Nazanin Zounemat Kermani
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View article: Proteomic and Transcriptomic Signatures of Poor Asthma Symptom Control in the U‐BIOPRED Cohort
Proteomic and Transcriptomic Signatures of Poor Asthma Symptom Control in the U‐BIOPRED Cohort Open
Background Controlling asthma symptoms remains challenging. Understanding its molecular mechanisms may provide new insights into asthma pathophysiology. We explored the associations between the transcriptome and proteome in blood and sputu…
View article: Multidrug-resistant <i>Haemophilus influenzae</i> cluster of severe asthma from sputum bacteriome-resistome
Multidrug-resistant <i>Haemophilus influenzae</i> cluster of severe asthma from sputum bacteriome-resistome Open
Background Severe asthma encompasses heterogeneous inflammatory phenotypes and airway bacteriome diversity but the state of its airway resistome remains understudied. We therefore evaluated the link between the airway microbiome and the an…
View article: Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History
Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History Open
Background Early identification of children at risk of asthma attacks is important for optimizing treatment strategies. We aimed to integrate salivary microbiome and serum inflammatory mediator profiles with asthma attacks history to devel…
View article: Exploring geographic differences in IgE response through network and manifold analyses
Exploring geographic differences in IgE response through network and manifold analyses Open
Patterns of c-sIgE response reflect geographic location and study design. However, despite geographic differences in c-sIgE networks, there is a remarkably consistent shift between networks of subjects with nonsevere and severe asthma.
View article: An AI-driven framework for the prediction of personalised health response to air pollution
An AI-driven framework for the prediction of personalised health response to air pollution Open
Air pollution poses a significant threat to public health, causing or exacerbating many respiratory and cardiovascular diseases. In addition, climate change is bringing about more extreme weather events such as wildfires and heatwaves, whi…
View article: Female sex hormones and the oral contraceptive pill modulate asthma severity through GLUT-1
Female sex hormones and the oral contraceptive pill modulate asthma severity through GLUT-1 Open
Females are disproportionately affected by asthma. An increased understanding of how female sex hormones influence key pathophysiological processes that underpin asthma may identify new, more effective asthma therapies, particularly for fe…
View article: Distinct single-cell transcriptional profile in CD4+ T-lymphocytes among obese children with asthma
Distinct single-cell transcriptional profile in CD4+ T-lymphocytes among obese children with asthma Open
This study identified unique contributors to asthma in children with obesity and found novel pathways. Increased expression of IL-7R, IL-32, PARP-1, FKBP5 gene, IL-6, and Rho transcriptional signaling were observed in obese individuals wit…
View article: Neutrophilic inflammation in sputum or blood does not define a clinically distinct asthma phenotype in ATLANTIS
Neutrophilic inflammation in sputum or blood does not define a clinically distinct asthma phenotype in ATLANTIS Open
Introduction Neutrophilic asthma has been suggested to be a clinically distinct phenotype characterised by more severe airflow obstruction and higher exacerbation risk. However, this has only been assessed in few and smaller studies, using…
View article: Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics
Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics Open
Background Lung quantitative computed tomography (qCT) severe asthma clusters have been reported, but their replication and underlying disease mechanisms are unknown. We identified and replicated qCT clusters of severe asthma in two indepe…
View article: A severe asthma phenotype of excessive airway <i>Haemophilus influenzae</i> relative abundance associated with sputum neutrophilia
A severe asthma phenotype of excessive airway <i>Haemophilus influenzae</i> relative abundance associated with sputum neutrophilia Open
Background Severe asthma (SA) encompasses several clinical phenotypes with a heterogeneous airway microbiome. We determined the phenotypes associated with a low α‐diversity microbiome. Methods Metagenomic sequencing was performed on sputum…
View article: Host–microbial interactions differ with age of asthma onset
Host–microbial interactions differ with age of asthma onset Open
The host immune response to pathogens differs between early- and late-onset asthma https://bit.ly/3xSa4Fe
View article: Endotypes of severe neutrophilic and eosinophilic asthma from multi‐omics integration of U‐BIOPRED sputum samples
Endotypes of severe neutrophilic and eosinophilic asthma from multi‐omics integration of U‐BIOPRED sputum samples Open
Background Clustering approaches using single omics platforms are increasingly used to characterise molecular phenotypes of eosinophilic and neutrophilic asthma. Effective integration of multi‐omics platforms should lead towards greater re…
