John N. Greene
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View article: Purpura Fulminans Due to Escherichia coli Septicemia in Relapsed Acute Myeloid Leukemia: An Unusual Case of Protein C Deficiency and Disseminated Intravascular Coagulation
Purpura Fulminans Due to Escherichia coli Septicemia in Relapsed Acute Myeloid Leukemia: An Unusual Case of Protein C Deficiency and Disseminated Intravascular Coagulation Open
Purpura fulminans (PF) is a rare and life-threatening condition characterized by rapid development of cutaneous microvascular thrombosis and skin necrosis, typically associated with disseminated intravascular coagulation (DIC). Here, we pr…
Mycobacterium Avium Complex (MAC) Lung Infection Mimics Lung Cancer Nodules But Improves After Antibiotic Therapy Open
BACKGROUNDInfection with non-tuberculous mycobacterium species commonly can present with lung nodules mimicking lung cancer on routine chest imaging leading to unnecessary invasive procedures.CASE SERIESThe authors report three representat…
Rare Cases of Escherichia coli-Induced Aortitis in Immunocompromised Patients Open
Infectious aortitis is a rare, life-threatening condition, with Escherichia coli being an exceptionally uncommon causative pathogen. This case series highlights 2 instances of E coli-induced aortitis in immunocompromised patients, illustra…
P-1024. Fungal Pneumonia and Severe Neutropenia: Risk Factors for Increased 90 Day Mortality Open
Background Invasive fungal infections (IFI) carry a high mortality risk in hematologic malignancy; the majority being pulmonary infections. Diagnosis is based on consensus definitions of host factors, clinical features and mycologic eviden…
A case series of intertriginous rashes in cancer patients Open
Introduction: Immunocompromised patients, especially those with cancer, face an elevated risk of developing inflamed and painful rashes between the skinfolds. These intertriginous conditions are not always easy to identify. Case Series: We…
Masquerading parasites: A case study on pulmonary echinococcosis mimicking lung cancer and bronchogenic cyst Open
Introduction: Pulmonary echinococcosis, caused by the larval stage of Echinococcus granuloses, presents significant diagnostic challenges, often mimicking more common thoracic pathologies, such as lung cancer and bronchogenic cysts. This r…
Real-world Experience of Posaconazole Therapeutic Drug Monitoring in Oncology Patients: Clinical Implications of Hypoalbuminemia as a Predictor of Subtherapeutic Posaconazole Levels Open
Background Posaconazole maintains broad antifungal activity and is employed for prevention and treatment of invasive fungal infections in oncology patients. Older formulations required therapeutic drug monitoring, and specific plasma drug …
Malignant pleural disease Open
Malignant pleural disease represents a growing healthcare burden. Malignant pleural effusion affects approximately 1 million people globally per year, causes disabling breathlessness and indicates a shortened life expectancy. Timely diagno…
974. Real World Experience of Posaconazole Therapeutic Drug Monitoring in Oncology Patients: Clinical Implications of Hypoalbuminemia as a Predictor of Subtherapeutic Posaconazole Levels Open
Background Posaconazole (POS) is utilized for prophylaxis or treatment of invasive fungal infections (IFI) in patients with malignancies or following stem cell transplant (SCT). Subtherapeutic levels may be associated with breakthrough inf…
2830. Clinical Characteristics, Outcomes and Antimicrobial Resistance of Non-aeruginosa Pseudomonas Infection in Adult Cancer Patients Open
Background Pseudomonas aeruginosa a gram-negative bacteria that is known to cause severe nosocomial infections. Other species of Pseudomonas are considered to be part of the human indigenous microbiota, commonly found in sites such as the …
The epidemiology, mechanisms, diagnosis and treatment of cardiovascular disease in adult patients with HIV. Open
More than 1.2 million people in the United States have Human Immunodeficiency Virus (HIV) infections but 13% of these people are unaware of their HIV infection. Current combination antiretroviral therapy (ART) does not cure HIV infection b…
Safety and Outcomes With Combination Therapy With Sarilumab and Baricitinib for Severe COVID-19 Respiratory Infection in Cancer Patients Open
Objectives This study aims to describe the clinical outcomes of combination therapy with sarilumab and baricitinib for severe novel Coronavirus-19 (COVID-19) infection in cancer patients. With this study, we aim to evaluate the role of exp…
Multidisciplinary approach in diagnosis and treatment of COVID-19-associated mucormycosis: a description of current reports Open
Background We reviewed the epidemiology, risk factors, pathophysiology, and clinical presentations of coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM), then discussed the importance of rapid diagnosis and treatment facilit…
755. <i>Clostridioides difficile</i> Testing and the Use of Laxatives in Immunocompromised Adults Open
Background Clostridioides difficile infection (CDI) rates have plateaued at historical highs in the United States since 2010 and remains a major health problem. While optimal CDI testing remains unclear, current literature recommends testi…
Management of Severe Hidradenitis Suppurativa Open
Hidradenitis suppurativa (HS) is a devastating and disfiguring disease of the skin involving the terminal follicular epithelium within the apocrine-gland-bearing skin. We present an interesting case of a 58-year-old female who presented wi…
Successful Treatment of Community-Acquired Methicillin-Resistant Staphylococcus Aureus Necrotizing Pneumonia in the Setting of Chronic Graft-Versus-Host Disease Open
Necrotizing pneumonia (NP) is a rare complication of community-acquired pneumonia that results in tissue necrosis and permanent destruction of the lung parenchyma. This study presents a case of a 21-year old male patient with T-cell acute …
COVID-19 in Immunocompromised Cancer Patients: A Case Series and Review of the Literature Open
The global pandemic of the novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has presented newfound challenges to the oncology community regarding management of disease progr…
Preventing the Spread: A Comprehensive Cancer Center’s Journey to Prevent the Spread of Coronavirus Disease (Covid-19) During the 2020 Pandemic Open
Background: On March 11, 2020, the World Health Organization (WHO) declared Coronavirus Disease (COVID-19) a pandemic. Hospitals around the world began to implement infection prevention and control (IPC) measures to stop further spread and…
1301. Breakthrough Invasive Fungal Infections based on CYP2C19 Levels in Patients Who were on Voriconazole as Primary Antifungal Prophylaxis in Acute Myeloid Leukemia (AML) undergoing Induction Chemotherapy Open
Background Voriconazole (Vori) is often used for prophylactic anti-fungal therapy in induction chemotherapy for Acute Myeloid Leukemia (AML) patients due to predictable absorption and an extended spectrum antifungal activity. Vori is metab…
282. Epidemiological Evaluation of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) and Methicillin-Susceptible <i>Staphylococcus aureus</i> (MSSA) Bacteremia: A Comprehensive Cancer Center’s 10-Year Experience Open
Background Coagulase-positive Staphylococcus aureus bacteremia among cancer patients carries significant morbidity and mortality. This study aims to compare the risk factors and clinical outcomes among cancer patients diagnosed with bloods…
742. Breakthrough Invasive Fungal Infections with Isavuconazonium Sulfate versus Voriconazole as Primary Antifungal Prophylaxis in Patients with Acute Myeloid Leukemia (AML) who Received Induction Chemotherapy Open
Background Fungal infections in patients with hematologic malignancies are associated with high mortality. Primary antifungal prophylaxis has been shown to be a more effective strategy than treating a documented infection. This retrospecti…