Furthermore, ADAM10 participates to spine shaping through th…
View article: Enzymatic Hydrolysis in the Green Production of Bacterial Cellulose Nanocrystals
Enzymatic Hydrolysis in the Green Production of Bacterial Cellulose Nanocrystals Open
In this study, we extensively describe experimental models, with correlating experimental conditions, which were used to investigate the enzymatic hydrolysis of bacterial cellulose (BC) to obtain nanocrystals. Cellulase from Trichoderma re…
View article: Comparative toxicity of three differently shaped carbon nanomaterials on<i>Daphnia magna</i>: does a shape effect exist?
Comparative toxicity of three differently shaped carbon nanomaterials on<i>Daphnia magna</i>: does a shape effect exist? Open
The acute toxicity of three differently shaped carbon nanomaterials (CNMs) was studied on Daphnia magna, comparing the induced effects and looking for the toxic mechanisms. We used carbon nano-powder (CNP), with almost spherical primary pa…
View article: Comparative toxicity of three differently shaped carbon nanomaterials on <i>Daphnia magna</i>: does a shape effect exist?
Comparative toxicity of three differently shaped carbon nanomaterials on <i>Daphnia magna</i>: does a shape effect exist? Open
The acute toxicity of three differently shaped carbon nanomaterials (CNMs) was studied on Daphnia magna, comparing the induced effects and looking for the toxic mechanisms. We used carbon nano-powder (CNP), with almost spherical primary pa…
View article: Sol-gel TiO<sub>2</sub>colloidal suspensions and nanostructured thin films: structural and biological assessments
Sol-gel TiO<sub>2</sub>colloidal suspensions and nanostructured thin films: structural and biological assessments Open
The role of substrate topography in phenotype expression of in vitro cultured cells has been widely assessed. However, the production of the nanostructured interface via the deposition of sol-gel synthesized nanoparticles (NPs) has not yet…
View article: Carbon nanopowder acts as a Trojan-horse for benzo(α)pyrene in<i>Danio rerio</i>embryos
Carbon nanopowder acts as a Trojan-horse for benzo(α)pyrene in<i>Danio rerio</i>embryos Open
Carbon-based nanoparticles (CBNs) are largely distributed worldwide due to fossil fuel combustion and their presence in many consumer products. In addition to their proven toxicological effects in several biological models, attention in re…
View article: Adsorption of B(α)P on carbon nanopowder affects accumulation and toxicity in zebrafish (Danio rerio) embryos
Adsorption of B(α)P on carbon nanopowder affects accumulation and toxicity in zebrafish (Danio rerio) embryos Open
The interactions of nanomaterials with contaminants represent great concern for the environment and human health.
View article: Carbon nanopowder acts as a Trojan-horse for benzo(α)pyrene in <i>Danio rerio</i> embryos
Carbon nanopowder acts as a Trojan-horse for benzo(α)pyrene in <i>Danio rerio</i> embryos Open
Carbon-based nanoparticles (CBNs) are largely distributed worldwide due to fossil fuel combustion and their presence in many consumer products. In addition to their proven toxicological effects in several biological models, attention in re…