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View article: Research progress in the prevention and treatment of radiation-induced heart disease
Research progress in the prevention and treatment of radiation-induced heart disease Open
Radiotherapy (RT) is a cornerstone treatment for thoracic malignancies, but is associated with an increased risk of radiation-induced heart disease (RIHD), a major cause of long-term morbidity and mortality in cancer survivors. Ionizing ra…
View article: The comprehensive landscape of <i>TTMV::RARA</i> fusion-driven acute myeloid leukemia: from viral integration mechanisms to clinical outcomes
The comprehensive landscape of <i>TTMV::RARA</i> fusion-driven acute myeloid leukemia: from viral integration mechanisms to clinical outcomes Open
Acute myeloid leukemia (AML) with TTMV::RARA fusion represents a novel subtype driven by torque teno mini virus (TTMV) integration into retinoic acid receptor alpha (RARA) locus, while current understanding of its molecular features and cl…
View article: miR-191-5p attenuates TNF-α-induced inflammation in nucleus pulposus cells via targeting EGR1
miR-191-5p attenuates TNF-α-induced inflammation in nucleus pulposus cells via targeting EGR1 Open
miR-191-5p enhanced cell viability and migration while concurrently suppressing ECM degradation, apoptosis and inflammatory responses via negative regulation of EGR1, which in turn inhibited the progression of IVDD.
View article: Non‑targeted metabolomics reveals diagnostic biomarker in the plasma of patients with lung cancer
Non‑targeted metabolomics reveals diagnostic biomarker in the plasma of patients with lung cancer Open
Lung cancers are malignant tumors with high incidence and mortality rates and a 5-year survival rate that depends on the stage at the time of diagnosis. Screening methods for lung cancer are becoming increasingly diverse, but existing appr…
View article: M1 macrophage-targeted glucose-functionalized nanoparticles for berberine delivery and inflammatory microenvironment remodeling in osteoarthritis therapy
M1 macrophage-targeted glucose-functionalized nanoparticles for berberine delivery and inflammatory microenvironment remodeling in osteoarthritis therapy Open
The inflammatory microenvironment mediated by synovial macrophages, particularly the pro-inflammatory M1 subtype, plays a central role in OA progression and represents a critical therapeutic target. However, delivery strategies that enable…
View article: Count Counts: Motivating Exploration in LLM Reasoning with Count-based Intrinsic Rewards
Count Counts: Motivating Exploration in LLM Reasoning with Count-based Intrinsic Rewards Open
Reinforcement Learning (RL) has become a compelling way to strengthen the multi step reasoning ability of Large Language Models (LLMs). However, prevalent RL paradigms still lean on sparse outcome-based rewards and limited exploration, whi…
View article: A bibliometric analysis and systematic review of drug repurposing against drug-resistant ESKAPE pathogens: a particular focus on Pseudomonas aeruginosa
A bibliometric analysis and systematic review of drug repurposing against drug-resistant ESKAPE pathogens: a particular focus on Pseudomonas aeruginosa Open
Purpose Drug-resistant ESKAPE pathogens represent a major global health challenge. This study included a comprehensive bibliometric analysis and systematic review to evaluate drug repurposing efforts against these pathogens, with a particu…
View article: ICECleSHZ29: Novel Integrative and Conjugative Element (ICE)-Carrying Tigecycline Resistance Gene tet(X6) in Chryseobacterium lecithinasegens
ICECleSHZ29: Novel Integrative and Conjugative Element (ICE)-Carrying Tigecycline Resistance Gene tet(X6) in Chryseobacterium lecithinasegens Open