View article: IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status
IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status Open
IL-33 response in Th2 cells is specific to asthma and represents a high risk haplotype, highlighting its role in airway wall cells. Yet, its detection is challenging in bulk asthma transcriptomes due to the scarcity of effector Th2 cells. …
View article: Discovery and Validation of a Volatile Signature of Eosinophilic Airway Inflammation in Asthma
Discovery and Validation of a Volatile Signature of Eosinophilic Airway Inflammation in Asthma Open
Rationale: Volatile organic compounds (VOCs) in asthmatic breath may be associated with sputum eosinophilia. We developed a volatile biomarker signature to predict sputum eosinophilia in asthma. Methods: VOCs emitted into the space above s…
View article: Comparison of Asthma Phenotypes in Severe Asthma Cohorts (SARP, U-BIOPRED, ProAR and COREA) From 4 Continents
Comparison of Asthma Phenotypes in Severe Asthma Cohorts (SARP, U-BIOPRED, ProAR and COREA) From 4 Continents Open
PurposeAsthma is a clinical syndrome with various underlying pathomechanisms and clinical phenotypes. Genetic, ethnic, and geographic factors may influence the differences in clinical presentation, severity, and prognosis. We compared the …
View article: Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputum
Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputum Open
U-BIOPRED has received funding from the Innovative Medicines Initiative (IMI) Joint Undertaking under grant agreement no. 115010, resources of which are composed of financial contributions from the European Union's Seventh Framework Progra…
View article: Survivorship Data in Prostate Cancer: Where Are We and Where Do We Need To Be?
Survivorship Data in Prostate Cancer: Where Are We and Where Do We Need To Be? Open
As there are more prostate cancer survivors than ever before, research into cancer survivorship is crucial. We highlight the importance of such research and provide recommendations on how to carry it out. The first step should be establish…
View article: Consensus clustering with missing labels (ccml): a consensus clustering tool for multi-omics integrative prediction in cohorts with unequal sample coverage
Consensus clustering with missing labels (ccml): a consensus clustering tool for multi-omics integrative prediction in cohorts with unequal sample coverage Open
Multi-omics data integration is a complex and challenging task in biomedical research. Consensus clustering, also known as meta-clustering or cluster ensembles, has become an increasingly popular downstream tool for phenotyping and endotyp…
View article: Gene signatures in U-BIOPRED severe asthma for molecular phenotyping and precision medicine: time for clinical use
Gene signatures in U-BIOPRED severe asthma for molecular phenotyping and precision medicine: time for clinical use Open
Phenotyping on the basis of clinical treatable traits is not sufficient for understanding of mechanisms driving the disease in severe asthma. It is time to consider whether certain patients with severe asthma, such as those non-responsive …
View article: Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids Open
Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthm…
View article: Phenotyping asthma with airflow obstruction in middle-aged and older adults: a CADSET clinical research collaboration
Phenotyping asthma with airflow obstruction in middle-aged and older adults: a CADSET clinical research collaboration Open
Background The prevalence and clinical profile of asthma with airflow obstruction (AO) remain uncertain. We aimed to phenotype AO in population- and clinic-based cohorts. Methods This cross-sectional multicohort study included adults ≥50 y…
View article: Clinical Characterization of Patients Diagnosed with Prostate Cancer and Undergoing Conservative Management: A PIONEER Analysis Based on Big Data
Clinical Characterization of Patients Diagnosed with Prostate Cancer and Undergoing Conservative Management: A PIONEER Analysis Based on Big Data Open
Up to 25% of men with prostate cancer (PCa) managed conservatively experienced hospitalization and emergency department visits within the 1st year after diagnosis; 6% experienced PCa-related symptoms. The probability of receiving therapies…
View article: <i>Haemophilus influenzae</i> and <i>Moraxella catarrhalis</i> in sputum of severe asthma with inflammasome and neutrophil activation
<i>Haemophilus influenzae</i> and <i>Moraxella catarrhalis</i> in sputum of severe asthma with inflammasome and neutrophil activation Open
Background Because of altered airway microbiome in asthma, we analysed the bacterial species in sputum of patients with severe asthma. Methods Whole genome sequencing was performed on induced sputum from non‐smoking (SAn) and current or ex…
View article: Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk
Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk Open
Rationale: Children with preschool wheezing or school-age asthma are reported to have airway microbial imbalances. Objectives: To identify clusters in children with asthma or wheezing using oropharyngeal microbiota profiles. Methods: Oroph…