Naren L. Banik
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View article: Crosstalk between autophagy and apoptosis in initiating antitumor immune responses in human lymphoma cells
Crosstalk between autophagy and apoptosis in initiating antitumor immune responses in human lymphoma cells Open
Aim: Despite advances in lymphoma treatment, resistance to conventional therapies and insufficient immune-mediated tumor clearance remain major challenges. This study investigates the dual antitumor mechanisms of the mushroom-derived trite…
View article: Using a Natural Triterpenoid to Unlock the Antitumor Effects of Autophagy in B-Cell Lymphoma
Using a Natural Triterpenoid to Unlock the Antitumor Effects of Autophagy in B-Cell Lymphoma Open
Background and Objective: Diffuse large B-cell lymphoma (DLBCL), a subtype of non-Hodgkin’s lymphoma, is the most common lymphoid malignancy in the Western world. Treatment of DLBCL has been greatly improved in recent years with the additi…
View article: Dysregulation of Metabolic Peptides Precedes Hyperinsulinemia and Inflammation Following Exposure to Rotenone in Rats
Dysregulation of Metabolic Peptides Precedes Hyperinsulinemia and Inflammation Following Exposure to Rotenone in Rats Open
Rotenone, a naturally occurring compound derived from the roots of tropical plants, is used as a broad-spectrum insecticide, piscicide, and pesticide. It is a classical, high-affinity mitochondrial complex I inhibitor that causes not only …
View article: Disruption of Neuromuscular Junction Following Spinal Cord Injury and Motor Neuron Diseases
Disruption of Neuromuscular Junction Following Spinal Cord Injury and Motor Neuron Diseases Open
The neuromuscular junction (NMJ) is a crucial structure that connects the cholinergic motor neurons to the muscle fibers and allows for muscle contraction and movement. Despite the interruption of the supraspinal pathways that occurs in sp…
View article: Premarin Reduces Neurodegeneration and Promotes Improvement of Function in an Animal Model of Spinal Cord Injury
Premarin Reduces Neurodegeneration and Promotes Improvement of Function in an Animal Model of Spinal Cord Injury Open
Spinal cord injury (SCI) causes significant mortality and morbidity. Currently, no FDA-approved pharmacotherapy is available for treating SCI. Previously, low doses of estrogen (17β-estradiol, E2) were shown to improve the post-injury outc…
View article: Calpain activation and progression of inflammatory cycles in Parkinson’s disease
Calpain activation and progression of inflammatory cycles in Parkinson’s disease Open
Parkinson’s disease (PD) is a progressive, neurodegenerative condition of the central nervous system (CNS) affecting 6.3 million people worldwide with no curative treatments. Current therapies aim to mitigate PD’s effects and offer symptom…
View article: Implications of enolase in the RANKL-mediated osteoclast activity following spinal cord injury
Implications of enolase in the RANKL-mediated osteoclast activity following spinal cord injury Open
Spinal Cord Injury (SCI) is a debilitating condition characterized by damage to the spinal cord, resulting in loss of function, mobility, and sensation. Although increasingly prevalent in the US, no FDA-approved therapy exists due to the u…
View article: Neuroinflammatory responses of microglia in central nervous system trauma
Neuroinflammatory responses of microglia in central nervous system trauma Open
Although relatively few in number compared to astrocytes and neurons, microglia demonstrate multiple, varied neuroimmunological functions in the central nervous system during normal and pathological states. After injury to the brain or spi…
View article: Nanoparticle-Based Estrogen Delivery to Spinal Cord Injury Site Reduces Local Parenchymal Destruction and Improves Functional Recovery
Nanoparticle-Based Estrogen Delivery to Spinal Cord Injury Site Reduces Local Parenchymal Destruction and Improves Functional Recovery Open
Spinal cord injury (SCI) patients sustain significant functional impairments; this is causally related to restricted neuronal regeneration after injury. The ensuing reactive gliosis, inflammatory cascade, and glial scar formation impede ax…
View article: Marion Edmonds Smith (1926–2017)
Marion Edmonds Smith (1926–2017) Open
Marion Edmonds Smith (picture courtesy of Dr. Kendric Smith). Marion Edmonds Smith, Professor of Neurology (Research) at Stanford University, an internationally known pioneer in myelin neurochemistry, died on March 22, 2017 at the age of 9…
View article: New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection
New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection Open
Neurodegeneration is a complex process that leads to irreversible neuronal damage and death in spinal cord injury (SCI) and various neurodegenerative diseases, which are serious, debilitating conditions. Despite exhaustive research, the ca…
View article: Neuron specific enolase is a potential target for regulating neuronal cell survival and death: implications in neurodegeneration and regeneration
Neuron specific enolase is a potential target for regulating neuronal cell survival and death: implications in neurodegeneration and regeneration Open
OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and schol…
View article: Calpain inhibition as a possible new therapeutic target in multiple sclerosis
Calpain inhibition as a possible new therapeutic target in multiple sclerosis Open
Multiple sclerosis (MS), the most common chronic autoimmune inflammatory disease of the central nervous system (CNS), is characterized by demyelination and neurodegeneration. In particular, neurodegeneration is a major factor in disease pr…
View article: RBIO-03. IMPROVING GEMCITABINE-MEDIATED RADIO-SENSITIZATION USING MOLECULARLY TARGETED MENINGIOMA THERAPY
RBIO-03. IMPROVING GEMCITABINE-MEDIATED RADIO-SENSITIZATION USING MOLECULARLY TARGETED MENINGIOMA THERAPY Open
Of the many treatment options, gemcitabine has been currently used clinically to a variety of solid tumors types both as a chemotherapeutic agent and as a radiation sensitizer. However, it has been speculated that the gemcitabine plus rela…
View article: EXTH-39. PRECLINICAL TESTING OF DIETARY HISTONE DEACETYLASE INHIBITORS ON FRESH FIG-ROS1 POSITIVE HUMAN GLIOBLASTOMA TISSUE IN EX-VIVO MODELS
EXTH-39. PRECLINICAL TESTING OF DIETARY HISTONE DEACETYLASE INHIBITORS ON FRESH FIG-ROS1 POSITIVE HUMAN GLIOBLASTOMA TISSUE IN EX-VIVO MODELS Open
Experimental evidence has shown the primary reason for treatment failure in glioblastoma (GBM) is signal redundancy due to co-activation of several functionally linked receptor tyrosine kinases (RTKs), oncogenic c-ros oncogene1 (ROS1: RTK …
View article: IMST-17. PHENOTYPE MODULATION OF TUMOR ASSOCIATED MICROGLIA ENHANCES PEDIATRIC MEDULLOBLASTOMA CELL DEATH IN VITRO
IMST-17. PHENOTYPE MODULATION OF TUMOR ASSOCIATED MICROGLIA ENHANCES PEDIATRIC MEDULLOBLASTOMA CELL DEATH IN VITRO Open
Little is known about the interactions of the CNS immune system microglia with pediatric medulloblastoma cells. Emerging evidence suggests that malignant tumors specifically modify tumor associated microglia (TAM) into an inactive M2-pheno…