Background/Objectives: The global dissemination of tet(X) variants critically threatens tigecycline efficacy as a last-resort antibiotic. The aim of this study was to characterize a tet(X6)-carrying integrative and conjugative element (ICE…
View article: Human Pluripotent Stem Cell-Derived Alveolar Organoids for Gene-editing and Lung Adenocarcinomas Modeling
Human Pluripotent Stem Cell-Derived Alveolar Organoids for Gene-editing and Lung Adenocarcinomas Modeling Open
Human pluripotent stem cell (hPSC)-derived alveolar organoids have emerged as valuable tools for studying lung development, modeling pulmonary diseases, and drug discovery, though their application has been hindered by laborious differenti…
View article: Bioengineered milk-derived extracellular vesicles implementing high drug loading and membrane integrity for efficient oral drug delivery
Bioengineered milk-derived extracellular vesicles implementing high drug loading and membrane integrity for efficient oral drug delivery Open
Milk-derived extracellular vesicles (EVs) are promising for oral drug delivery, yet different loading methods exhibit distinct impacts on drug encapsulation and membrane integrity. This study demonstrated that sonication method achieved hi…
View article: Development and validation of a multimodal automatic interictal epileptiform discharge detection model: a prospective multi-center study
Development and validation of a multimodal automatic interictal epileptiform discharge detection model: a prospective multi-center study Open
View article: Enhanced homing and efficacy of HER2-CAR T cells via CXCR5/CCR6 co-expression for HER2-positive NSCLC
Enhanced homing and efficacy of HER2-CAR T cells via CXCR5/CCR6 co-expression for HER2-positive NSCLC Open
Background Chimeric antigen receptor T-cell (CAR T) therapy development represents a promising therapeutic strategy for HER2-positive non-small cell lung cancer (NSCLC), a subtype accounting for 1–5% of NSCLC cases. However, the clinical e…
View article: MRI-based texture analysis for the evaluation of the response to neoadjuvant chemoimmunotherapy in locally advanced head and neck squamous cell carcinoma
MRI-based texture analysis for the evaluation of the response to neoadjuvant chemoimmunotherapy in locally advanced head and neck squamous cell carcinoma Open
Not applicable.
View article: [Recent advances in the diagnosis and management of Ph(+) acute lymphoblastic leukemia with multilineage involvement].
[Recent advances in the diagnosis and management of Ph(+) acute lymphoblastic leukemia with multilineage involvement]. Open
The evolving stratified treatment approach based on molecular genetic alterations and minimal residual disease (MRD) monitoring has established a strong foundation for clinically managing Philadelphia chromosome-positive acute lymphoblasti…
View article: Value of integrated PET-IVIM MRI in predicting Ki-67 expression in newly diagnosed prostate cancer
Value of integrated PET-IVIM MRI in predicting Ki-67 expression in newly diagnosed prostate cancer Open
Accurate assessment of Ki-67 expression in patients with prostate cancer (PC) is paramount. Therefore, this study aimed to assess the value of integrated Gallium-68( 68 Ga)-prostate-Specific membrane antigen-11 (PSMA) Positron Emission Tom…
View article: Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1
Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 Open
The identification of the LINC00339-PARP1-CDC42 regulatory axis elucidates a novel molecular mechanism contributing to osteoporosis pathogenesis. This discovery not only advances our understanding of epigenetic regulation in bone remodelin…
View article: [Association between DNA methylation clock and obesity-related indicators: A longitudinal twin study].
[Association between DNA methylation clock and obesity-related indicators: A longitudinal twin study]. Open
Obesity indicators correlate with DNA methylation clock acceleration metrics. Baseline obesity may influence changes in certain DNA methylation clock indicators over time, suggesting that obesity could exert long-term health effects by acc…
View article: The clinical features, muscle pathology, and role of autophagy in anti-Ku-positive patients
The clinical features, muscle pathology, and role of autophagy in anti-Ku-positive patients Open
Aims This study aimed to examine the clinical and muscle histological characteristics of anti-Ku-positive patients. A preliminary investigation into the involvement of autophagy was conducted as well. Methods Clinical characteristics, labo…
View article: Pangu Ultra MoE: How to Train Your Big MoE on Ascend NPUs
Pangu Ultra MoE: How to Train Your Big MoE on Ascend NPUs Open
Sparse large language models (LLMs) with Mixture of Experts (MoE) and close to a trillion parameters are dominating the realm of most capable language models. However, the massive model scale poses significant challenges for the underlying…
View article: USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2α-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells
USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2α-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells Open
Ubiquitin-specific peptidase 18 (USP18) is a specific interferon-stimulated gene 15 demodifying enzyme that plays an important role in apoptosis. In this study, we investigated the role of USP18 in apoptosis in hepatocellular carcinoma cel…
View article: Destroy and Repair Using Hyper Graphs for Routing
Destroy and Repair Using Hyper Graphs for Routing Open
Recent advancements in Neural Combinatorial Optimization (NCO) have shown promise in solving routing problems like the Traveling Salesman Problem (TSP) and Capacitated Vehicle Routing Problem (CVRP) without handcrafted designs. Research in…
View article: An EEG dataset for interictal epileptiform discharge with spatial distribution information
An EEG dataset for interictal epileptiform discharge with spatial distribution information Open
Interictal epileptiform discharge (IED) and its spatial distribution are critical for the diagnosis, classification, and treatment of epilepsy. Existing publicly available datasets suffer from limitations such as insufficient data amount a…
View article: SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci
SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci Open
View article: Mechanistic insights into 5-aminolevulinic acid photodynamic therapy for acne vulgaris: targeting lipogenesis via the OLR1-Wnt/β-catenin pathway
Mechanistic insights into 5-aminolevulinic acid photodynamic therapy for acne vulgaris: targeting lipogenesis via the OLR1-Wnt/β-catenin pathway Open
View article: Dual-BEV Nav: Dual-layer BEV-based Heuristic Path Planning for Robotic Navigation in Unstructured Outdoor Environments
Dual-BEV Nav: Dual-layer BEV-based Heuristic Path Planning for Robotic Navigation in Unstructured Outdoor Environments Open
Path planning with strong environmental adaptability plays a crucial role in robotic navigation in unstructured outdoor environments, especially in the case of low-quality location and map information. The path planning ability of a robot …
View article: A Domain Adaptation Framework for Speech Recognition Systems with Only Synthetic data
A Domain Adaptation Framework for Speech Recognition Systems with Only Synthetic data Open
We introduce DAS (Domain Adaptation with Synthetic data), a novel domain adaptation framework for pre-trained ASR model, designed to efficiently adapt to various language-defined domains without requiring any real data. In particular, DAS …
View article: Case Report: Novel ADA2 variants cause atypical adenosine deaminase 2 deficiency
Case Report: Novel ADA2 variants cause atypical adenosine deaminase 2 deficiency Open
Case presentation A girl aged 2 years and 5 months presented to the hospital with chief complaints of intermittent fever and weakness of the left limb for more than 1 month. The child had transient urticaria appearing on her face for 5 day…
View article: Hydroxysafflor Yellow a Promotes Zebrafish Cardiac Regeneration
Hydroxysafflor Yellow a Promotes Zebrafish Cardiac Regeneration Open
View article: Spatial Distribution of Ice and Snow Tourism Resource Sites in Xinjiang Region Based on Logarithmic Gaussian Cox Model and Its Influencing Factor Analysis
Spatial Distribution of Ice and Snow Tourism Resource Sites in Xinjiang Region Based on Logarithmic Gaussian Cox Model and Its Influencing Factor Analysis Open
Xinjiang is rich in snow and ice tourism resources, and exploring the spatial distribution pattern of snow and ice tourism resource points in the region, and the influence mechanism behind it can provide decision support for the region to …
View article: Ginsenoside Rh2 Ameliorates Pulmonary Fibrosis Via Hsp70-P53-Dependent Autophagic Flux Regulation and Senescence Arrest
Ginsenoside Rh2 Ameliorates Pulmonary Fibrosis Via Hsp70-P53-Dependent Autophagic Flux Regulation and Senescence Arrest Open